SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 8 PHE A1567
TYR A1565
GLY A1152
GLY A1153
None
None
SAH  A1701 (-3.8A)
SAH  A1701 (-3.3A)
0.53A 1ekjE-5gutA:
undetectable
1ekjF-5gutA:
undetectable
1ekjE-5gutA:
13.50
1ekjF-5gutA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 6 HIS A1509
LEU A1515
LEU A1502
PRO A1503
None
1.11A 1hz4A-5gutA:
undetectable
1hz4A-5gutA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 5 LEU A1458
VAL A1478
CYH A1479
CYH A1481
None
None
ZN  A1703 (-2.3A)
ZN  A1703 (-2.3A)
1.00A 1mz9D-5gutA:
undetectable
1mz9D-5gutA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 ASP A1193
CYH A1194
PRO A1228
PHE A1148
GLY A1150
SAH  A1701 (-3.7A)
SAH  A1701 (-3.7A)
SAH  A1701 ( 4.5A)
SAH  A1701 (-4.8A)
SAH  A1701 (-3.5A)
0.67A 1nw5A-5gutA:
1.8
1nw5A-5gutA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 7 VAL A1282
VAL A1348
TYR A 877
CYH A1229
None
1.27A 1t46A-5gutA:
undetectable
1t46A-5gutA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 THR A1064
CYH A1063
SER A1079
TYR A1078
VAL A1065
None
1.44A 1z9hA-5gutA:
undetectable
1z9hA-5gutA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 THR A1064
CYH A1063
SER A1079
TYR A1078
VAL A1065
None
1.45A 1z9hB-5gutA:
undetectable
1z9hB-5gutA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 PHE A1148
GLY A1150
GLY A1152
ASP A1193
PRO A1228
SAH  A1701 (-4.8A)
SAH  A1701 (-3.5A)
SAH  A1701 (-3.8A)
SAH  A1701 (-3.7A)
SAH  A1701 ( 4.5A)
0.97A 2dpmA-5gutA:
6.9
2dpmA-5gutA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
6 / 12 PHE A1148
GLY A1150
GLY A1153
ASP A1193
LEU A1250
TYR A1565
SAH  A1701 (-4.8A)
SAH  A1701 (-3.5A)
SAH  A1701 (-3.3A)
SAH  A1701 (-3.7A)
SAH  A1701 (-4.6A)
None
1.47A 2hmyB-5gutA:
26.2
2hmyB-5gutA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
7 / 12 PHE A1148
GLY A1150
GLY A1153
ASP A1193
PRO A1228
LEU A1250
VAL A1582
SAH  A1701 (-4.8A)
SAH  A1701 (-3.5A)
SAH  A1701 (-3.3A)
SAH  A1701 (-3.7A)
SAH  A1701 ( 4.5A)
SAH  A1701 (-4.6A)
SAH  A1701 (-4.0A)
0.98A 2hmyB-5gutA:
26.2
2hmyB-5gutA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 LYS A 885
TYR A 839
PRO A 883
None
1.44A 2j9cC-5gutA:
undetectable
2j9cC-5gutA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 ALA A1581
GLN A1559
LEU A1586
THR A1166
PHE A1180
SAH  A1701 (-3.5A)
None
None
None
None
1.43A 2oaxC-5gutA:
undetectable
2oaxC-5gutA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 ALA A1581
GLN A1559
LEU A1586
THR A1166
PHE A1180
SAH  A1701 (-3.5A)
None
None
None
None
1.35A 2oaxF-5gutA:
undetectable
2oaxF-5gutA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 6 TYR A1034
PRO A 994
ILE A 997
ASN A1029
None
1.35A 2wekB-5gutA:
5.4
2wekB-5gutA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 VAL A1552
ILE A1416
ARG A1566
ALA A1179
PHE A1568
None
1.31A 3apwB-5gutA:
undetectable
3apwB-5gutA:
12.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
12 / 12 PHE A1148
GLY A1150
GLY A1153
LEU A1154
MET A1172
TRP A1173
CYH A1194
PRO A1228
LEU A1250
ASN A1580
ALA A1581
VAL A1582
SAH  A1701 (-4.8A)
SAH  A1701 (-3.5A)
SAH  A1701 (-3.3A)
SAH  A1701 (-4.3A)
SAH  A1701 (-3.8A)
None
