SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5guf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		4 / 4 ALA A  77
VAL A  74
ALA A  86
HIS A  88
 None
 1.03A 1q23A-5gufA:
undetectable		 1q23A-5gufA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		4 / 4 ALA A  77
VAL A  74
ALA A  86
HIS A  88
 None
 1.08A 1q23F-5gufA:
undetectable		 1q23F-5gufA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		4 / 4 ALA A  77
VAL A  74
ALA A  86
HIS A  88
 None
 1.00A 1q23K-5gufA:
undetectable		 1q23K-5gufA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		5 / 11 MET A  21
GLY A  95
VAL A 133
ILE A  26
ALA A  27
 None
 0.89A 2yy8A-5gufA:
undetectable
2yy8B-5gufA:
undetectable		 2yy8A-5gufA:
23.77
2yy8B-5gufA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		4 / 8 ALA A  72
ALA A  76
PRO A  23
ILE A  26
 None
 0.80A 3dtuC-5gufA:
1.0
3dtuD-5gufA:
undetectable		 3dtuC-5gufA:
16.25
3dtuD-5gufA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 SER A 104
ASP A 100
ASP A  41
 CTP  A 201 (-2.3A)
CTP  A 201 ( 3.4A)
None
 0.85A 3iv6A-5gufA:
undetectable		 3iv6A-5gufA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 SER A 104
ASP A 100
ASP A  41
 CTP  A 201 (-2.3A)
CTP  A 201 ( 3.4A)
None
 0.85A 3iv6C-5gufA:
undetectable		 3iv6C-5gufA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		5 / 12 ILE A  19
ALA A 152
PRO A  23
ALA A  24
ILE A  14
 None
 1.11A 3jayA-5gufA:
undetectable		 3jayA-5gufA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KD5_E_PPFE914_1
(DNA POLYMERASE)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		4 / 5 ASP A 100
LEU A 121
ARG A 108
ASP A 125
 CTP  A 201 ( 3.4A)
None
CTP  A 201 (-2.9A)
K  A 205 ( 3.8A)
 1.50A 3kd5E-5gufA:
1.5		 3kd5E-5gufA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		3 / 3 LYS A  57
ARG A 109
VAL A 106
 CTP  A 201 (-2.4A)
None
None
 0.68A 4x3uA-5gufA:
undetectable
4x3uB-5gufA:
undetectable		 4x3uA-5gufA:
20.35
4x3uB-5gufA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		4 / 5 ASP A 100
VAL A  40
ASP A  41
GLY A  54
 CTP  A 201 ( 3.4A)
None
None
None
 1.20A 4xp6A-5gufA:
0.1		 4xp6A-5gufA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		4 / 4 ALA A  24
ALA A  27
ALA A  96
ALA A 130
 None
 0.81A 6gtqA-5gufA:
undetectable
6gtqB-5gufA:
undetectable		 6gtqA-5gufA:
22.73
6gtqB-5gufA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5guf CDP-ARCHAEOL
SYNTHASE
(Aeropyrum
pernix) 		4 / 4 ALA A  96
ALA A 130
ALA A  24
ALA A  27
 None
 0.81A 6gtqA-5gufA:
undetectable
6gtqB-5gufA:
undetectable		 6gtqA-5gufA:
22.73
6gtqB-5gufA:
22.73