SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gsb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5gsb H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-D ALPHA
CHAIN
(Mus
musculus) 		4 / 5 LEU A 160
GLU A 163
ALA A 158
LEU A 130
 None
 1.16A 1eta1-5gsbA:
undetectable		 1eta1-5gsbA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5gsb H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-D ALPHA
CHAIN
(Mus
musculus) 		4 / 6 LEU A 160
GLU A 163
ALA A 158
LEU A 130
 None
 1.16A 1etb1-5gsbA:
undetectable		 1etb1-5gsbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5gsb H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-D ALPHA
CHAIN
(Mus
musculus) 		4 / 4 THR A 178
LEU A 179
VAL A  28
LEU A   5
 None
 1.04A 1fbmB-5gsbA:
undetectable		 1fbmB-5gsbA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 5gsb H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-D ALPHA
CHAIN
(Mus
musculus) 		5 / 12 ILE A 213
ASP A 212
THR A 214
VAL A 261
PRO A 185
 None
 1.27A 2yzqA-5gsbA:
undetectable		 2yzqA-5gsbA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5gsb H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-D ALPHA
CHAIN
(Mus
musculus) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.97A 2zm8A-5gsbA:
undetectable		 2zm8A-5gsbA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5gsb H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-D ALPHA
CHAIN
(Mus
musculus) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 1.02A 2zmaA-5gsbA:
undetectable		 2zmaA-5gsbA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5gsb H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-D ALPHA
CHAIN
(Mus
musculus) 		3 / 3 TYR A 156
PHE A  74
ARG A  97
 None
 1.01A 4g19D-5gsbA:
undetectable		 4g19D-5gsbA:
22.11