SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gsl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 248
ALA A 451
GLY A 456
TYR A 457
PHE A 515
 None
 1.33A 1brpA-5gslA:
undetectable		 1brpA-5gslA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 664
MET A 484
VAL A 680
LEU A 324
 None
 0.94A 1dzmA-5gslA:
undetectable		 1dzmA-5gslA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 481
LEU A 645
LEU A 369
LEU A 365
 None
 0.89A 1errA-5gslA:
undetectable		 1errA-5gslA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 472
PHE A 473
LEU A 478
VAL A 487
VAL A 491
 None
 1.26A 1hrkB-5gslA:
2.9		 1hrkB-5gslA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 105
ASN A 396
TRP A 400
 PO4  A 802 (-2.8A)
None
None
 1.22A 1r15C-5gslA:
1.7		 1r15C-5gslA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 105
ASN A 396
TRP A 400
 PO4  A 802 (-2.8A)
None
None
 1.22A 1r15D-5gslA:
undetectable		 1r15D-5gslA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 105
ASN A 396
TRP A 400
 PO4  A 802 (-2.8A)
None
None
 1.23A 1r15E-5gslA:
undetectable		 1r15E-5gslA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 105
ASN A 396
TRP A 400
 PO4  A 802 (-2.8A)
None
None
 1.22A 1r15F-5gslA:
1.9		 1r15F-5gslA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 524
ALA A 442
MET A 502
LEU A 499
ASP A 493
 None
 1.24A 1rlbE-5gslA:
undetectable		 1rlbE-5gslA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 294
HIS A 252
ILE A 255
 None
 0.62A 1s9pB-5gslA:
undetectable		 1s9pB-5gslA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.13A 1v55C-5gslA:
undetectable
1v55N-5gslA:
undetectable
1v55P-5gslA:
undetectable		 1v55C-5gslA:
14.85
1v55N-5gslA:
20.36
1v55P-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 SER A 435
PHE A 437
ALA A 439
ARG A 440
 None
 1.08A 2bxkA-5gslA:
undetectable		 2bxkA-5gslA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 TYR A 184
TYR A 147
TYR A 261
HIS A 144
 None
 1.47A 2ha2A-5gslA:
undetectable		 2ha2A-5gslA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 472
PHE A 473
LEU A 478
VAL A 487
VAL A 491
 None
 1.29A 2pnjB-5gslA:
3.0		 2pnjB-5gslA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 472
PHE A 473
LEU A 478
VAL A 487
VAL A 491
 None
 1.20A 2po5A-5gslA:
3.0		 2po5A-5gslA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 472
PHE A 473
LEU A 478
VAL A 487
VAL A 491
 None
 1.23A 2po5B-5gslA:
undetectable		 2po5B-5gslA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 472
PHE A 473
LEU A 478
VAL A 487
VAL A 491
 None
 1.22A 2qd4B-5gslA:
undetectable		 2qd4B-5gslA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 ASN A 169
LEU A 166
SER A 168
VAL A 275
 None
 0.94A 2uz2A-5gslA:
undetectable		 2uz2A-5gslA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 468
ASN A 469
GLU A 475
MET A 445
 None
 1.00A 2w8yA-5gslA:
undetectable		 2w8yA-5gslA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.20A 2y69C-5gslA:
undetectable
2y69N-5gslA:
undetectable
2y69P-5gslA:
undetectable		 2y69C-5gslA:
14.85
2y69N-5gslA:
20.36
2y69P-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 265
ILE A 178
PRO A  98
VAL A 135
 None
 1.13A 2ygoA-5gslA:
undetectable		 2ygoA-5gslA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ0_A_ACRA801_1
(ALPHA-GLUCOSIDASE
(ALPHA-GLUCOSIDASE
SUSB))		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 181
SER A 183
PHE A 189
GLU A 349
GLU A 308
 PO4  A 802 (-3.4A)
None
None
PO4  A 802 (-3.6A)
PO4  A 802 ( 4.4A)
 1.47A 2zq0A-5gslA:
