SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gtq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gtq LUCIFERIN
REGENERATING ENZYME
(Photinus
pyralis) 		3 / 3 VAL A 257
ALA A 258
HIS A  21
 None
 0.73A 1q23J-5gtqA:
undetectable		 1q23J-5gtqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5gtq LUCIFERIN
REGENERATING ENZYME
(Photinus
pyralis) 		4 / 5 MET A 125
ALA A 157
ILE A 158
ASP A 128
 None
None
MPD  A 405 ( 4.6A)
None
 1.12A 1upfC-5gtqA:
undetectable		 1upfC-5gtqA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5gtq LUCIFERIN
REGENERATING ENZYME
(Photinus
pyralis) 		4 / 7 VAL A  16
GLY A  17
THR A 270
ASP A 111
 None
None
None
MG  A 403 ( 4.6A)
 0.92A 2a1mA-5gtqA:
undetectable		 2a1mA-5gtqA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 5gtq LUCIFERIN
REGENERATING ENZYME
(Photinus
pyralis) 		4 / 5 ILE A 174
SER A 176
PRO A 211
PHE A 227
 None
MPD  A 405 ( 3.7A)
None
MPD  A 405 (-3.6A)
 1.38A 3bjwC-5gtqA:
undetectable		 3bjwC-5gtqA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5gtq LUCIFERIN
REGENERATING ENZYME
(Photinus
pyralis) 		4 / 4 LEU A 131
ALA A 157
VAL A 136
PRO A 135
 None
 1.23A 3gv1B-5gtqA:
undetectable		 3gv1B-5gtqA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5gtq LUCIFERIN
REGENERATING ENZYME
(Photinus
pyralis) 		5 / 12 PHE A  60
LEU A 308
LEU A 143
ILE A  97
PHE A  71
 None
None
None
None
GOL  A 406 (-3.5A)
 1.23A 3ko0M-5gtqA:
undetectable
3ko0N-5gtqA:
undetectable
3ko0O-5gtqA:
undetectable
3ko0P-5gtqA:
undetectable		 3ko0M-5gtqA:
15.58
3ko0N-5gtqA:
15.58
3ko0O-5gtqA:
15.58
3ko0P-5gtqA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5gtq LUCIFERIN
REGENERATING ENZYME
(Photinus
pyralis) 		5 / 12 GLY A 303
ALA A 302
ASP A 115
ALA A 114
ASP A  23
 None
None
None
None
GOL  A 406 ( 3.9A)
 1.14A 3nmuA-5gtqA:
undetectable
3nmuF-5gtqA:
undetectable		 3nmuA-5gtqA:
20.35
3nmuF-5gtqA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5gtq LUCIFERIN
REGENERATING ENZYME
(Photinus
pyralis) 		4 / 6 ASN A 160
TYR A 184
GLU A 153
ILE A 156
 MG  A 403 ( 2.6A)
None
None
None
 1.17A 3q5sA-5gtqA:
undetectable		 3q5sA-5gtqA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gtq LUCIFERIN
REGENERATING ENZYME
(Photinus
pyralis) 		5 / 10 THR A 122
LEU A  75
VAL A  54
PHE A  39
VAL A  73
 None
None
None
HG  A 402 (-4.2A)
None
 1.50A 3u9fE-5gtqA:
undetectable		 3u9fE-5gtqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gtq LUCIFERIN
REGENERATING ENZYME
(Photinus
pyralis) 		5 / 10 THR A 122
LEU A  75
VAL A  54
PHE A  39
VAL A  73
 None
None
None
HG  A 402 (-4.2A)
None
 1.47A 3u9fI-5gtqA:
undetectable		 3u9fI-5gtqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gtq LUCIFERIN
REGENERATING ENZYME
(Photinus
pyralis) 		5 / 9 THR A 122
LEU A  75
VAL A  54
PHE A  39
VAL A  73
 None
None
None
HG  A 402 (-4.2A)
None
 1.46A 3u9fP-5gtqA:
undetectable		 3u9fP-5gtqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gtq LUCIFERIN
REGENERATING ENZYME
(Photinus
pyralis) 		5 / 12 THR A 122
LEU A  75
VAL A  54
PHE A  39
VAL A  73
 None
None
None
HG  A 402 (-4.2A)
None
 1.44A 3u9fP-5gtqA:
undetectable
3u9fS-5gtqA:
undetectable		 3u9fP-5gtqA:
21.00
3u9fS-5gtqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 5gtq LUCIFERIN
REGENERATING ENZYME
(Photinus
pyralis) 		5 / 12 PHE A 227
GLY A 273
ALA A 272
ILE A 249
THR A 255
 MPD  A 405 (-3.6A)
None
None
None
None
 0.92A 4xdrA-5gtqA:
undetectable		 4xdrA-5gtqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4J_A_LNRA412_1
(ENDOTHIAPEPSIN)		 5gtq LUCIFERIN
REGENERATING ENZYME
(Photinus
pyralis) 		5 / 9 SER A  74
SER A  59
PHE A  60
ASP A 111
LEU A 120
 None
None
None
MG  A 403 ( 4.6A)
None
 1.34A 4y4jA-5gtqA:
undetectable		 4y4jA-5gtqA:
22.84