SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gs7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		4 / 7 HIS A  48
PHE A  37
TYR A  64
ILE A  30
 None
 1.46A 1tdnA-5gs7A:
undetectable		 1tdnA-5gs7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		5 / 11 LEU A 279
THR A   6
ILE A  68
LEU A 178
VAL A 165
 None
 1.41A 2n27A-5gs7A:
undetectable		 2n27A-5gs7A:
17.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		3 / 3 ASN A  79
ASN A 170
ARG A 223
 None
 0.15A 2rlcA-5gs7A:
43.4		 2rlcA-5gs7A:
43.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		5 / 9 SER A 234
ILE A 250
ALA A 227
GLY A 211
LEU A 214
 None
 1.20A 2v0mB-5gs7A:
undetectable		 2v0mB-5gs7A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		4 / 5 ASN A  79
LEU A 138
LEU A 135
ASN A 126
 None
 1.25A 4n09C-5gs7A:
undetectable		 4n09C-5gs7A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		3 / 3 LYS A 281
ASN A  69
ASP A  11
 None
 0.76A 4o1eA-5gs7A:
undetectable		 4o1eA-5gs7A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		5 / 12 ASN A 170
ALA A  76
GLY A  77
GLY A  74
PHE A  14
 None
 1.25A 4obwA-5gs7A:
undetectable		 4obwA-5gs7A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		4 / 6 THR A  31
ASP A  60
TYR A  64
LEU A  63
 None
 0.82A 4wozA-5gs7A:
undetectable
4wozB-5gs7A:
undetectable		 4wozA-5gs7A:
21.86
4wozB-5gs7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		4 / 5 ASP A  60
TYR A  64
LEU A  63
THR A  31
 None
 0.89A 4wozF-5gs7A:
undetectable
4wozH-5gs7A:
undetectable		 4wozF-5gs7A:
21.86
4wozH-5gs7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		5 / 12 LEU A 142
ILE A 149
GLY A 166
LEU A  73
VAL A 112
 None
 0.71A 5twjA-5gs7A:
undetectable		 5twjA-5gs7A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		5 / 10 LEU A 142
ILE A 149
GLY A 166
LEU A  73
VAL A 112
 None
 0.73A 5twjB-5gs7A:
undetectable		 5twjB-5gs7A:
17.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		7 / 10 TYR A  24
ILE A  58
LEU A  63
ASN A  79
PHE A  99
LEU A 135
LEU A 138
 None
 1.06A 5y7pB-5gs7A:
48.7		 5y7pB-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		4 / 8 TYR A  24
PHE A  99
LEU A 135
LEU A 138
 None
 0.49A 5y7pC-5gs7A:
49.0		 5y7pC-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		6 / 10 ILE A  58
LEU A  63
ASN A  79
PHE A  99
LEU A 135
LEU A 138
 None
 1.02A 5y7pD-5gs7A:
48.9		 5y7pD-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		6 / 10 TYR A  24
ILE A  58
LEU A  63
ASN A  79
LEU A 135
LEU A 138
 None
 1.10A 5y7pD-5gs7A:
48.9		 5y7pD-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		5 / 8 TYR A  24
ASN A  79
PHE A  99
LEU A 135
LEU A 138
 None
 0.82A 5y7pE-5gs7A:
49.1		 5y7pE-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		4 / 8 TYR A  24
ILE A  58
PHE A  99
LEU A 135
 None
 0.84A 5y7pE-5gs7A:
49.1		 5y7pE-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		5 / 8 TYR A  24
PHE A  99
LEU A 133
LEU A 135
LEU A 138
 None
 0.44A 5y7pE-5gs7A:
49.1		 5y7pE-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		6 / 10 ASN A  79
PHE A  99
LEU A 133
LEU A 135
LEU A 138
GLU A 269
 None
 0.69A 5y7pG-5gs7A:
48.6		 5y7pG-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		6 / 10 ILE A  58
ASN A  79
PHE A  99
LEU A 135
LEU A 138
GLU A 269
 None
 1.05A 5y7pG-5gs7A:
48.6		 5y7pG-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		6 / 10 TYR A  24
ILE A  58
ASN A  79
LEU A 135
LEU A 138
GLU A 269
 None
 1.00A 5y7pG-5gs7A:
48.6		 5y7pG-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		6 / 10 ILE A  58
LEU A  63
ASN A  79
PHE A  99
LEU A 135
LEU A 138
 None
 1.05A 5y7pH-5gs7A:
48.7		 5y7pH-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 5gs7 CHOLOYLGLYCINE
HYDROLASE
(Enterococcus
faecalis) 		6 / 10 TYR A  24
ILE A  58
LEU A  63
ASN A  79
LEU A 135
LEU A 138
 None
 1.11A 5y7pH-5gs7A:
48.7		 5y7pH-5gs7A:
53.82