SAH  A1701 (-3.7A)
SAH  A1701 ( 4.5A)
SAH  A1701 (-4.6A)
SAH  A1701 (-3.9A)
SAH  A1701 (-3.5A)
SAH  A1701 (-4.0A)
0.38A 3av6A-5gutA:
39.3
3av6A-5gutA:
99.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
7 / 12 PHE A1148
GLY A1152
LEU A1154
PRO A1228
LEU A1250
ASN A1580
ALA A1581
SAH  A1701 (-4.8A)
SAH  A1701 (-3.8A)
SAH  A1701 (-4.3A)
SAH  A1701 ( 4.5A)
SAH  A1701 (-4.6A)
SAH  A1701 (-3.9A)
SAH  A1701 (-3.5A)
1.08A 3av6A-5gutA:
39.3
3av6A-5gutA:
99.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 5 VAL A1348
VAL A1347
GLN A1343
PHE A1274
None
1.39A 3bjwH-5gutA:
undetectable
3bjwH-5gutA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 CYH A 823
CYH A 897
HIS A 798
ZN  A1702 (-2.2A)
ZN  A1702 (-2.2A)
None
0.87A 3dtuB-5gutA:
undetectable
3dtuB-5gutA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
6 / 12 PHE A1148
GLY A1153
ASP A1193
PRO A1228
LEU A1250
ASN A1580
SAH  A1701 (-4.8A)
SAH  A1701 (-3.3A)
SAH  A1701 (-3.7A)
SAH  A1701 ( 4.5A)
SAH  A1701 (-4.6A)
SAH  A1701 (-3.9A)
0.87A 3eeoA-5gutA:
undetectable
3eeoA-5gutA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 10 ALA A 802
SER A 767
ILE A 769
TYR A 867
THR A 804
None
1.27A 3qgtA-5gutA:
undetectable
3qgtA-5gutA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 10 ALA A 802
SER A 767
ILE A 769
TYR A 867
THR A 804
None
1.18A 3qgtB-5gutA:
undetectable
3qgtB-5gutA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 8 LEU A 819
VAL A 837
TYR A 839
LEU A 898
None
1.00A 3v81C-5gutA:
undetectable
3v81C-5gutA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 6 GLY A1150
GLU A1171
ASP A1193
ASP A1146
SAH  A1701 (-3.5A)
SAH  A1701 (-2.7A)
SAH  A1701 (-3.7A)
None
0.84A 3vywC-5gutA:
8.1
3vywC-5gutA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 7 ALA A1581
PHE A1561
ALA A1556
THR A1528
SAH  A1701 (-3.5A)
None
None
None
0.93A 4du2A-5gutA:
undetectable
4du2A-5gutA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 7 ALA A1581
PHE A1561
ALA A1556
THR A1528
SAH  A1701 (-3.5A)
None
None
None
0.89A 4du2B-5gutA:
undetectable
4du2B-5gutA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 TRP A1439
ALA A1513
GLY A1539
GLY A1517
LEU A1542
None
1.04A 4lg1A-5gutA:
8.9
4lg1A-5gutA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 TRP A1439
ALA A1513
GLY A1539
GLY A1517
LEU A1542
None
1.05A 4lg1B-5gutA:
8.8
4lg1B-5gutA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 TRP A1439
ALA A1513
GLY A1539
GLY A1517
LEU A1542
None
1.03A 4lg1C-5gutA:
7.1
4lg1C-5gutA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 LEU A1268
MET A1172
GLU A1171
ILE A1170
ALA A1169
None
SAH  A1701 (-3.8A)
SAH  A1701 (-2.7A)
None
None
0.98A 4ltwA-5gutA:
undetectable
4ltwA-5gutA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 4 ILE A1416
VAL A1550
VAL A1552
ARG A1574
None
1.04A 4m6tA-5gutA:
undetectable
4m6tA-5gutA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 4 ILE A1571
VAL A1550
VAL A1552
ARG A1574
None
1.03A 4m6tA-5gutA:
undetectable
4m6tA-5gutA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 GLY A1305
GLN A1306
LEU A1586
VAL A1301
THR A1527
None
None
None
None
SO4  A1704 (-4.0A)
