SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gvx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 145
THR A 307
LEU A 309
ALA A 337
 None
 1.43A 2e1qD-5gvxA:
undetectable		 2e1qD-5gvxA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 379
LEU A 152
LEU A 131
VAL A 350
ILE A 348
 None
 1.14A 2uxoB-5gvxA:
undetectable		 2uxoB-5gvxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 156
ASP A 158
LEU A 164
PHE A 148
THR A 193
 None
 1.49A 3j6gB-5gvxA:
undetectable		 3j6gB-5gvxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 156
ASP A 158
LEU A 164
PHE A 148
THR A 193
 None
 1.49A 3j6gD-5gvxA:
undetectable		 3j6gD-5gvxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 156
ASP A 158
LEU A 164
PHE A 148
THR A 193
 None
 1.49A 3j6gF-5gvxA:
undetectable		 3j6gF-5gvxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 156
ASP A 158
LEU A 164
PHE A 148
THR A 193
 None
 1.49A 3j6gH-5gvxA:
undetectable		 3j6gH-5gvxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 156
ASP A 158
LEU A 164
PHE A 148
THR A 193
 None
 1.49A 3j6gJ-5gvxA:
undetectable		 3j6gJ-5gvxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 156
ASP A 158
LEU A 164
PHE A 148
THR A 193
 None
 1.49A 3j6gL-5gvxA:
undetectable		 3j6gL-5gvxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 156
ASP A 158
LEU A 164
PHE A 148
THR A 193
 None
 1.49A 3j6gN-5gvxA:
undetectable		 3j6gN-5gvxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 156
ASP A 158
LEU A 164
PHE A 148
THR A 193
 None
 1.49A 3j6gP-5gvxA:
undetectable		 3j6gP-5gvxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 156
ASP A 158
LEU A 164
PHE A 148
THR A 193
 None
 1.49A 3j6gR-5gvxA:
undetectable		 3j6gR-5gvxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  39
ALA A  16
ASP A  15
VAL A 114
VAL A  67
 None
 1.05A 3oxwA-5gvxA:
undetectable		 3oxwA-5gvxA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 261
GLY A 270
PHE A 245
HIS A 260
GLU A 292
 None
 1.31A 3s8pB-5gvxA:
undetectable		 3s8pB-5gvxA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 250
VAL A 257
LEU A 296
VAL A 230
 None
 1.13A 4e1gB-5gvxA:
undetectable		 4e1gB-5gvxA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 237
ARG A 282
HIS A 283
 None
 0.81A 4kf9A-5gvxA:
undetectable		 4kf9A-5gvxA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 260
VAL A 249
GLU A 251
VAL A 293
 None
 1.38A 4p6vB-5gvxA:
undetectable
4p6vE-5gvxA:
1.9		 4p6vB-5gvxA:
22.15
4p6vE-5gvxA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 260
VAL A 250
GLU A 251
VAL A 293
 None
 1.17A 4p6vB-5gvxA:
undetectable
4p6vE-5gvxA:
1.9		 4p6vB-5gvxA:
22.15
4p6vE-5gvxA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 152
GLY A 329
PHE A 148
ASP A 355
ALA A 362
 None
 0.99A 4pclA-5gvxA:
3.1		 4pclA-5gvxA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 205
GLU A 210
ASP A 147
ASP A 188
 None
None
MG  A 401 ( 2.9A)
None
 0.99A 4uckB-5gvxA:
undetectable		 4uckB-5gvxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 330
ARG A  13
ARG A  63
 MG  A 401 ( 2.3A)
None
None
 0.94A 5eajB-5gvxA:
undetectable		 5eajB-5gvxA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 231
LYS A 232
ALA A 235
LEU A 238
 None
 0.67A 5vkqA-5gvxA:
2.5
5vkqD-5gvxA:
2.4		 5vkqA-5gvxA:
13.38
5vkqD-5gvxA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 231
LYS A 232
ALA A 235
LEU A 238
 None
 0.66A 5vkqA-5gvxA:
2.5
5vkqB-5gvxA:
2.5		 5vkqA-5gvxA:
13.38
5vkqB-5gvxA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 231
LYS A 232
ALA A 235
LEU A 238
 None
 0.66A 5vkqB-5gvxA:
2.5
5vkqC-5gvxA:
2.5		 5vkqB-5gvxA:
13.38
5vkqC-5gvxA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 231
LYS A 232
ALA A 235
LEU A 238
 None
 0.66A 5vkqC-5gvxA:
2.5
5vkqD-5gvxA:
2.4		 5vkqC-5gvxA:
13.38
5vkqD-5gvxA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 340
GLY A 305
ASP A 336
ASP A 334
 None
 1.22A 6cjkC-5gvxA:
undetectable		 6cjkC-5gvxA:
18.89