SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gsm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 LEU A 443
LEU A 504
LEU A 478
LEU A 549
 PPI  A 808 (-4.0A)
None
None
None
 0.69A 1errA-5gsmA:
undetectable		 1errA-5gsmA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 12 PRO A 412
GLY A 383
GLY A 408
ASP A 407
VAL A  30
 None
 1.14A 1ffyA-5gsmA:
undetectable		 1ffyA-5gsmA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 12 PRO A 412
GLY A 383
GLY A 408
ASP A 407
VAL A  30
 None
 1.14A 1qu2A-5gsmA:
undetectable		 1qu2A-5gsmA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		3 / 3 GLU A 103
ASN A 394
TRP A 398
 GCS  A 801 (-2.9A)
None
None
 1.24A 1r15C-5gsmA:
2.2		 1r15C-5gsmA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		3 / 3 GLU A 103
ASN A 394
TRP A 398
 GCS  A 801 (-2.9A)
None
None
 1.22A 1r15D-5gsmA:
2.4		 1r15D-5gsmA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		3 / 3 GLU A 103
ASN A 394
TRP A 398
 GCS  A 801 (-2.9A)
None
None
 1.23A 1r15E-5gsmA:
2.4		 1r15E-5gsmA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		3 / 3 GLU A 103
ASN A 394
TRP A 398
 GCS  A 801 (-2.9A)
None
None
 1.24A 1r15F-5gsmA:
2.5		 1r15F-5gsmA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		3 / 3 ARG A 266
ARG A 269
ILE A 275
 None
 0.82A 1uobA-5gsmA:
undetectable		 1uobA-5gsmA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A  25
GLN A  26
PHE A  27
LEU A  39
 None
 0.98A 1v55C-5gsmA:
undetectable
1v55J-5gsmA:
undetectable		 1v55C-5gsmA:
16.50
1v55J-5gsmA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A 380
HIS A  59
THR A  52
TYR A  53
 None
None
None
GCS  A 801 (-4.8A)
 1.19A 1v55C-5gsmA:
undetectable
1v55N-5gsmA:
undetectable
1v55P-5gsmA:
undetectable		 1v55C-5gsmA:
16.50
1v55N-5gsmA:
21.26
1v55P-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 4 GLY A 704
SER A 366
VAL A 672
LEU A 740
 None
 1.31A 1yajB-5gsmA:
undetectable		 1yajB-5gsmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A  25
GLN A  26
PHE A  27
LEU A  39
 None
 0.90A 2dysP-5gsmA:
undetectable
2dysW-5gsmA:
undetectable		 2dysP-5gsmA:
16.50
2dysW-5gsmA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A  25
GLN A  26
PHE A  27
LEU A  39
 None
 0.98A 2eijC-5gsmA:
undetectable
2eijJ-5gsmA:
undetectable		 2eijC-5gsmA:
16.50
2eijJ-5gsmA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A  25
GLN A  26
PHE A  27
LEU A  39
 None
 0.98A 2eimC-5gsmA:
undetectable
2eimJ-5gsmA:
undetectable		 2eimC-5gsmA:
16.50
2eimJ-5gsmA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A  25
GLN A  26
PHE A  27
LEU A  39
 None
 0.95A 2einC-5gsmA:
undetectable
2einJ-5gsmA:
undetectable		 2einC-5gsmA:
16.50
2einJ-5gsmA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 LEU A  25
GLN A  26
PHE A  27
LEU A  39
 None
 0.97A 2einP-5gsmA:
undetectable
2einW-5gsmA:
undetectable		 2einP-5gsmA:
16.50
2einW-5gsmA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		3 / 3 LYS A 438
ARG A 647
VAL A 646
 None
 0.71A 2r2vC-5gsmA:
undetectable
2r2vD-5gsmA:
undetectable		 2r2vC-5gsmA:
5.72
2r2vD-5gsmA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 LEU A  25
GLN A  26
PHE A  27
LEU A  39
 None
 0.99A 2zxwP-5gsmA:
undetectable
2zxwW-5gsmA:
undetectable		 2zxwP-5gsmA:
16.50
2zxwW-5gsmA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.19A 3abmA-5gsmA:
undetectable
3abmC-5gsmA:
undetectable
3abmP-5gsmA:
undetectable		 3abmA-5gsmA:
21.26
3abmC-5gsmA:
16.50
3abmP-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 LEU A  25
