SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5guj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		5 / 10 VAL A 297
LEU A 292
TYR A 311
VAL A 335
GLU A 326
 None
 1.27A 1fdwA-5gujA:
2.7		 1fdwA-5gujA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		5 / 12 LEU A 174
ASP A 201
ILE A 191
ARG A 202
TYR A 128
 None
 1.29A 1l7fA-5gujA:
undetectable		 1l7fA-5gujA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7G_A_BCZA801_0
(NEURAMINIDASE)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		5 / 12 LEU A 174
ASP A 201
ILE A 191
ARG A 202
TYR A 128
 None
 1.28A 1l7gA-5gujA:
undetectable		 1l7gA-5gujA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		4 / 7 VAL A 207
ILE A 160
SER A 147
TYR A 144
 None
 0.93A 3pglA-5gujA:
undetectable		 3pglA-5gujA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		4 / 6 GLU A 114
GLY A 113
LEU A 241
GLU A 119
 None
 0.83A 3w9tB-5gujA:
undetectable		 3w9tB-5gujA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		4 / 6 GLU A 114
GLY A 113
LEU A 241
GLU A 119
 None
 0.84A 3w9tE-5gujA:
undetectable		 3w9tE-5gujA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		4 / 6 GLU A 114
GLY A 113
LEU A 241
GLU A 119
 None
 0.84A 3w9tF-5gujA:
undetectable		 3w9tF-5gujA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		5 / 10 VAL A 219
ALA A 187
SER A 222
VAL A 218
THR A 239
 None
 1.50A 4eilD-5gujA:
undetectable		 4eilD-5gujA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		5 / 10 VAL A 219
ALA A 187
SER A 222
VAL A 218
THR A 239
 None
 1.45A 4kyaC-5gujA:
undetectable		 4kyaC-5gujA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		5 / 11 VAL A 219
ALA A 187
SER A 222
VAL A 218
THR A 239
 None
 1.45A 4kyaE-5gujA:
undetectable		 4kyaE-5gujA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		5 / 11 VAL A 219
ALA A 187
SER A 222
VAL A 218
THR A 239
 None
 1.44A 4kyaG-5gujA:
undetectable		 4kyaG-5gujA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		4 / 8 GLY A 198
THR A 171
TYR A 199
ARG A 192
 None
 1.02A 4m5mA-5gujA:
undetectable		 4m5mA-5gujA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		4 / 6 ASP A 345
ASP A 272
ALA A 286
ASP A 312
 None
 1.13A 4mdaA-5gujA:
undetectable		 4mdaA-5gujA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		4 / 6 ASP A 345
ASP A 272
ALA A 286
ASP A 312
 None
 1.11A 4mdbA-5gujA:
undetectable		 4mdbA-5gujA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		5 / 12 LEU A 174
ASP A 201
ILE A 191
ARG A 202
TYR A 128
 None
 1.29A 4mwvA-5gujA:
undetectable		 4mwvA-5gujA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		5 / 11 LEU A 292
GLU A 326
LEU A 328
LEU A 309
LEU A 266
 None
 1.13A 4wg0G-5gujA:
undetectable
4wg0H-5gujA:
undetectable
4wg0I-5gujA:
undetectable		 4wg0G-5gujA:
3.51
4wg0H-5gujA:
3.51
4wg0I-5gujA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		5 / 11 LEU A 292
GLU A 326
LEU A 328
LEU A 309
LEU A 266
 None
 1.08A 4wg0K-5gujA:
undetectable
4wg0L-5gujA:
undetectable
4wg0M-5gujA:
undetectable		 4wg0K-5gujA:
3.51
4wg0L-5gujA:
3.51
4wg0M-5gujA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		5 / 10 GLY A 149
ALA A 271
ASP A 272
SER A 275
ALA A 276
 None
 0.93A 4wnuD-5gujA:
undetectable		 4wnuD-5gujA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		3 / 3 VAL A 297
GLN A 329
CYH A 333
 None
 0.61A 5icxA-5gujA:
undetectable
5icxE-5gujA:
undetectable		 5icxA-5gujA:
22.62
5icxE-5gujA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5guj DNA PRIMASE
(Bacillus
subtilis) 		3 / 3 VAL A 297
GLN A 329
CYH A 333
 None
 0.65A 5icxC-5gujA:
undetectable
5icxF-5gujA:
undetectable		 5icxC-5gujA:
22.62
5icxF-5gujA:
5.69