SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5guw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 5guw NITRIC OXIDE
REDUCTASE SUBUNIT C
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 126
VAL A  49
TRP A 131
 None
 0.98A 1gmkC-5guwA:
undetectable
1gmkD-5guwA:
undetectable		 1gmkC-5guwA:
8.51
1gmkD-5guwA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 5guw NITRIC OXIDE
REDUCTASE SUBUNIT C
(Pseudomonas
aeruginosa) 		3 / 4 VAL A  49
TRP A  56
TRP A 131
 None
 1.14A 1gmkC-5guwA:
undetectable
1gmkD-5guwA:
undetectable		 1gmkC-5guwA:
8.51
1gmkD-5guwA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5guw NITRIC OXIDE
REDUCTASE SUBUNIT C
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  95
ALA A 126
LYS A 130
LEU A 129
VAL A  55
 None
 1.06A 1sa1A-5guwA:
undetectable
1sa1B-5guwA:
undetectable		 1sa1A-5guwA:
15.78
1sa1B-5guwA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5guw NITRIC OXIDE
REDUCTASE SUBUNIT C
(Pseudomonas
aeruginosa) 		4 / 6 GLN A  96
PHE A  94
PHE A  91
LEU A 129
 None
 1.17A 3ablP-5guwA:
undetectable
3ablW-5guwA:
undetectable		 3ablP-5guwA:
18.01
3ablW-5guwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ATT_A_ACTA1209_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5guw NITRIC OXIDE
REDUCTASE SUBUNIT C
(Pseudomonas
aeruginosa) 		4 / 4 ASP A 124
ARG A  51
ASP A 123
GLU A 127
 None
 1.31A 3attA-5guwA:
undetectable		 3attA-5guwA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 5guw NITRIC OXIDE
REDUCTASE SUBUNIT C
(Pseudomonas
aeruginosa) 		3 / 3 VAL A  81
GLY A  83
LYS A 144
 HEC  A 201 (-4.7A)
None
None
 0.75A 4k50I-5guwA:
undetectable		 4k50I-5guwA:
15.79