6.1		 2zq0A-5gslA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ0_B_ACRB811_1
(ALPHA-GLUCOSIDASE
(ALPHA-GLUCOSIDASE
SUSB))		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 181
SER A 183
PHE A 189
GLU A 349
GLU A 308
 PO4  A 802 (-3.4A)
None
None
PO4  A 802 (-3.6A)
PO4  A 802 ( 4.4A)
 1.48A 2zq0B-5gslA:
1.9		 2zq0B-5gslA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.17A 3ablC-5gslA:
undetectable
3ablN-5gslA:
undetectable
3ablP-5gslA:
undetectable		 3ablC-5gslA:
14.85
3ablN-5gslA:
20.36
3ablP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.13A 3abmA-5gslA:
undetectable
3abmC-5gslA:
undetectable
3abmP-5gslA:
undetectable		 3abmA-5gslA:
20.36
3abmC-5gslA:
14.85
3abmP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 472
PHE A 473
LEU A 478
VAL A 487
VAL A 491
 None
 1.22A 3aqiB-5gslA:
undetectable		 3aqiB-5gslA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.14A 3asnC-5gslA:
undetectable
3asnN-5gslA:
undetectable
3asnP-5gslA:
undetectable		 3asnC-5gslA:
14.85
3asnN-5gslA:
20.36
3asnP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.12A 3asoA-5gslA:
undetectable
3asoC-5gslA:
undetectable
3asoP-5gslA:
undetectable		 3asoA-5gslA:
20.36
3asoC-5gslA:
14.85
3asoP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.15A 3asoC-5gslA:
undetectable
3asoN-5gslA:
undetectable
3asoP-5gslA:
undetectable		 3asoC-5gslA:
14.85
3asoN-5gslA:
20.36
3asoP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 354
GLU A 105
TRP A 400
SER A 353
 None
PO4  A 802 (-2.8A)
None
None
 1.11A 3dzgA-5gslA:
undetectable		 3dzgA-5gslA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 354
GLU A 105
TRP A 400
SER A 353
 None
PO4  A 802 (-2.8A)
None
None
 1.10A 3dzgB-5gslA:
2.2		 3dzgB-5gslA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 111
PRO A 112
TYR A 261
GLY A  99
 None
 0.93A 3em0B-5gslA:
undetectable		 3em0B-5gslA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 104
GLY A 109
ASN A 259
VAL A 262
ASP A 180
 PO4  A 802 (-3.9A)
None
None
None
None
 0.98A 3embA-5gslA:
undetectable		 3embA-5gslA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 TYR A 295
TYR A 283
ILE A 255
 None
 0.76A 3eteA-5gslA:
undetectable
3eteB-5gslA:
undetectable		 3eteA-5gslA:
21.47
3eteB-5gslA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 354
GLU A 105
TRP A 400
SER A 353
 None
PO4  A 802 (-2.8A)
None
None
 1.22A 3i9jB-5gslA:
undetectable		 3i9jB-5gslA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 TRP A 400
LEU A 354
TRP A 310
ASN A 396
 None
None
PO4  A 802 (-3.9A)
None
 1.39A 3k8mA-5gslA:
12.6		 3k8mA-5gslA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 TRP A 400
LEU A 354
TRP A 310
ASN A 396
 None
None
PO4  A 802 (-3.9A)
None
 1.38A 3k8mB-5gslA:
12.6		 3k8mB-5gslA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 291
GLU A 213
ASN A 214
 None
 0.89A 3lp9B-5gslA:
undetectable
3lp9D-5gslA:
undetectable		 3lp9B-5gslA:
14.82
3lp9D-5gslA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 ARG A 163
VAL A 273
TYR A 167
ILE A 173
 None
 1.05A 3remA-5gslA:
undetectable		 3remA-5gslA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 354
GLU A 105
TRP A 400
SER A 353
 None
PO4  A 802 (-2.8A)
None
None
 1.07A 3ropA-5gslA:
2.2		 3ropA-5gslA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 408
GLY A 385
GLY A 386
THR A 399
 None
 0.94A 3si7A-5gslA:
undetectable		 3si7A-5gslA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A  90
GLY A  91
MET A  44
PHE A  83
 None
 1.46A 3vaqB-5gslA:
2.2		 3vaqB-5gslA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 472
