SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gs6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN
(Zika
virus) 		4 / 4 ILE A 218
MET A  63
VAL A 162
GLY A 199
 None
 1.19A 1e06B-5gs6A:
undetectable		 1e06B-5gs6A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN
(Zika
virus) 		3 / 3 SER A 239
GLU A 238
GLU A 237
 None
 0.63A 1eqbD-5gs6A:
undetectable		 1eqbD-5gs6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN
(Zika
virus) 		3 / 3 SER A 239
GLU A 238
GLU A 237
 None
 0.63A 1eqbB-5gs6A:
undetectable		 1eqbB-5gs6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN
(Zika
virus) 		3 / 3 ASN A 131
TRP A  50
GLN A  85
 None
 1.21A 1xoqA-5gs6A:
undetectable		 1xoqA-5gs6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN
(Zika
virus) 		5 / 12 LEU A 321
PHE A 323
ILE A 243
PRO A 244
LEU A 217
 None
 1.09A 2w3bB-5gs6A:
undetectable		 2w3bB-5gs6A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN
(Zika
virus) 		3 / 3 SER A   9
GLU A 205
ASP A 208
 None
None
NAG  A 601 ( 4.9A)
 0.77A 2zulA-5gs6A:
undetectable		 2zulA-5gs6A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN
(Zika
virus) 		3 / 3 SER A   9
GLU A 205
ASP A 208
 None
None
NAG  A 601 ( 4.9A)
 0.72A 3dmhA-5gs6A:
undetectable		 3dmhA-5gs6A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN
(Zika
virus) 		5 / 12 LEU A 321
PHE A 323
ILE A 243
PRO A 244
LEU A 217
 None
 1.06A 4kfjB-5gs6A:
undetectable		 4kfjB-5gs6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN
(Zika
virus) 		5 / 12 LEU A 321
PHE A 323
ILE A 243
PRO A 244
LEU A 217
 None
 1.08A 4m6kA-5gs6A:
undetectable		 4m6kA-5gs6A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN
(Zika
virus) 		4 / 4 LEU A 321
ARG A 324
ILE A 275
PHE A 323
 None
 1.14A 5kirB-5gs6A:
undetectable		 5kirB-5gs6A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN
(Zika
virus) 		5 / 10 LEU A  79
GLU A 110
GLY A 114
LEU A  42
ARG A  41
 None
 1.19A 5o96E-5gs6A:
undetectable
5o96F-5gs6A:
undetectable		 5o96E-5gs6A:
22.50
5o96F-5gs6A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN
(Zika
virus) 		5 / 12 ASP A 180
VAL A 171
MET A  67
ALA A  27
VAL A  71
 None
 1.18A 5tudD-5gs6A:
undetectable		 5tudD-5gs6A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN
(Zika
virus) 		4 / 6 GLU A 205
ARG A 211
LYS A 213
PRO A 319
 None
NAG  A 601 (-3.4A)
None
None
 1.18A 6fgdA-5gs6A:
undetectable		 6fgdA-5gs6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN
(Zika
virus) 		4 / 6 GLU A 205
ARG A 257
LYS A 213
PHE A 277
 None
 0.91A 6fgdA-5gs6A:
undetectable		 6fgdA-5gs6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 5gs6 NS1 OF ZIKA VIRUS
FROM 2015 BRAZIL
STRAIN
(Zika
virus) 		4 / 6 GLU A 205
LYS A 213
PHE A 277
PRO A 319
 None
 1.10A 6fgdA-5gs6A:
undetectable		 6fgdA-5gs6A:
22.25