SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5guh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 5guh PIWI
(Bombyx
mori) 		5 / 10 GLY A 514
GLN A 863
ILE A 498
TYR A 506
GLY A 509
 None
 1.47A 1fohC-5guhA:
undetectable		 1fohC-5guhA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 5guh PIWI
(Bombyx
mori) 		5 / 10 GLY A 514
GLN A 863
ILE A 498
TYR A 506
GLY A 509
 None
 1.45A 1fohD-5guhA:
undetectable		 1fohD-5guhA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 5guh PIWI
(Bombyx
mori) 		3 / 3 GLU A 578
HIS A 573
ASP A 605
 None
 0.53A 1i9gA-5guhA:
undetectable		 1i9gA-5guhA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_1
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5guh PIWI
(Bombyx
mori) 		4 / 4 THR A 149
GLN A 492
GLU A 496
ASP A 658
 None
 1.30A 1nw3A-5guhA:
undetectable		 1nw3A-5guhA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 5guh PIWI
(Bombyx
mori) 		5 / 10 GLY A 514
GLN A 863
ILE A 498
TYR A 506
GLY A 509
 None
 1.46A 1pn0C-5guhA:
undetectable		 1pn0C-5guhA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 5guh PIWI
(Bombyx
mori) 		5 / 10 GLY A 514
GLN A 863
ILE A 498
TYR A 506
GLY A 509
 None
 1.45A 1pn0D-5guhA:
undetectable		 1pn0D-5guhA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 5guh PIWI
(Bombyx
mori) 		5 / 12 LEU A 596
LEU A 568
ILE A 552
ILE A 553
LEU A 530
 None
 0.95A 1qknA-5guhA:
undetectable		 1qknA-5guhA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5guh PIWI
(Bombyx
mori) 		5 / 12 ILE A 737
ILE A 776
ALA A 774
LEU A 853
ILE A 659
 None
 1.14A 1xzxX-5guhA:
undetectable		 1xzxX-5guhA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5guh PIWI
(Bombyx
mori) 		5 / 12 ILE A 308
THR A 306
LEU A 457
THR A 826
PHE A 787
 None
 1.21A 2qo5A-5guhA:
undetectable		 2qo5A-5guhA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 5guh PIWI
(Bombyx
mori) 		5 / 9 TRP A 288
VAL A 312
ILE A 287
GLY A 290
LYS A 292
 None
 1.38A 2xh9B-5guhA:
undetectable		 2xh9B-5guhA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5guh PIWI
(Bombyx
mori) 		5 / 12 ILE A 846
ILE A 776
PHE A 815
ILE A 659
VAL A 869
 None
 1.03A 2ygoA-5guhA:
undetectable		 2ygoA-5guhA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5guh PIWI
(Bombyx
mori) 		5 / 10 TYR A 738
ILE A 777
VAL A 778
SER A 779
ILE A 782
 None
 1.42A 3uprA-5guhA:
undetectable		 3uprA-5guhA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5guh PIWI
(Bombyx
mori) 		5 / 10 TYR A 738
ILE A 777
VAL A 778
SER A 779
ILE A 782
 None
 1.37A 3uprC-5guhA:
undetectable		 3uprC-5guhA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 5guh PIWI
(Bombyx
mori) 		4 / 5 LEU A 599
ARG A 606
PRO A 576
ALA A 609
 U  B   1 ( 4.8A)
None
None
None
 1.34A 3vm4A-5guhA:
undetectable		 3vm4A-5guhA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 5guh PIWI
(Bombyx
mori) 		5 / 7 ASN A 296
LEU A 302
GLY A 243
TYR A 247
SER A 241
 None
 1.31A 4cp3A-5guhA:
undetectable
4cp3B-5guhA:
undetectable		 4cp3A-5guhA:
10.44
4cp3B-5guhA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 5guh PIWI
(Bombyx
mori) 		3 / 3 CYH A 583
ASN A 581
LYS A 613
 None
 1.12A 4k50A-5guhA:
undetectable		 4k50A-5guhA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5guh PIWI
(Bombyx
mori) 		4 / 4 THR A 537
ARG A 542
GLU A 546
VAL A 570
 None
 1.45A 4odoC-5guhA:
0.8		 4odoC-5guhA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5guh PIWI
(Bombyx
mori) 		5 / 9 ALA A 643
THR A 640
ALA A 639
GLY A 560
GLY A 557
 None
 1.11A 4qwuK-5guhA:
undetectable
4qwuL-5guhA:
undetectable		 4qwuK-5guhA:
12.62
4qwuL-5guhA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5guh PIWI
(Bombyx
mori) 		5 / 9 ALA A 643
THR A 640
ALA A 639
GLY A 560
GLY A 557
 None
 1.11A 4qwuY-5guhA:
undetectable
4qwuZ-5guhA:
undetectable		 4qwuY-5guhA:
12.62
4qwuZ-5guhA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 5guh PIWI
(Bombyx
mori) 		4 / 6 LEU A 304
LEU A 479
ILE A 248
PHE A 251
 None
 1.07A 4y4dA-5guhA:
undetectable		 4y4dA-5guhA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5guh PIWI
(Bombyx
mori) 		3 / 3 GLU A 578
HIS A 573
ASP A 605
 None
 0.60A 5c0oG-5guhA:
2.0		 5c0oG-5guhA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5guh PIWI
(Bombyx
mori) 		5 / 10 TYR A 738
ILE A 777
VAL A 778
SER A 779
ILE A 782
 None
 1.40A 5u98A-5guhA:
undetectable		 5u98A-5guhA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5guh PIWI
(Bombyx
mori) 		4 / 8 THR A 354
THR A 348
TYR A 350
PRO A 405
 None
 1.14A 5x2sI-5guhA:
undetectable
5x2sJ-5guhA:
undetectable
5x2sK-5guhA:
undetectable		 5x2sI-5guhA:
9.13
5x2sJ-5guhA:
10.64
5x2sK-5guhA:
9.13