PHE A 473
LEU A 478
VAL A 487
VAL A 491
 None
 1.23A 3w1wA-5gslA:
3.0		 3w1wA-5gslA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 472
PHE A 473
LEU A 478
VAL A 487
VAL A 491
 None
 1.31A 3w1wB-5gslA:
3.0		 3w1wB-5gslA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.14A 3wg7A-5gslA:
undetectable
3wg7C-5gslA:
undetectable
3wg7P-5gslA:
undetectable		 3wg7A-5gslA:
20.36
3wg7C-5gslA:
14.85
3wg7P-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.18A 3wg7C-5gslA:
undetectable
3wg7N-5gslA:
undetectable
3wg7P-5gslA:
undetectable		 3wg7C-5gslA:
14.85
3wg7N-5gslA:
20.36
3wg7P-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.12A 3x2qA-5gslA:
undetectable
3x2qC-5gslA:
undetectable
3x2qP-5gslA:
undetectable		 3x2qA-5gslA:
20.36
3x2qC-5gslA:
14.85
3x2qP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.15A 3x2qC-5gslA:
undetectable
3x2qN-5gslA:
undetectable
3x2qP-5gslA:
undetectable		 3x2qC-5gslA:
14.85
3x2qN-5gslA:
20.36
3x2qP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 444
PHE A 443
TYR A 449
ASN A 467
LEU A 479
 None
 1.28A 4a83A-5gslA:
undetectable		 4a83A-5gslA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 ASN A 379
GLU A 308
ILE A 348
ASP A 180
 None
PO4  A 802 ( 4.4A)
None
None
 0.88A 4d39A-5gslA:
undetectable		 4d39A-5gslA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 ASN A 379
GLU A 308
ILE A 348
ASP A 180
 None
PO4  A 802 ( 4.4A)
None
None
 0.93A 4d39B-5gslA:
undetectable		 4d39B-5gslA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 TYR A 295
HIS A 299
ARG A 298
 None
 1.11A 4e7bC-5gslA:
undetectable		 4e7bC-5gslA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 579
ARG A 585
ASP A 606
 None
 0.83A 4fp9C-5gslA:
undetectable		 4fp9C-5gslA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 579
ARG A 585
ASP A 606
 None
 0.81A 4fp9F-5gslA:
undetectable		 4fp9F-5gslA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 6 PRO A 100
TYR A 147
TYR A 261
TYR A 142
 None
 1.11A 4g10A-5gslA:
undetectable		 4g10A-5gslA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A  95
THR A 177
VAL A  21
ASP A   9
 None
 0.90A 4iaqA-5gslA:
undetectable		 4iaqA-5gslA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 375
THR A 331
VAL A  21
ASP A   9
 None
 1.41A 4iarA-5gslA:
undetectable		 4iarA-5gslA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 TYR A 449
VAL A 466
LEU A 248
LEU A 244
 None
 1.10A 4jtrA-5gslA:
9.1		 4jtrA-5gslA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 6 VAL A 700
VAL A 671
ILE A 664
LEU A 324
 None
 0.97A 4l1wB-5gslA:
10.1		 4l1wB-5gslA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 341
LYS A 342
THR A 343
 None
 0.58A 4lj0A-5gslA:
undetectable		 4lj0A-5gslA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.12A 5b1aA-5gslA:
undetectable
5b1aC-5gslA:
undetectable
5b1aP-5gslA:
undetectable		 5b1aA-5gslA:
20.36
5b1aC-5gslA:
14.85
5b1aP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.11A 5b1bA-5gslA:
undetectable
5b1bC-5gslA:
undetectable
5b1bP-5gslA:
undetectable		 5b1bA-5gslA:
20.36
5b1bC-5gslA:
14.85
5b1bP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.12A 5b3sA-5gslA:
undetectable
5b3sC-5gslA:
undetectable
5b3sP-5gslA:
undetectable		 5b3sA-5gslA:
20.36
5b3sC-5gslA:
14.85
5b3sP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 385
GLY A 407
ASP A 401
LEU A  27
LEU A 382
 None
 1.07A 5bw4A-5gslA:
undetectable		 5bw4A-5gslA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 280
TYR A 337
ILE A 492
TYR A 336
PHE A 329
 None
 1.23A 5eshA-5gslA:
undetectable		 5eshA-5gslA:
22.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GSM_A_GCSA801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 CYH A 103
GLY A 104
GLU A 105
GLU A 186
LEU A 284
 PO4  A 802 (-3.1A)
PO4  A 802 (-3.9A)
PO4  A 802 (-2.8A)
None
None
 1.24A 5gsmA-5gslA:
63.3		 5gsmA-5gslA:
62.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GSM_A_GCSA801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 104
GLU A 105
GLU A 186
LEU A 284
GLU A 181
 PO4  A 802 (-3.9A)
PO4  A 802 (-2.8A)
None
None
PO4  A 802 (-3.4A)
 1.45A 5gsmA-5gslA:
63.3		 5gsmA-5gslA:
62.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GSM_A_GCSA801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		12 / 12 TYR A  55
CYH A 103
GLY A 104
GLU A 105
ASP A 180
GLU A 181
LEU A 280
GLU A 308
TRP A 310
GLU A 349
TYR A 381
TRP A 400
 None
PO4  A 802 (-3.1A)
PO4  A 802 (-3.9A)
PO4  A 802 (-2.8A)
None
PO4  A 802 (-3.4A)
None
PO4  A 802 ( 4.4A)
PO4  A 802 (-3.9A)
PO4  A 802 (-3.6A)
PO4  A 802 (-4.2A)
None
 0.46A 5gsmA-5gslA:
63.3		 5gsmA-5gslA:
62.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GSM_B_GCSB801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 CYH A 103
GLY A 104
GLU A 105
GLU A 186
LEU A 284
 PO4  A 802 (-3.1A)
PO4  A 802 (-3.9A)
PO4  A 802 (-2.8A)
None
None
 1.26A 5gsmB-5gslA:
63.7		 5gsmB-5gslA:
62.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GSM_B_GCSB801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 104
GLU A 105
GLU A 186
LEU A 284
GLU A 181
 PO4  A 802 (-3.9A)
PO4  A 802 (-2.8A)
None
None
PO4  A 802 (-3.4A)
 1.45A 5gsmB-5gslA:
63.7		 5gsmB-5gslA:
62.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GSM_B_GCSB801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		12 / 12 TYR A  55
CYH A 103
GLY A 104
GLU A 105
ASP A 180
GLU A 181
LEU A 280
GLU A 308
TRP A 310
GLU A 349
TYR A 381
TRP A 400
 None
PO4  A 802 (-3.1A)
PO4  A 802 (-3.9A)
PO4  A 802 (-2.8A)
None
PO4  A 802 (-3.4A)
None
PO4  A 802 ( 4.4A)
PO4  A 802 (-3.9A)
PO4  A 802 (-3.6A)
PO4  A 802 (-4.2A)
None
 0.44A 5gsmB-5gslA:
63.7		 5gsmB-5gslA:
62.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GSM_B_GCSB801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 101
GLU A 105
GLU A 186
LEU A 284
GLU A 181
 None
PO4  A 802 (-2.8A)
None
None
PO4  A 802 (-3.4A)
 1.46A 5gsmB-5gslA:
63.7		 5gsmB-5gslA:
62.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 406
GLY A 407
HIS A  47
GLU A 417
ILE A 358
 None
 1.33A 5igwA-5gslA:
undetectable		 5igwA-5gslA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 406
GLY A 385
HIS A  47
GLU A 417
ILE A 358
 None
 0.86A 5igyA-5gslA:
undetectable		 5igyA-5gslA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 6 PHE A 489
PRO A 488
ARG A 335
THR A 331
 None
 1.20A 5ih0A-5gslA:
undetectable		 5ih0A-5gslA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 6 TYR A  29
HIS A  61
ILE A 162
TYR A 165
 None
 1.30A 5ih0A-5gslA:
undetectable		 5ih0A-5gslA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.14A 5iy5C-5gslA:
undetectable
5iy5N-5gslA:
undetectable
5iy5P-5gslA:
undetectable		 5iy5C-5gslA:
14.72
5iy5N-5gslA:
20.36
5iy5P-5gslA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 TYR A 334
SER A 347
TRP A 289
 None
 1.06A 5n8jB-5gslA:
undetectable		 5n8jB-5gslA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 346
LEU A 280
PHE A 309
SER A 347
GLU A 349
 None
None
None
None
PO4  A 802 (-3.6A)
 1.41A 5tixB-5gslA:
undetectable		 5tixB-5gslA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.11A 5wauA-5gslA:
