SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gvv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		4 / 7 VAL A 307
VAL A 289
TYR A 389
CYH A 280
 None
 1.17A 1t46A-5gvvA:
undetectable		 1t46A-5gvvA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		5 / 12 TYR A 309
VAL A 340
TYR A 346
ASN A 282
VAL A 281
 None
 1.09A 1x70A-5gvvA:
undetectable		 1x70A-5gvvA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		5 / 12 ARG A 353
VAL A 340
TYR A 346
ASN A 282
VAL A 281
 None
 1.05A 1x70B-5gvvA:
undetectable		 1x70B-5gvvA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		4 / 8 TYR A 385
CYH A 376
TYR A 346
TYR A 359
 None
 1.44A 1xqlA-5gvvA:
undetectable
1xqlB-5gvvA:
undetectable		 1xqlA-5gvvA:
22.10
1xqlB-5gvvA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		4 / 8 TYR A 346
TYR A 359
TYR A 385
CYH A 376
 None
 1.43A 1xqlA-5gvvA:
undetectable
1xqlB-5gvvA:
undetectable		 1xqlA-5gvvA:
22.10
1xqlB-5gvvA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		5 / 12 LEU A 103
LEU A 109
ILE A  20
GLY A  12
LEU A  39
 None
None
None
UDP  A 502 (-3.0A)
None
 0.93A 2j7xA-5gvvA:
undetectable		 2j7xA-5gvvA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		4 / 6 ASN A 324
GLN A  56
ILE A  63
PHE A  96
 None
 1.03A 2jn3A-5gvvA:
undetectable		 2jn3A-5gvvA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		5 / 11 LEU A 103
LEU A 118
SER A 191
LEU A 192
ASN A 197
 None
 0.96A 2xn5A-5gvvA:
undetectable		 2xn5A-5gvvA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		5 / 12 TYR A 309
VAL A 340
TYR A 346
ASN A 282
VAL A 281
 None
 1.13A 3bjmA-5gvvA:
undetectable		 3bjmA-5gvvA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		5 / 12 TYR A 309
VAL A 340
TYR A 346
ASN A 282
VAL A 281
 None
 1.13A 3bjmB-5gvvA:
undetectable		 3bjmB-5gvvA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		5 / 12 TYR A 309
VAL A 340
TYR A 346
ASN A 282
VAL A 281
 None
 1.25A 3g0bB-5gvvA:
2.4		 3g0bB-5gvvA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		5 / 12 TYR A 309
VAL A 340
TYR A 346
ASN A 282
VAL A 281
 None
 1.23A 3g0bC-5gvvA:
undetectable		 3g0bC-5gvvA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		5 / 12 TYR A 309
VAL A 340
TYR A 346
ASN A 282
VAL A 281
 None
 1.25A 3g0bD-5gvvA:
2.4		 3g0bD-5gvvA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		3 / 3 ASP A 348
ASN A 282
SER A 377
 None
 0.68A 3lslA-5gvvA:
1.4
3lslD-5gvvA:
1.5		 3lslA-5gvvA:
19.55
3lslD-5gvvA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		3 / 3 SER A 377
ASP A 348
ASN A 282
 None
 0.60A 3lslA-5gvvA:
1.7
3lslD-5gvvA:
1.8		 3lslA-5gvvA:
19.55
3lslD-5gvvA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		4 / 5 LEU A 226
ARG A 242
LEU A 222
PRO A 223
 None
 1.36A 3onnA-5gvvA:
undetectable		 3onnA-5gvvA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		5 / 12 TYR A 309
VAL A 340
TYR A 346
ASN A 282
VAL A 281
 None
 1.15A 3w2tA-5gvvA:
2.1		 3w2tA-5gvvA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		5 / 12 TYR A 309
VAL A 340
TYR A 346
ASN A 282
VAL A 281
 None
 1.13A 3w2tB-5gvvA:
undetectable		 3w2tB-5gvvA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		3 / 3 ARG A 321
PHE A 322
PRO A 323
 None
 0.26A 3zoaB-5gvvA:
undetectable		 3zoaB-5gvvA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		5 / 12 ARG A 353
VAL A 340
TYR A 346
ASN A 282
VAL A 281
 None
 0.98A 4ffwA-5gvvA:
2.4		 4ffwA-5gvvA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		5 / 12 TYR A 309
VAL A 340
TYR A 346
ASN A 282
VAL A 281
 None
 1.06A 4ffwA-5gvvA:
2.4		 4ffwA-5gvvA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		4 / 4 ASN A 150
TRP A 153
LEU A 162
PHE A  96
 None
 1.50A 4u15B-5gvvA:
0.0		 4u15B-5gvvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		4 / 7 ASP A 108
LEU A 109
ILE A 229
TYR A 104
 MN  A 501 ( 1.8A)
None
UDP  A 502 (-4.3A)
None
 0.98A 5zsfA-5gvvA:
undetectable
5zsfB-5gvvA:
undetectable		 5zsfA-5gvvA:
12.21
5zsfB-5gvvA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5gvv GLYCOSYL TRANSFERASE
FAMILY 8
(Streptococcus
pneumoniae) 		5 / 12 TYR A 309
VAL A 340
TYR A 346
ASN A 282
VAL A 281
 None
 1.14A 6b1eB-5gvvA:
undetectable		 6b1eB-5gvvA:
21.57