SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gu6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		4 / 8 GLU A  93
GLU A 226
GLU A 230
GLU A 229
 None
 1.04A 1knyA-5gu6A:
undetectable
1knyB-5gu6A:
undetectable		 1knyA-5gu6A:
21.15
1knyB-5gu6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		4 / 5 LEU A 235
GLN A 257
THR A 264
HIS A 323
 None
 1.33A 2zj0B-5gu6A:
undetectable		 2zj0B-5gu6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		4 / 5 LEU A 235
GLN A 257
THR A 264
HIS A 323
 None
 1.30A 2zj0C-5gu6A:
undetectable		 2zj0C-5gu6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		4 / 7 GLU A 229
ARG A 372
ARG A  95
GLU A  93
 None
 1.24A 2zt7A-5gu6A:
2.5		 2zt7A-5gu6A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		5 / 11 ILE A 249
LEU A 237
ILE A 292
ILE A 311
PHE A 306
 None
 1.15A 3b2rB-5gu6A:
undetectable		 3b2rB-5gu6A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		5 / 12 ILE A  69
LEU A   5
LEU A  14
ASN A  23
VAL A  22
 None
 1.23A 3dcjA-5gu6A:
undetectable
3dcjB-5gu6A:
undetectable		 3dcjA-5gu6A:
17.85
3dcjB-5gu6A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		5 / 10 LEU A 258
THR A 264
HIS A 323
ILE A 294
ILE A 265
 None
 1.17A 3kcxA-5gu6A:
undetectable		 3kcxA-5gu6A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		3 / 3 ARG A  30
PHE A  31
PRO A  79
 None
 0.87A 3zoaB-5gu6A:
undetectable		 3zoaB-5gu6A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		4 / 5 PHE A 234
ILE A 219
GLY A 224
THR A 228
 None
 0.90A 4ejjC-5gu6A:
undetectable		 4ejjC-5gu6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		4 / 5 TYR A 368
LYS A  77
LEU A  81
GLU A  93
 None
 1.34A 4olaA-5gu6A:
2.1		 4olaA-5gu6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		4 / 6 TYR A 368
LYS A  77
LEU A  81
GLU A  93
 None
 1.21A 4z4cA-5gu6A:
undetectable		 4z4cA-5gu6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		4 / 5 TYR A 368
LYS A  77
LEU A  81
GLU A  93
 None
 1.25A 4z4dA-5gu6A:
undetectable		 4z4dA-5gu6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		4 / 5 TYR A 368
LYS A  77
LEU A  81
GLU A  93
 None
 1.29A 4z4hA-5gu6A:
1.9		 4z4hA-5gu6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		4 / 5 TYR A 368
LYS A  77
LEU A  81
GLU A  93
 None
 1.32A 5js1A-5gu6A:
undetectable		 5js1A-5gu6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		5 / 10 TYR A 182
ILE A 134
ILE A 181
ILE A 124
ILE A 118
 None
 1.04A 5murE-5gu6A:
undetectable		 5murE-5gu6A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		4 / 5 TYR A 368
LYS A  77
LEU A  81
GLU A  93
 None
 1.23A 6cbdA-5gu6A:
undetectable		 6cbdA-5gu6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens) 		4 / 7 ARG A 329
HIS A 328
GLU A 330
ASP A 336
 None
 1.37A 6mn4E-5gu6A:
undetectable		 6mn4E-5gu6A:
20.92