GLN A  26
PHE A  27
LEU A  39
 None
 0.95A 3ag1C-5gsmA:
undetectable
3ag1J-5gsmA:
undetectable		 3ag1C-5gsmA:
16.50
3ag1J-5gsmA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A  25
GLN A  26
PHE A  27
LEU A  39
 None
 1.00A 3ag2C-5gsmA:
undetectable		 3ag2C-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A  25
GLN A  26
PHE A  27
LEU A  39
 None
 0.94A 3ag2P-5gsmA:
undetectable
3ag2W-5gsmA:
undetectable		 3ag2P-5gsmA:
16.50
3ag2W-5gsmA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 GLY A 578
ASP A 631
TRP A 638
ARG A 634
 None
 1.22A 3arrA-5gsmA:
9.8		 3arrA-5gsmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 LEU A 380
HIS A  59
THR A  52
TYR A  53
 None
None
None
GCS  A 801 (-4.8A)
 1.21A 3asnC-5gsmA:
undetectable
3asnN-5gsmA:
undetectable
3asnP-5gsmA:
undetectable		 3asnC-5gsmA:
16.50
3asnN-5gsmA:
21.26
3asnP-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.19A 3asoA-5gsmA:
undetectable
3asoC-5gsmA:
undetectable
3asoP-5gsmA:
undetectable		 3asoA-5gsmA:
21.26
3asoC-5gsmA:
16.50
3asoP-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 SER A 310
GLN A 349
VAL A 416
HIS A 413
 None
 1.15A 3b9lA-5gsmA:
undetectable		 3b9lA-5gsmA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 12 ALA A 576
LEU A 640
GLN A 644
LEU A 533
PHE A 621
 PPI  A 809 (-3.2A)
None
None
None
None
 1.19A 3datA-5gsmA:
undetectable		 3datA-5gsmA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A 352
GLU A 103
TRP A 398
SER A 351
 GCS  A 801 (-4.9A)
GCS  A 801 (-2.9A)
None
None
 1.13A 3dzgA-5gsmA:
undetectable		 3dzgA-5gsmA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A 352
GLU A 103
TRP A 398
SER A 351
 GCS  A 801 (-4.9A)
GCS  A 801 (-2.9A)
None
None
 1.11A 3dzgB-5gsmA:
2.2		 3dzgB-5gsmA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 11 TYR A 332
VAL A 336
TYR A 365
ILE A 376
ILE A 346
 None
 1.48A 3ganA-5gsmA:
undetectable		 3ganA-5gsmA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 LEU A 352
GLU A 103
TRP A 398
SER A 351
 GCS  A 801 (-4.9A)
GCS  A 801 (-2.9A)
None
None
 1.22A 3i9jB-5gsmA:
2.1		 3i9jB-5gsmA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 TRP A 398
LEU A 352
TRP A 308
ASN A 394
 None
GCS  A 801 (-4.9A)
GCS  A 801 ( 3.9A)
None
 1.38A 3k8mA-5gsmA:
12.7		 3k8mA-5gsmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 TRP A 398
LEU A 352
TRP A 308
ASN A 394
 None
GCS  A 801 (-4.9A)
GCS  A 801 ( 3.9A)
None
 1.37A 3k8mB-5gsmA:
12.3		 3k8mB-5gsmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 5 TYR A 327
GLN A 284
ILE A 186
LEU A 283
 None
 0.97A 3ls4L-5gsmA:
undetectable		 3ls4L-5gsmA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 TYR A 507
ASN A 451
LEU A 464
ASP A 463
 None
None
PPI  A 808 ( 4.7A)
None
 1.40A 3lslG-5gsmA:
undetectable		 3lslG-5gsmA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 LEU A 363
PHE A 317
ILE A 325
THR A 476
 None
 1.09A 3mdrA-5gsmA:
undetectable		 3mdrA-5gsmA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A 322
THR A 673
THR A 329
LEU A 435
LEU A 660
 None
 1.45A 3n58D-5gsmA:
2.3		 3n58D-5gsmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A  40
ARG A  43
GLY A  23
THR A  24
LEU A  88
 None
 1.33A 3okxB-5gsmA:
undetectable		 3okxB-5gsmA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 10 ALA A 616
LEU A 619
ILE A 597
VAL A 574
VAL A 588
 None
None
PPI  A 809 ( 4.2A)
None
None
 1.44A 3r9cA-5gsmA:
undetectable		 3r9cA-5gsmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 LEU A 352
GLU A 103
