SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gvb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 787
ALA A 785
LEU A 769
MET A 725
 None
 1.05A 2oaxA-5gvbA:
undetectable		 2oaxA-5gvbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 THR A 637
PHE A 632
GLN A 582
LEU A 603
 None
 1.07A 3bgdA-5gvbA:
undetectable		 3bgdA-5gvbA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 604
LEU A 554
GLY A 616
HIS A 615
LEU A 614
 None
 1.32A 3hm1B-5gvbA:
undetectable		 3hm1B-5gvbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 604
LEU A 569
GLY A 616
HIS A 615
LEU A 614
 None
 1.31A 3hm1B-5gvbA:
undetectable		 3hm1B-5gvbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 PHE A 584
TYR A 587
LEU A 540
 None
 0.76A 3keeB-5gvbA:
undetectable		 3keeB-5gvbA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 741
GLU A 605
GLU A 581
TYR A 747
 None
 1.07A 3rqwC-5gvbA:
undetectable
3rqwD-5gvbA:
undetectable		 3rqwC-5gvbA:
19.64
3rqwD-5gvbA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLU A 605
GLU A 581
TYR A 747
TYR A 741
 None
 1.05A 3rqwF-5gvbA:
undetectable
3rqwJ-5gvbA:
undetectable		 3rqwF-5gvbA:
19.64
3rqwJ-5gvbA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 PHE A 584
TYR A 587
LEU A 540
 None
 0.76A 3sueB-5gvbA:
undetectable		 3sueB-5gvbA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 HIS A 579
GLY A 636
TYR A 741
GLU A 581
 None
 1.35A 4ae1B-5gvbA:
undetectable		 4ae1B-5gvbA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 498
ILE A 527
ALA A 547
PHE A 557
 None
 1.02A 4dc3B-5gvbA:
undetectable		 4dc3B-5gvbA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 812
LEU A 815
ALA A 816
MET A 788
LEU A 795
 None
 0.90A 4ltwA-5gvbA:
undetectable		 4ltwA-5gvbA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 TYR A 640
TRP A 658
LEU A 627
ALA A 548
ALA A 577
 None
 1.18A 4rn6A-5gvbA:
undetectable		 4rn6A-5gvbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 MET A 725
LEU A 764
LEU A 787
MET A 788
 None
 1.11A 5dxeA-5gvbA:
undetectable		 5dxeA-5gvbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ALA A 546
ALA A 548
VAL A 573
LEU A 554
LEU A 604
 None
 1.07A 5eb5A-5gvbA:
undetectable		 5eb5A-5gvbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 VAL A 782
GLU A 822
GLU A 818
 None
 0.88A 5jsdB-5gvbA:
undetectable
5jsdC-5gvbA:
undetectable		 5jsdB-5gvbA:
20.65
5jsdC-5gvbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 640
TRP A 658
THR A 657
LEU A 614
 None
 1.48A 5kxiA-5gvbA:
3.8
5kxiB-5gvbA:
3.8		 5kxiA-5gvbA:
21.05
5kxiB-5gvbA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 640
TRP A 658
THR A 657
LEU A 614
 None
 1.46A 5kxiD-5gvbA:
4.4
5kxiE-5gvbA:
3.9		 5kxiD-5gvbA:
21.05
5kxiE-5gvbA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 TYR A 741
PRO A 638
LEU A 650
 None
 0.79A 6beoA-5gvbA:
undetectable		 6beoA-5gvbA:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 MET A 725
LEU A 764
LEU A 787
MET A 788
 None
 1.12A 6cbzA-5gvbA:
undetectable		 6cbzA-5gvbA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 640
TRP A 658
THR A 657
LEU A 614
 None
 1.48A 6cnjD-5gvbA:
3.5
6cnjE-5gvbA:
4.6		 6cnjD-5gvbA:
10.80
6cnjE-5gvbA:
11.54