SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gt2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX
(Escherichia
coli) 		5 / 10 LEU A  96
TRP A  19
TYR A 238
GLY A 287
GLY A 288
 None
 1.12A 3ls4H-5gt2A:
undetectable		 3ls4H-5gt2A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX
(Escherichia
coli) 		5 / 12 THR A 282
ASP A 276
HIS A 216
MET A 266
PHE A 268
 HEM  A 401 ( 3.6A)
None
HEM  A 401 (-3.5A)
HEM  A 401 (-3.6A)
None
 1.33A 3ondA-5gt2A:
undetectable		 3ondA-5gt2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX
(Escherichia
coli) 		4 / 5 ALA A 292
PRO A 293
TYR A 171
ALA A  74
 None
 1.39A 3twpD-5gt2A:
undetectable		 3twpD-5gt2A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX
(Escherichia
coli) 		5 / 12 ILE A 231
VAL A 220
LEU A 263
GLY A 145
ASP A 144
 HEM  A 401 ( 4.9A)
HEM  A 401 ( 4.6A)
HEM  A 401 (-4.5A)
HEM  A 401 (-3.3A)
HEM  A 401 (-4.0A)
 1.09A 3uq6B-5gt2A:
undetectable		 3uq6B-5gt2A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX
(Escherichia
coli) 		4 / 5 ASP A 221
THR A 218
LEU A 217
GLU A 205
 HEM  A 401 ( 3.9A)
None
HEM  A 401 ( 4.6A)
None
 1.23A 4a3pA-5gt2A:
undetectable		 4a3pA-5gt2A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX
(Escherichia
coli) 		4 / 6 LYS A 297
PHE A  60
VAL A 160
ASP A 166
 None
 1.24A 5hesA-5gt2A:
undetectable		 5hesA-5gt2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX
(Escherichia
coli) 		4 / 5 ILE A  99
PHE A  45
SER A 109
ALA A 114
 None
 1.21A 5msdA-5gt2A:
undetectable		 5msdA-5gt2A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX
(Escherichia
coli) 		3 / 3 GLY A 246
LEU A 139
HIS A 245
 None
 0.68A 5u63A-5gt2A:
undetectable		 5u63A-5gt2A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX
(Escherichia
coli) 		3 / 3 GLY A 246
LEU A 139
HIS A 245
 None
 0.62A 5u63B-5gt2A:
undetectable		 5u63B-5gt2A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_1
(-)		 5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX
(Escherichia
coli) 		5 / 12 ASP A 276
HIS A 179
HIS A 216
MET A 266
PHE A 268
 None
HEM  A 401 (-4.6A)
HEM  A 401 (-3.5A)
HEM  A 401 (-3.6A)
None
 1.47A 6f3mB-5gt2A:
undetectable		 6f3mB-5gt2A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_1
(-)		 5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX
(Escherichia
coli) 		5 / 12 ASP A 276
HIS A 179
HIS A 216
MET A 266
PHE A 268
 None
HEM  A 401 (-4.6A)
HEM  A 401 (-3.5A)
HEM  A 401 (-3.6A)
None
 1.47A 6f3mD-5gt2A:
undetectable		 6f3mD-5gt2A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 5gt2 PROBABLE
DEFERROCHELATASE/PER
OXIDASE YFEX
(Escherichia
coli) 		5 / 12 THR A 282
ASP A 276
HIS A 216
MET A 266
PHE A 268
 HEM  A 401 ( 3.6A)
None
HEM  A 401 (-3.5A)
HEM  A 401 (-3.6A)
None
 1.33A 6f3nB-5gt2A:
undetectable		 6f3nB-5gt2A:
19.70