TRP A 398
SER A 351
 GCS  A 801 (-4.9A)
GCS  A 801 (-2.9A)
None
None
 1.07A 3ropA-5gsmA:
2.5		 3ropA-5gsmA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 ASN A 257
HIS A 249
GLU A 491
GLU A 515
 None
 1.15A 3sg9B-5gsmA:
undetectable		 3sg9B-5gsmA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 4 LEU A 406
GLY A 383
GLY A 384
THR A 397
 None
 0.96A 3si7A-5gsmA:
undetectable		 3si7A-5gsmA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 11 ILE A 176
PHE A 157
ILE A 160
GLU A 270
VAL A 273
 None
 1.11A 3tmzA-5gsmA:
undetectable		 3tmzA-5gsmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 4 LEU A  88
GLY A  89
MET A  42
PHE A  81
 None
 1.38A 3vaqB-5gsmA:
undetectable		 3vaqB-5gsmA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.20A 3wg7A-5gsmA:
undetectable
3wg7C-5gsmA:
undetectable
3wg7P-5gsmA:
undetectable		 3wg7A-5gsmA:
21.26
3wg7C-5gsmA:
16.50
3wg7P-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.19A 3x2qA-5gsmA:
undetectable
3x2qC-5gsmA:
undetectable
3x2qP-5gsmA:
undetectable		 3x2qA-5gsmA:
21.26
3x2qC-5gsmA:
16.50
3x2qP-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 THR A  24
GLY A  23
ARG A 411
ILE A 417
 None
 1.06A 4acbC-5gsmA:
undetectable		 4acbC-5gsmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 TYR A 182
ILE A 198
VAL A 234
GLY A 124
 None
 0.76A 4eq4B-5gsmA:
undetectable		 4eq4B-5gsmA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 PRO A  98
TYR A 145
TYR A 259
TYR A 140
 None
 1.03A 4g10A-5gsmA:
undetectable		 4g10A-5gsmA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		3 / 3 ASP A 279
TRP A 398
SER A 345
 None
 0.85A 4lrhA-5gsmA:
undetectable		 4lrhA-5gsmA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		3 / 3 TYR A 153
GLY A  97
PRO A  98
 None
 0.69A 4qwpA-5gsmA:
undetectable		 4qwpA-5gsmA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.18A 5b1aA-5gsmA:
undetectable
5b1aC-5gsmA:
undetectable
5b1aP-5gsmA:
undetectable		 5b1aA-5gsmA:
21.26
5b1aC-5gsmA:
16.50
5b1aP-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.19A 5b3sA-5gsmA:
undetectable
5b3sC-5gsmA:
undetectable
5b3sP-5gsmA:
undetectable		 5b3sA-5gsmA:
21.26
5b3sC-5gsmA:
16.50
5b3sP-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 383
GLY A 405
ASP A 399
LEU A  25
LEU A 380
 None
 1.06A 5bw4A-5gsmA:
undetectable		 5bw4A-5gsmA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 HIS A 335
ALA A 440
LEU A 504
TYR A 444
 None
 1.06A 5igiA-5gsmA:
undetectable		 5igiA-5gsmA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 6 PHE A 485
PRO A 484
ARG A 333
THR A 329
 None
 1.35A 5ih0A-5gsmA:
undetectable		 5ih0A-5gsmA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 4 GLU A 179
PRO A 280
ILE A 277
LEU A 278
 GCS  A 801 (-2.3A)
None
None
None
 1.17A 5m45A-5gsmA:
undetectable		 5m45A-5gsmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 4 GLU A 179
PRO A 280
ILE A 277
LEU A 278
 GCS  A 801 (-2.3A)
None
None
None
 1.19A 5m45D-5gsmA:
undetectable		 5m45D-5gsmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 4 GLU A 179
PRO A 280
ILE A 277
LEU A 278
 GCS  A 801 (-2.3A)
None
None
None
 1.16A 5m45G-5gsmA:
undetectable		 5m45G-5gsmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 4 GLU A 179
PRO A 280
ILE A 277
LEU A 278
 GCS  A 801 (-2.3A)
None
None
None
 1.23A 5m45J-5gsmA:
0.0		 5m45J-5gsmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		3 / 3 HIS A 249
HIS A 250
HIS A 289
 None
 0.82A 5oexA-5gsmA:
undetectable		 5oexA-5gsmA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 9 LEU A 785
VAL A 719
LEU A 748
PRO A 709
ALA A 722
 None
 1.13A 5og9A-5gsmA:
undetectable		 5og9A-5gsmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A 785
VAL A 719
LEU A 748
PRO A 709
ALA A 722
 None
 1.14A 5og9B-5gsmA:
undetectable		 5og9B-5gsmA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 10 LEU A 344
LEU A 278
PHE A 307
SER A 345
GLU A 347
 None
None
None
None
GCS  A 801 (-2.7A)
 1.35A 5tixB-5gsmA:
undetectable		 5tixB-5gsmA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		5 / 12 TYR A  53
ILE A  93
PHE A  28
GLY A  23
LEU A 380
 GCS  A 801 (-4.8A)
None
None
None
None
 1.41A 5v5zA-5gsmA:
undetectable		 5v5zA-5gsmA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 ARG A  95
VAL A  50
ASP A  51
TYR A 379
 None
None
None
GCS  A 801 (-4.2A)
 0.94A 5vlmA-5gsmA:
undetectable		 5vlmA-5gsmA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.17A 5wauA-5gsmA:
undetectable
5wauC-5gsmA:
undetectable
5wauc-5gsmA:
undetectable		 5wauA-5gsmA:
21.26
5wauC-5gsmA:
16.50
5wauc-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A 380
HIS A  59
THR A  52
TYR A  53
 None
None
None
GCS  A 801 (-4.8A)
 1.22A 5wauC-5gsmA:
undetectable
5waua-5gsmA:
undetectable
5wauc-5gsmA:
undetectable		 5wauC-5gsmA:
16.50
5waua-5gsmA:
21.26
5wauc-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		3 / 3 LYS A  36
LEU A  88
ARG A  43
 None
 0.87A 5yw0A-5gsmA:
undetectable		 5yw0A-5gsmA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A 380
HIS A  59
THR A  52
TYR A  53
 None
None
None
GCS  A 801 (-4.8A)
 1.22A 5z84C-5gsmA:
undetectable
5z84N-5gsmA:
undetectable
5z84P-5gsmA:
undetectable		 5z84C-5gsmA:
16.50
5z84N-5gsmA:
21.26
5z84P-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.20A 5z85A-5gsmA:
undetectable
5z85C-5gsmA:
undetectable
5z85P-5gsmA:
undetectable		 5z85A-5gsmA:
21.26
5z85C-5gsmA:
16.50
5z85P-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A  25
GLN A  26
PHE A  27
LEU A  39
 None
 0.95A 5z85C-5gsmA:
undetectable
5z85J-5gsmA:
undetectable		 5z85C-5gsmA:
16.50
5z85J-5gsmA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A 380
HIS A  59
THR A  52
TYR A  53
 None
None
None
GCS  A 801 (-4.8A)
 1.20A 5z85C-5gsmA:
undetectable
5z85N-5gsmA:
undetectable
5z85P-5gsmA:
undetectable		 5z85C-5gsmA:
16.50
5z85N-5gsmA:
21.26
5z85P-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.20A 5z86A-5gsmA:
undetectable
5z86C-5gsmA:
undetectable
5z86P-5gsmA:
undetectable		 5z86A-5gsmA:
21.26
5z86C-5gsmA:
16.50
5z86P-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 LEU A 380
HIS A  59
THR A  52
TYR A  53
 None
None
None
GCS  A 801 (-4.8A)
 1.21A 5z86C-5gsmA:
undetectable
5z86N-5gsmA:
undetectable
5z86P-5gsmA:
undetectable		 5z86C-5gsmA:
16.50
5z86N-5gsmA:
21.26
5z86P-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.22A 5zcoA-5gsmA:
undetectable
5zcoC-5gsmA:
undetectable
5zcoP-5gsmA:
undetectable		 5zcoA-5gsmA:
21.26
5zcoC-5gsmA:
16.50
5zcoP-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  59
THR A  52
TYR A  53
LEU A 380
 None
None
GCS  A 801 (-4.8A)
None
 1.19A 5zcqA-5gsmA:
undetectable
5zcqC-5gsmA:
undetectable
5zcqP-5gsmA:
undetectable		 5zcqA-5gsmA:
21.26
5zcqC-5gsmA:
16.50
5zcqP-5gsmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5gsm EXO-BETA-D-GLUCOSAMI
NIDASE
(Thermococcus
kodakarensis) 		4 / 5 LEU A 380
TYR A 379
ILE A 160
GLY A 102
 None
GCS  A 801 (-4.2A)
None
GCS  A 801 (-3.4A)
 0.98A 6hd6A-5gsmA:
undetectable		 6hd6A-5gsmA:
7.01