SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gtj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 5gtj DUAL SPECIFICITY
PROTEIN PHOSPHATASE
26
(Homo
sapiens) 		5 / 12 ALA A  62
ASP A  63
VAL A 156
GLY A 155
VAL A  91
 None
None
PO4  A 301 (-3.9A)
PO4  A 301 (-3.8A)
None
 0.98A 1fb7A-5gtjA:
undetectable		 1fb7A-5gtjA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5gtj DUAL SPECIFICITY
PROTEIN PHOSPHATASE
26
(Homo
sapiens) 		5 / 10 LEU A 201
PHE A 130
THR A 161
ALA A 134
ALA A 133
 None
 1.22A 1wygA-5gtjA:
undetectable		 1wygA-5gtjA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 5gtj DUAL SPECIFICITY
PROTEIN PHOSPHATASE
26
(Homo
sapiens) 		5 / 11 ALA A  94
GLN A 131
SER A 159
LEU A 162
LEU A 169
 None
None
PO4  A 301 ( 4.1A)
None
None
 0.82A 2xn5A-5gtjA:
undetectable		 2xn5A-5gtjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 5gtj DUAL SPECIFICITY
PROTEIN PHOSPHATASE
26
(Homo
sapiens) 		4 / 6 ASN A  78
ALA A  77
HIS A 151
ASP A  73
 None
 1.30A 3aruA-5gtjA:
undetectable		 3aruA-5gtjA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5gtj DUAL SPECIFICITY
PROTEIN PHOSPHATASE
26
(Homo
sapiens) 		4 / 8 SER A 159
HIS A 151
ARG A 158
ASN A  78
 PO4  A 301 ( 4.1A)
None
PO4  A 301 (-4.0A)
None
 1.12A 3kp2A-5gtjA:
undetectable
3kp2B-5gtjA:
undetectable		 3kp2A-5gtjA:
20.11
3kp2B-5gtjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5gtj DUAL SPECIFICITY
PROTEIN PHOSPHATASE
26
(Homo
sapiens) 		5 / 12 LEU A 167
ILE A 137
VAL A 150
LEU A  69
ALA A 160
 None
 1.11A 4o1zB-5gtjA:
undetectable		 4o1zB-5gtjA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 5gtj DUAL SPECIFICITY
PROTEIN PHOSPHATASE
26
(Homo
sapiens) 		4 / 6 ARG A  80
LEU A  83
ARG A  85
ARG A  84
 None
 1.26A 5l6eA-5gtjA:
undetectable
5l6eB-5gtjA:
undetectable		 5l6eA-5gtjA:
20.94
5l6eB-5gtjA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5gtj DUAL SPECIFICITY
PROTEIN PHOSPHATASE
26
(Homo
sapiens) 		4 / 8 LEU A 167
GLU A  64
LEU A 141
ILE A 148
 None
 0.63A 5mzjA-5gtjA:
undetectable		 5mzjA-5gtjA:
16.36