SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gvh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		5 / 9 GLY A 145
SER A 143
ALA A 170
HIS A 146
ILE A 137
 FMN  A 402 ( 4.3A)
FMN  A 402 (-4.4A)
FMN  A 402 ( 4.1A)
None
None
 1.12A 1gtfD-5gvhA:
undetectable
1gtfE-5gvhA:
undetectable		 1gtfD-5gvhA:
12.70
1gtfE-5gvhA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		4 / 6 THR A 194
GLY A 145
THR A 220
ILE A 147
 FMN  A 402 (-3.5A)
FMN  A 402 ( 4.3A)
None
None
 0.89A 1gtnD-5gvhA:
undetectable
1gtnE-5gvhA:
undetectable		 1gtnD-5gvhA:
12.70
1gtnE-5gvhA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		4 / 7 THR A 194
GLY A 145
THR A 220
ILE A 147
 FMN  A 402 (-3.5A)
FMN  A 402 ( 4.3A)
None
None
 0.92A 1gtnF-5gvhA:
undetectable
1gtnG-5gvhA:
undetectable		 1gtnF-5gvhA:
12.70
1gtnG-5gvhA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		4 / 7 THR A 194
GLY A 145
THR A 220
ILE A 147
 FMN  A 402 (-3.5A)
FMN  A 402 ( 4.3A)
None
None
 0.90A 1gtnJ-5gvhA:
undetectable
1gtnK-5gvhA:
undetectable		 1gtnJ-5gvhA:
12.70
1gtnK-5gvhA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		5 / 12 SER A 199
GLY A 193
GLY A  44
ALA A  31
VAL A  34
 None
FMN  A 402 (-3.4A)
None
None
None
 1.12A 1jg4A-5gvhA:
undetectable		 1jg4A-5gvhA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		5 / 12 GLY A  44
GLY A  21
ILE A  73
GLU A  59
ALA A  25
 None
FMN  A 402 (-4.2A)
FMN  A 402 (-4.9A)
None
FMN  A 402 ( 4.6A)
 1.05A 1nv8B-5gvhA:
undetectable		 1nv8B-5gvhA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		5 / 12 GLY A  44
GLY A  21
ILE A  73
GLU A  59
ALA A  25
 None
FMN  A 402 (-4.2A)
FMN  A 402 (-4.9A)
None
FMN  A 402 ( 4.6A)
 1.02A 1sg9B-5gvhA:
undetectable		 1sg9B-5gvhA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		5 / 12 GLY A  44
GLY A  21
ILE A  73
GLU A  59
ALA A  25
 None
FMN  A 402 (-4.2A)
FMN  A 402 (-4.9A)
None
FMN  A 402 ( 4.6A)
 1.01A 1vq1B-5gvhA:
undetectable		 1vq1B-5gvhA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		5 / 11 SER A  35
ILE A  43
ALA A  56
VAL A  91
PRO A  92
 None
 0.92A 2nnhA-5gvhA:
undetectable		 2nnhA-5gvhA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		4 / 7 ILE A 284
LEU A 283
GLY A 172
GLY A 278
 None
None
FMN  A 402 (-3.7A)
FMN  A 402 ( 4.0A)
 0.77A 2wd9A-5gvhA:
3.6		 2wd9A-5gvhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		4 / 8 ILE A 284
LEU A 283
GLY A 172
GLY A 278
 None
None
FMN  A 402 (-3.7A)
FMN  A 402 ( 4.0A)
 0.77A 2wd9B-5gvhA:
undetectable		 2wd9B-5gvhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		5 / 11 LEU A  18
MET A 192
GLY A  39
VAL A  34
ALA A 189
 None
 1.18A 2yy8A-5gvhA:
undetectable
2yy8B-5gvhA:
undetectable		 2yy8A-5gvhA:
21.14
2yy8B-5gvhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA500_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		4 / 4 ALA A 231
HIS A 146
HIS A 229
PRO A 230
 None
 1.38A 3mbgA-5gvhA:
0.0		 3mbgA-5gvhA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC900_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		4 / 4 ALA A 231
HIS A 146
HIS A 229
PRO A 230
 None
 1.38A 3mbgC-5gvhA:
0.0		 3mbgC-5gvhA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		5 / 10 ASP A 219
ALA A 215
ILE A 212
VAL A 277
VAL A 221
 None
NA  A 401 (-4.3A)
None
FMN  A 402 ( 4.9A)
None
 1.19A 3ogpB-5gvhA:
undetectable		 3ogpB-5gvhA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		5 / 12 ILE A 165
ASP A 134
LEU A 124
ILE A  73
ILE A  72
 None
None
None
FMN  A 402 (-4.9A)
None
 1.12A 3pwwA-5gvhA:
undetectable		 3pwwA-5gvhA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		5 / 12 ALA A  31
ILE A 173
MET A 192
GLY A 193
PHE A 196
 None
None
None
FMN  A 402 (-3.4A)
None
 1.01A 4r29D-5gvhA:
undetectable		 4r29D-5gvhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		4 / 8 ILE A  43
VAL A  70
GLU A  89
CYH A  86
 None
 0.86A 5dqyA-5gvhA:
undetectable		 5dqyA-5gvhA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		4 / 7 ILE A 173
ILE A 293
ILE A 284
SER A 280
 None
None
None
FMN  A 402 (-2.7A)
 0.77A 5fukA-5gvhA:
undetectable
5fukB-5gvhA:
undetectable		 5fukA-5gvhA:
24.38
5fukB-5gvhA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		4 / 7 VAL A 118
VAL A 128
PRO A 101
GLY A  99
 None
 0.81A 5x80C-5gvhA:
undetectable
5x80D-5gvhA:
undetectable		 5x80C-5gvhA:
20.77
5x80D-5gvhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		5 / 9 LEU A  18
PRO A  16
PHE A 301
LEU A 298
ILE A 294
 None
 1.34A 6fdyU-5gvhA:
undetectable		 6fdyU-5gvhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]
(Thermotoga
maritima) 		5 / 9 ILE A  43
ALA A  31
GLY A  41
LEU A  40
GLY A 193
 None
None
None
None
FMN  A 402 (-3.4A)
 1.30A 6nm4B-5gvhA:
undetectable		 6nm4B-5gvhA:
20.06