SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 TRP A 238
ARG A 287
THR A 237
 None
 1.00A 1df7A-5gvaA:
undetectable		 1df7A-5gvaA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 PHE A 144
LEU A 151
ALA A  97
LEU A 202
LEU A 192
 None
 1.00A 1rlbF-5gvaA:
undetectable		 1rlbF-5gvaA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 VAL A 139
ALA A  97
ILE A  76
ILE A 120
LEU A 151
 None
 1.13A 3hbbA-5gvaA:
undetectable		 3hbbA-5gvaA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 THR A  13
THR A  17
GLY A  32
ARG A  38
ASP A 292
 None
 1.50A 3t8nD-5gvaA:
undetectable
3t8nF-5gvaA:
undetectable		 3t8nD-5gvaA:
17.70
3t8nF-5gvaA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 VAL A 139
ALA A  97
SER A 143
LEU A 151
VAL A 118
 None
 1.27A 4eilA-5gvaA:
undetectable		 4eilA-5gvaA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 VAL A 139
ALA A  97
SER A 143
LEU A 151
VAL A 118
 None
 1.32A 4eilE-5gvaA:
undetectable		 4eilE-5gvaA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 141
ASN A  98
CYH A 180
GLY A 158
 None
 0.90A 4fo4A-5gvaA:
undetectable		 4fo4A-5gvaA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 VAL A 139
ALA A  97
SER A 143
LEU A 151
VAL A 118
 None
 1.27A 4kyaA-5gvaA:
undetectable		 4kyaA-5gvaA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 VAL A 139
ALA A  97
SER A 143
LEU A 151
VAL A 118
 None
 1.26A 4kyaC-5gvaA:
undetectable		 4kyaC-5gvaA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 VAL A 139
ALA A  97
SER A 143
LEU A 151
VAL A 118
 None
 1.24A 4kyaE-5gvaA:
undetectable		 4kyaE-5gvaA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 VAL A 139
ALA A  97
SER A 143
LEU A 151
VAL A 118
 None
 1.27A 4kyaG-5gvaA:
undetectable		 4kyaG-5gvaA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 12 GLY A 298
HIS A 270
ASP A 292
HIS A  12
ASN A 296
LEU A  43
 None
 1.43A 4pooA-5gvaA:
undetectable		 4pooA-5gvaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A  93
ILE A  76
GLY A 112
LEU A 151
THR A 169
 None
 1.22A 4zdyA-5gvaA:
undetectable		 4zdyA-5gvaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A  93
ILE A  76
GLY A 112
LEU A 151
THR A 169
 None
 1.11A 4ze2A-5gvaA:
undetectable		 4ze2A-5gvaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 200
TRP A 194
SER A 198
 None
 1.33A 5nwwA-5gvaA:
undetectable		 5nwwA-5gvaA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A  93
ILE A  76
GLY A 112
LEU A 151
THR A 169
 None
 1.06A 6e8qA-5gvaA:
undetectable		 6e8qA-5gvaA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ILE A 109
ALA A  70
VAL A  71
ASP A 115
 None
 1.05A 6hu9a-5gvaA:
undetectable
6hu9e-5gvaA:
undetectable		 6hu9a-5gvaA:
19.00
6hu9e-5gvaA:
16.42