SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		4 / 8 PHE A 152
TYR A 336
CYH A 118
ARG A 149
 None
 1.45A 1xqlA-5gveA:
undetectable
1xqlB-5gveA:
undetectable		 1xqlA-5gveA:
21.43
1xqlB-5gveA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		4 / 8 ARG A 149
PHE A 152
TYR A 336
CYH A 118
 None
 1.46A 1xqlA-5gveA:
undetectable
1xqlB-5gveA:
undetectable		 1xqlA-5gveA:
21.43
1xqlB-5gveA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		4 / 5 LYS A  10
PRO A  11
SER A  37
SER A  16
 None
 0.88A 3ijxH-5gveA:
undetectable		 3ijxH-5gveA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		4 / 5 LYS A  10
PRO A  11
SER A  37
SER A  16
 None
 1.09A 3iluH-5gveA:
undetectable		 3iluH-5gveA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		4 / 8 TYR A 204
VAL A 543
ILE A 600
PHE A 200
 None
 0.69A 3uqbA-5gveA:
undetectable		 3uqbA-5gveA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		5 / 12 LEU A  21
MET A 164
ILE A  17
ALA A  14
LEU A  26
 None
 1.07A 3vrmA-5gveA:
undetectable		 3vrmA-5gveA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		5 / 12 GLY A 541
ASN A 539
GLN A 196
PHE A 200
ILE A 212
 None
 1.26A 4fglA-5gveA:
3.6
4fglB-5gveA:
3.5		 4fglA-5gveA:
18.06
4fglB-5gveA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		5 / 11 GLN A 196
PHE A 200
ILE A 212
GLY A 541
ASN A 539
 None
 1.42A 4fglA-5gveA:
3.6
4fglB-5gveA:
3.5		 4fglA-5gveA:
18.06
4fglB-5gveA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		4 / 5 PHE A 200
TYR A 199
PHE A 195
ILE A 212
 None
 1.21A 4jx1E-5gveA:
undetectable		 4jx1E-5gveA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		3 / 3 LYS A  10
PRO A  11
SER A  12
 None
 0.30A 4k50I-5gveA:
undetectable		 4k50I-5gveA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		4 / 6 ASN A 520
GLY A 189
PRO A 220
THR A 221
 None
 1.07A 4l1aB-5gveA:
undetectable		 4l1aB-5gveA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		5 / 12 GLU A 565
ARG A 181
ILE A 514
GLN A 319
ILE A 518
 None
 1.33A 4uroA-5gveA:
undetectable		 4uroA-5gveA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		5 / 12 LEU A 176
ALA A 180
GLU A 183
LEU A 582
LEU A 568
 None
 0.94A 4zn7A-5gveA:
undetectable		 4zn7A-5gveA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		4 / 6 GLU A 123
GLY A 122
ARG A 149
PHE A 152
 None
MG  A 701 ( 4.9A)
None
None
 1.37A 5jcnB-5gveA:
undetectable		 5jcnB-5gveA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		4 / 7 VAL A  61
GLU A  91
ILE A 112
VAL A 129
 None
 0.74A 5jh7C-5gveA:
undetectable		 5jh7C-5gveA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens) 		5 / 12 LEU A 301
HIS A 387
LEU A 328
ALA A 325
TYR A 409
 None
 1.09A 6djzC-5gveA:
undetectable		 6djzC-5gveA:
16.72