1.42A 4okxA-5gutA:
undetectable
4okxA-5gutA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 ARG A1440
ASP A1438
TRP A1439
None
1.02A 4xdqA-5gutA:
undetectable
4xdqA-5gutA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 7 SER A1094
TYR A1092
SER A1048
GLU A1050
None
1.09A 4xzkA-5gutA:
undetectable
4xzkA-5gutA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 GLY A1300
THR A1298
ASN A1356
ILE A1318
ILE A1590
None
1.05A 4zvmA-5gutA:
3.5
4zvmB-5gutA:
4.3
4zvmA-5gutA:
14.40
4zvmB-5gutA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 11 PRO A 883
LEU A 819
VAL A 837
TYR A 839
LEU A 898
None
1.28A 5hbmA-5gutA:
undetectable
5hbmA-5gutA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 ASP A1193
PRO A1228
PHE A1148
GLY A1150
GLU A1171
SAH  A1701 (-3.7A)
SAH  A1701 ( 4.5A)
SAH  A1701 (-4.8A)
SAH  A1701 (-3.5A)
SAH  A1701 (-2.7A)
0.60A 5hfjA-5gutA:
2.2
5hfjA-5gutA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 ASP A1193
PRO A1228
PHE A1148
GLY A1150
GLU A1171
SAH  A1701 (-3.7A)
SAH  A1701 ( 4.5A)
SAH  A1701 (-4.8A)
SAH  A1701 (-3.5A)
SAH  A1701 (-2.7A)
0.54A 5hfjD-5gutA:
2.3
5hfjD-5gutA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 ASP A1193
PRO A1228
PHE A1148
GLY A1150
GLU A1171
SAH  A1701 (-3.7A)
SAH  A1701 ( 4.5A)
SAH  A1701 (-4.8A)
SAH  A1701 (-3.5A)
SAH  A1701 (-2.7A)
0.57A 5hfjF-5gutA:
6.5
5hfjF-5gutA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 11 PHE A1148
GLY A1150
GLU A1171
ASP A1193
PRO A1228
SAH  A1701 (-4.8A)
SAH  A1701 (-3.5A)
SAH  A1701 (-2.7A)
SAH  A1701 (-3.7A)
SAH  A1701 ( 4.5A)
0.63A 5hjiA-5gutA:
4.3
5hjiA-5gutA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 ILE A1317
PHE A1266
ALA A1320
SER A1164
ILE A1163
None
1.44A 5iwuA-5gutA:
undetectable
5iwuA-5gutA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 4 GLU A1593
PRO A1328
ILE A1594
LEU A1596
None
1.30A 5m45A-5gutA:
undetectable
5m45A-5gutA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 4 GLU A1593
PRO A1328
ILE A1594
LEU A1596
None
1.27A 5m45D-5gutA:
undetectable
5m45D-5gutA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 4 GLU A1593
PRO A1328
ILE A1594
LEU A1596
None
1.28A 5m45G-5gutA:
undetectable
5m45G-5gutA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 4 GLU A1593
PRO A1328
ILE A1594
LEU A1596
None
1.27A 5m45J-5gutA:
undetectable
5m45J-5gutA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 ASP A1070
PHE A1088
ARG A 999
None
1.10A 5yw0A-5gutA:
undetectable
5yw0A-5gutA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 HIS A1415
ARG A1548
ILE A1380
None
0.77A 6fgdA-5gutA:
3.0
6fgdA-5gutA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 5 GLY A1579
THR A1528
HIS A1575
SER A1551
None
1.06A 6jmjA-5gutA:
2.2
6jmjA-5gutA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 6 GLY A1579
THR A1528
HIS A1575
SER A1551
None
1.07A 6jogA-5gutA:
3.0
6jogA-5gutA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
6 / 12 PHE A1148
GLY A1150
GLY A1153
ASP A1193
ASN A1580
VAL A1582
SAH  A1701 (-4.8A)
SAH  A1701 (-3.5A)
SAH  A1701 (-3.3A)
SAH  A1701 (-3.7A)
SAH  A1701 (-3.9A)
SAH  A1701 (-4.0A)
0.90A 6mhtA-5gutA:
24.7
6mhtA-5gutA:
17.67