SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		5 / 11 ALA A 342
GLY A 223
ILE A 222
PRO A 213
ILE A 215
 None
 0.72A 1n49B-5gvsA:
undetectable		 1n49B-5gvsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		5 / 11 ALA A 342
GLY A 223
ILE A 222
PRO A 213
ILE A 215
 None
 0.77A 1n49C-5gvsA:
undetectable		 1n49C-5gvsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		4 / 8 ARG A 323
GLY A 322
THR A 360
ILE A 361
 None
 0.97A 2f9wA-5gvsA:
undetectable
2f9wB-5gvsA:
undetectable		 2f9wA-5gvsA:
22.49
2f9wB-5gvsA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		3 / 3 SER A 363
PHE A 365
LYS A 366
 None
 0.90A 3u88A-5gvsA:
undetectable		 3u88A-5gvsA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		4 / 5 GLU A 256
GLY A 313
TYR A 259
GLU A 247
 None
 1.13A 3w9tA-5gvsA:
undetectable		 3w9tA-5gvsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		4 / 6 GLU A 256
GLY A 313
TYR A 259
GLU A 247
 None
 1.13A 3w9tB-5gvsA:
undetectable		 3w9tB-5gvsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		4 / 5 GLU A 256
GLY A 313
TYR A 259
GLU A 247
 None
 1.13A 3w9tC-5gvsA:
undetectable		 3w9tC-5gvsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		4 / 5 GLU A 256
GLY A 313
TYR A 259
GLU A 247
 None
 1.13A 3w9tD-5gvsA:
undetectable		 3w9tD-5gvsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		4 / 6 GLU A 256
GLY A 313
TYR A 259
GLU A 247
 None
 1.13A 3w9tE-5gvsA:
undetectable		 3w9tE-5gvsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		4 / 6 GLU A 256
GLY A 313
TYR A 259
GLU A 247
 None
 1.10A 3w9tF-5gvsA:
undetectable		 3w9tF-5gvsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		4 / 5 GLU A 256
GLY A 313
TYR A 259
GLU A 247
 None
 1.13A 3w9tG-5gvsA:
undetectable		 3w9tG-5gvsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		4 / 7 LEU A 284
PRO A 189
LEU A 244
GLU A 245
 None
 0.91A 4z4fA-5gvsA:
undetectable		 4z4fA-5gvsA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		5 / 5 PHE A 226
ILE A 212
GLY A 230
ILE A 396
LEU A 233
 None
 1.35A 5dzkB-5gvsA:
undetectable
5dzkI-5gvsA:
undetectable
5dzkW-5gvsA:
undetectable		 5dzkB-5gvsA:
22.98
5dzkI-5gvsA:
19.42
5dzkW-5gvsA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5gvs PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens) 		4 / 7 LEU A 284
PRO A 189
LEU A 244
GLU A 245
 None
 0.78A 5t7bA-5gvsA:
undetectable		 5t7bA-5gvsA:
13.86