SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gui'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 197
ARG A 228
ARG A 207
LEU A 183
GLU A 186
 PO4  A 301 (-3.6A)
None
None
None
None
 1.24A 1mj2C-5guiA:
undetectable
1mj2D-5guiA:
undetectable		 1mj2C-5guiA:
24.50
1mj2D-5guiA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 197
ARG A 228
ARG A 207
LEU A 183
GLU A 186
 PO4  A 301 (-3.6A)
None
None
None
None
 1.26A 1mjoC-5guiA:
undetectable
1mjoD-5guiA:
undetectable		 1mjoC-5guiA:
24.50
1mjoD-5guiA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 132
GLY A 134
ILE A 106
SER A 198
LEU A 201
 None
None
None
PO4  A 301 (-2.5A)
None
 1.01A 1v2xA-5guiA:
undetectable		 1v2xA-5guiA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 LEU A 220
PRO A 224
ALA A 222
ILE A 147
 None
 1.05A 2aofB-5guiA:
undetectable		 2aofB-5guiA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 217
GLY A 211
VAL A 156
GLY A 122
VAL A 216
 None
PO4  A 304 (-2.9A)
None
PO4  A 302 (-3.1A)
None
 1.05A 3gguA-5guiA:
undetectable		 3gguA-5guiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 LEU A 217
GLY A 211
VAL A 156
GLY A 122
VAL A 216
 None
PO4  A 304 (-2.9A)
None
PO4  A 302 (-3.1A)
None
 1.03A 3nu9B-5guiA:
undetectable		 3nu9B-5guiA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 PHE A  95
PHE A  98
ALA A 177
THR A 174
 None
None
PO4  A 302 ( 4.5A)
PO4  A 302 (-3.0A)
 1.12A 3t3sB-5guiA:
undetectable		 3t3sB-5guiA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 HIS A 118
LEU A 149
LEU A 127
ASP A 151
 None
 1.09A 4aqlA-5guiA:
undetectable		 4aqlA-5guiA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A 147
LEU A 128
LEU A 142
ALA A 213
LEU A 220
 None
 0.94A 4m11B-5guiA:
undetectable		 4m11B-5guiA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 202
GLU A 100
GLY A 136
ALA A 139
ILE A 131
 None
PO4  A 305 ( 4.4A)
PO4  A 301 (-3.3A)
None
None
 1.21A 4xe5A-5guiA:
undetectable		 4xe5A-5guiA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 ILE A 131
ALA A 152
LEU A 127
GLU A 112
VAL A 156
 None
 1.35A 5hw4B-5guiA:
undetectable		 5hw4B-5guiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 LEU A 128
ALA A 213
LEU A 217
LEU A 220
LEU A 130
 None
 1.32A 5hyrA-5guiA:
undetectable		 5hyrA-5guiA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 LEU A 181
ARG A  97
ILE A 196
PHE A  98
 None
 1.22A 5kirB-5guiA:
undetectable		 5kirB-5guiA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 132
GLY A 134
ILE A 106
SER A 198
LEU A 201
 None
None
None
PO4  A 301 (-2.5A)
None
 1.02A 5l0zA-5guiA:
undetectable		 5l0zA-5guiA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 GLY A 132
GLY A 134
ILE A 106
SER A 198
LEU A 201
 None
None
None
PO4  A 301 (-2.5A)
None
 0.92A 5l0zB-5guiA:
undetectable		 5l0zB-5guiA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 VAL A 231
LEU A 181
ALA A 138
THR A 123
LEU A 217
 None
None
None
PO4  A 302 (-3.0A)
None
 1.37A 5mm4B-5guiA:
undetectable		 5mm4B-5guiA:
18.30