SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gtm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 10 LEU A 214
ILE A 202
LEU A 179
ASP A 236
ILE A 206
 None
 1.09A 1yi4A-5gtmA:
undetectable		 1yi4A-5gtmA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 7 ALA A  74
ALA A  72
ARG A  60
PRO A 106
 None
 0.87A 2ql8A-5gtmA:
undetectable
2ql8B-5gtmA:
2.6		 2ql8A-5gtmA:
12.17
2ql8B-5gtmA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 11 LEU A 331
LEU A  90
ILE A 245
VAL A  75
ILE A 177
 None
 1.06A 2uxoB-5gtmA:
undetectable		 2uxoB-5gtmA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		3 / 3 PHE A 302
SER A 219
LEU A 251
 None
 0.62A 2w1bA-5gtmA:
2.5		 2w1bA-5gtmA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 6 LEU A  70
GLN A  66
LEU A  68
GLU A  65
 None
 1.05A 3h5gB-5gtmA:
undetectable
3h5gC-5gtmA:
undetectable		 3h5gB-5gtmA:
5.35
3h5gC-5gtmA:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 12 VAL A 217
VAL A 215
LEU A 214
SER A 213
GLY A 274
 None
 1.04A 3n8yB-5gtmA:
0.0		 3n8yB-5gtmA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 7 SER A 589
ASN A 421
GLU A 419
ILE A 418
 None
 0.97A 4d33B-5gtmA:
undetectable		 4d33B-5gtmA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 10 LEU A 111
LEU A 176
SER A  84
LEU A  87
LEU A 327
 None
 1.01A 4yiaA-5gtmA:
undetectable		 4yiaA-5gtmA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 11 LEU A 323
VAL A 320
LEU A 111
GLY A  92
LEU A  87
 None
 1.13A 4zbqA-5gtmA:
2.8		 4zbqA-5gtmA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		5 / 12 ASP A  57
THR A 175
PRO A 180
ILE A 198
VAL A  64
 None
 1.49A 5dlvB-5gtmA:
undetectable		 5dlvB-5gtmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 5 ILE A 243
GLY A 239
ILE A 212
LEU A 271
 None
 0.91A 5dzkd-5gtmA:
undetectable
5dzkk-5gtmA:
undetectable
5dzky-5gtmA:
undetectable		 5dzkd-5gtmA:
17.91
5dzkk-5gtmA:
16.72
5dzky-5gtmA:
0.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 6 GLU A  65
ARG A 208
ALA A  72
LEU A  70
 None
 1.12A 5phhA-5gtmA:
undetectable		 5phhA-5gtmA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		3 / 3 TYR A 451
ARG A 452
THR A 456
 None
 0.86A 5z84J-5gtmA:
undetectable		 5z84J-5gtmA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		4 / 8 LEU A 176
VAL A 216
LEU A 214
ILE A 245
 None
 0.74A 6cb4A-5gtmA:
undetectable		 6cb4A-5gtmA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens) 		3 / 3 ASP A 377
SER A 617
SER A 620
 None
 0.67A 6mxtA-5gtmA:
3.0		 6mxtA-5gtmA:
22.41