SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gw4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		3 / 3 MET g  78
LEU g  81
SER g  82
 None
 0.65A 1ee2A-5gw4g:
undetectable		 1ee2A-5gw4g:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		5 / 12 MET g 449
VAL g 445
LEU g 427
ALA g 513
ILE g 136
 None
 0.98A 1epbA-5gw4g:
undetectable		 1epbA-5gw4g:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		5 / 11 LEU g 396
ALA g 399
ALA g 178
LEU g 176
VAL g 206
 None
 1.24A 1ictA-5gw4g:
undetectable
1ictC-5gw4g:
undetectable		 1ictA-5gw4g:
13.74
1ictC-5gw4g:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		5 / 12 ILE g  98
LEU g 456
GLY g 101
THR g 455
LEU g  39
 None
 1.03A 1liiA-5gw4g:
undetectable		 1liiA-5gw4g:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		3 / 3 ASP g 398
ASP g  91
LYS g 162
 None
 1.06A 1lqtB-5gw4g:
undetectable		 1lqtB-5gw4g:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		3 / 3 ASP g 398
ASP g  91
LYS g 162
 None
 1.07A 1lquB-5gw4g:
undetectable		 1lquB-5gw4g:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		4 / 6 LEU g 246
LEU g 343
PRO g 292
VAL g 290
 None
 1.21A 2dqyC-5gw4g:
undetectable		 2dqyC-5gw4g:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		4 / 7 ALA g 376
ARG g 330
ASP g 199
TYR g 203
 None
 1.08A 2e5dA-5gw4g:
undetectable
2e5dB-5gw4g:
undetectable		 2e5dA-5gw4g:
24.07
2e5dB-5gw4g:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		4 / 7 ASP g 199
TYR g 203
ALA g 376
ARG g 330
 None
 1.22A 2e5dA-5gw4g:
undetectable
2e5dB-5gw4g:
undetectable		 2e5dA-5gw4g:
24.07
2e5dB-5gw4g:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		5 / 12 ALA g 399
ASP g 398
GLY g 160
ILE g 165
ILE g 155
 None
 1.02A 3mwsA-5gw4g:
undetectable		 3mwsA-5gw4g:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		5 / 9 ALA g 399
ASP g 398
GLY g 160
ILE g 165
ILE g 155
 None
 1.12A 3ndwB-5gw4g:
undetectable		 3ndwB-5gw4g:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		5 / 12 ALA g 399
GLN g 397
ILE g 198
LEU g 176
VAL g 179
 None
 1.26A 4azwA-5gw4g:
undetectable		 4azwA-5gw4g:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		4 / 7 ILE g 484
GLY g 498
ALA g 418
GLN g 156
 None
 0.93A 4g0uB-5gw4g:
1.1		 4g0uB-5gw4g:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		3 / 3 LYS g 375
TYR g 203
ARG g 330
 None
 1.20A 4gc9A-5gw4g:
undetectable		 4gc9A-5gw4g:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		5 / 12 ALA g 399
ASP g 398
GLY g 160
ILE g 165
ILE g 155
 None
 1.08A 4njvA-5gw4g:
undetectable		 4njvA-5gw4g:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		4 / 6 ILE g  22
GLN g  21
ILE g 526
ASP g 525
 None
 1.13A 4w5tA-5gw4g:
undetectable		 4w5tA-5gw4g:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		4 / 7 VAL g 143
LEU g 412
SER g 413
GLU g 503
 None
 1.01A 4zphA-5gw4g:
undetectable
4zphB-5gw4g:
undetectable		 4zphA-5gw4g:
22.04
4zphB-5gw4g:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		4 / 6 ARG g 394
ASP g  86
GLY g  90
ASP g 398
 None
 1.23A 5hp1A-5gw4g:
undetectable		 5hp1A-5gw4g:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		5 / 12 ALA g 399
ASP g 398
GLY g 160
ILE g 165
ILE g 155
 None
 1.03A 5t2zA-5gw4g:
undetectable		 5t2zA-5gw4g:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		4 / 7 ILE g 122
LEU g 521
ILE g 437
ALA g 108
 None
 0.86A 6b5vA-5gw4g:
undetectable
6b5vC-5gw4g:
undetectable		 6b5vA-5gw4g:
9.36
6b5vC-5gw4g:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		4 / 7 ILE g 122
LEU g 521
ILE g 437
ALA g 108
 None
 0.86A 6b5vC-5gw4g:
undetectable
6b5vD-5gw4g:
undetectable		 6b5vC-5gw4g:
9.36
6b5vD-5gw4g:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		4 / 7 ALA g 108
ILE g 122
LEU g 521
ILE g 437
 None
 0.86A 6b5vB-5gw4g:
0.9
6b5vD-5gw4g:
undetectable		 6b5vB-5gw4g:
9.36
6b5vD-5gw4g:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		4 / 6 ILE g  22
GLN g  21
ILE g 526
ASP g 525
 None
 1.21A 6cbdA-5gw4g:
undetectable		 6cbdA-5gw4g:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 5gw4 T-COMPLEX PROTEIN 1
SUBUNIT GAMMA
(Saccharomyces
cerevisiae) 		4 / 8 LYS g 127
ALA g 128
LEU g 427
ALA g 446
 None
 0.76A 6mdqA-5gw4g:
undetectable		 6mdqA-5gw4g:
10.65