undetectable
5wauC-5gslA:
undetectable
5wauc-5gslA:
undetectable		 5wauA-5gslA:
20.36
5wauC-5gslA:
14.85
5wauc-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.15A 5wauC-5gslA:
undetectable
5waua-5gslA:
undetectable
5wauc-5gslA:
undetectable		 5wauC-5gslA:
14.85
5waua-5gslA:
20.36
5wauc-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.21A 5x1fA-5gslA:
undetectable
5x1fC-5gslA:
undetectable
5x1fP-5gslA:
undetectable		 5x1fA-5gslA:
20.36
5x1fC-5gslA:
14.85
5x1fP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.15A 5xdqA-5gslA:
undetectable
5xdqC-5gslA:
undetectable
5xdqP-5gslA:
undetectable		 5xdqA-5gslA:
20.36
5xdqC-5gslA:
14.85
5xdqP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.16A 5xdqC-5gslA:
undetectable
5xdqN-5gslA:
undetectable
5xdqP-5gslA:
undetectable		 5xdqC-5gslA:
14.85
5xdqN-5gslA:
20.36
5xdqP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.14A 5xdxC-5gslA:
undetectable
5xdxN-5gslA:
undetectable
5xdxP-5gslA:
undetectable		 5xdxC-5gslA:
14.72
5xdxN-5gslA:
20.36
5xdxP-5gslA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.16A 5z84A-5gslA:
undetectable
5z84C-5gslA:
undetectable
5z84P-5gslA:
undetectable		 5z84A-5gslA:
20.36
5z84C-5gslA:
14.85
5z84P-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.16A 5z84C-5gslA:
undetectable
5z84N-5gslA:
undetectable
5z84P-5gslA:
undetectable		 5z84C-5gslA:
14.85
5z84N-5gslA:
20.36
5z84P-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.13A 5z85A-5gslA:
undetectable
5z85C-5gslA:
undetectable
5z85P-5gslA:
undetectable		 5z85A-5gslA:
20.36
5z85C-5gslA:
14.85
5z85P-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.14A 5z85C-5gslA:
undetectable
5z85N-5gslA:
undetectable
5z85P-5gslA:
undetectable		 5z85C-5gslA:
14.85
5z85N-5gslA:
20.36
5z85P-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.13A 5z86A-5gslA:
undetectable
5z86C-5gslA:
undetectable
5z86P-5gslA:
undetectable		 5z86A-5gslA:
20.36
5z86C-5gslA:
14.85
5z86P-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.14A 5z86C-5gslA:
undetectable
5z86N-5gslA:
undetectable
5z86P-5gslA:
undetectable		 5z86C-5gslA:
14.85
5z86N-5gslA:
20.36
5z86P-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.16A 5zcoA-5gslA:
undetectable
5zcoC-5gslA:
undetectable
5zcoP-5gslA:
undetectable		 5zcoA-5gslA:
20.36
5zcoC-5gslA:
14.85
5zcoP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.16A 5zcoC-5gslA:
undetectable
5zcoN-5gslA:
undetectable
5zcoP-5gslA:
undetectable		 5zcoC-5gslA:
14.85
5zcoN-5gslA:
20.36
5zcoP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.16A 5zcpA-5gslA:
undetectable
5zcpC-5gslA:
undetectable
5zcpP-5gslA:
undetectable		 5zcpA-5gslA:
20.36
5zcpC-5gslA:
14.85
5zcpP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 382
HIS A  61
THR A  54
TYR A  55
 None
 1.17A 5zcpC-5gslA:
undetectable
5zcpN-5gslA:
undetectable
5zcpP-5gslA:
undetectable		 5zcpC-5gslA:
14.85
5zcpN-5gslA:
20.36
5zcpP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
THR A  54
TYR A  55
LEU A 382
 None
 1.12A 5zcqA-5gslA:
undetectable
5zcqC-5gslA:
undetectable
5zcqP-5gslA:
undetectable		 5zcqA-5gslA:
20.36
5zcqC-5gslA:
14.85
5zcqP-5gslA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		5 / 7 GLN A 648
GLY A 624
PHE A 625
GLY A 610
VAL A 595
 None
 1.20A 6ekzA-5gslA:
undetectable		 6ekzA-5gslA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE
(Pyrococcus
horikoshii) 		4 / 5 LEU A 382
TYR A 381
ILE A 162
GLY A 104
 None
PO4  A 802 (-4.2A)
None
PO4  A 802 (-3.9A)
 1.03A 6hd6A-5gslA:
undetectable		 6hd6A-5gslA:
9.25