SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gw5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 PHE b 433
LEU b 437
ALA b 131
LEU b 132
ILE b  80
 None
 1.14A 1crbA-5gw5b:
undetectable		 1crbA-5gw5b:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA
T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		5 / 12 ILE d  48
ILE d  35
LEU a  13
LEU a  15
ILE a 545
 None
 0.91A 1df7A-5gw5d:
undetectable		 1df7A-5gw5d:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
(Saccharomyces
cerevisiae) 		5 / 11 VAL h 420
LEU h 507
ILE h 439
ALA h 443
LEU h 446
 None
 1.03A 1eqgB-5gw5h:
0.6		 1eqgB-5gw5h:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		5 / 10 GLY z  90
THR z  87
GLY z 519
ALA z  79
ILE z 523
 None
 1.13A 1gtfJ-5gw5z:
undetectable
1gtfK-5gw5z:
undetectable		 1gtfJ-5gw5z:
8.97
1gtfK-5gw5z:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 4 SER b 389
GLU b  87
SER b  81
ASP b  90
 None
 1.02A 1h1dA-5gw5b:
undetectable		 1h1dA-5gw5b:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		5 / 12 ILE d  98
LEU d 454
GLY d 101
THR d 453
LEU d  39
 None
 1.02A 1liiA-5gw5d:
undetectable		 1liiA-5gw5d:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		4 / 6 ALA q 527
LEU q 521
LEU q 139
LEU q 430
 None
 0.95A 1mt1D-5gw5q:
undetectable
1mt1E-5gw5q:
undetectable		 1mt1D-5gw5q:
13.88
1mt1E-5gw5q:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 ILE e  83
VAL b 511
ALA b 100
SER b  99
LEU b  32
 None
 1.08A 1nbhB-5gw5e:
undetectable		 1nbhB-5gw5e:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		4 / 7 ILE z 506
ALA z 417
ILE z 138
PRO z 501
 None
 0.92A 1oniB-5gw5z:
undetectable
1oniC-5gw5z:
undetectable		 1oniB-5gw5z:
13.42
1oniC-5gw5z:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 ASP b  85
THR b  62
GLU b 379
 None
 0.79A 1pj7A-5gw5b:
undetectable		 1pj7A-5gw5b:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 LEU b 493
ALA b 130
ALA b 414
ALA b 131
VAL b 497
 None
 1.18A 1rbpA-5gw5b:
undetectable		 1rbpA-5gw5b:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 THR a 333
VAL a 295
VAL a 242
LEU a 224
ILE a 374
 None
 1.08A 1t6zB-5gw5a:
undetectable		 1t6zB-5gw5a:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		6 / 12 LEU a 108
LEU a 532
LEU a 455
ALA a 454
ILE a 126
LEU a 539
 None
 1.37A 1tw4A-5gw5a:
undetectable		 1tw4A-5gw5a:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		4 / 5 LEU q 111
GLY q 108
HIS q  39
ILE q  35
 None
 0.95A 1xf1A-5gw5q:
2.6		 1xf1A-5gw5q:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		5 / 12 ILE q 318
VAL q 305
LEU q 344
ILE q 284
MET q 287
 None
 1.00A 1xozA-5gw5q:
undetectable		 1xozA-5gw5q:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		3 / 3 PHE z 136
ARG z 511
ASN z 410
 None
 0.85A 1xzxX-5gw5z:
undetectable		 1xzxX-5gw5z:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		4 / 4 LEU z 328
SER z 351
LEU z 317
LEU z 215
 None
 1.15A 1yajA-5gw5z:
undetectable		 1yajA-5gw5z:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		5 / 9 THR q 138
LEU q 139
GLU q 533
ALA q 531
LEU q 106
 None
 1.41A 2azqA-5gw5q:
undetectable		 2azqA-5gw5q:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 PHE a 139
PHE a 436
ALA a 428
ILE a 448
LEU a 455
 None
 1.02A 2bjfA-5gw5a:
undetectable		 2bjfA-5gw5a:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		3 / 3 LYS z  40
ASP z 497
ASN z 494
 None
 0.99A 2bm9A-5gw5z:
undetectable		 2bm9A-5gw5z:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
(Saccharomyces
cerevisiae) 		5 / 12 LEU h 189
GLY h 217
ARG h 325
ASP h 322
ASN h 216
 None
 1.22A 2bm9B-5gw5h:
undetectable		 2bm9B-5gw5h:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		4 / 4 VAL z 491
LEU z  97
ILE z 517
LEU z 513
 None
 1.02A 2byoA-5gw5z:
undetectable		 2byoA-5gw5z:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		4 / 7 ARG b 516
GLU e  80
LYS b  75
ASN b  79
 None
 1.24A 2ejgA-5gw5b:
undetectable		 2ejgA-5gw5b:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		5 / 12 PHE z 418
GLY z 414
GLY z 490
ILE z 517
LEU z 133
 None
 0.95A 2hmyB-5gw5z:
undetectable		 2hmyB-5gw5z:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 SER b 113
LEU b 428
ASP b 111
GLU b 105
 None
 1.19A 2j2pE-5gw5b:
undetectable
2j2pF-5gw5b:
undetectable		 2j2pE-5gw5b:
19.22
2j2pF-5gw5b:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		4 / 7 ASP q  67
THR q  65
ILE h 524
ASN h 526
 None
 1.14A 2jc9A-5gw5q:
undetectable		 2jc9A-5gw5q:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		4 / 7 VAL z 331
THR z 332
THR z 371
LYS z 211
 None
 1.15A 2kotA-5gw5z:
undetectable		 2kotA-5gw5z:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		5 / 11 ARG d 380
GLY d 201
ILE d 353
THR d 364
VAL d 378
 None
 1.06A 2nnhA-5gw5d:
undetectable		 2nnhA-5gw5d:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		5 / 9 ARG d 380
GLY d 201
ILE d 353
THR d 364
VAL d 378
 None
 1.05A 2nnhB-5gw5d:
undetectable		 2nnhB-5gw5d:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		4 / 7 LEU z 328
VAL z 331
THR z 332
VAL z 354
 None
 0.94A 2qblA-5gw5z:
undetectable		 2qblA-5gw5z:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA q  34
GLU q  37
LEU q  38
LEU h  13
ILE h  10
 None
 1.01A 2qxsB-5gw5q:
undetectable		 2qxsB-5gw5q:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 PHE a 139
PHE a 436
ALA a 428
ILE a 448
LEU a 455
 None
 0.98A 2rlcA-5gw5a:
undetectable		 2rlcA-5gw5a:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		5 / 12 LEU b 103
ASN b  71
ARG b 510
VAL b  76
ILE e  73
 None
 1.43A 2xpwA-5gw5b:
1.4		 2xpwA-5gw5b:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		5 / 12 THR e 119
GLY e 121
GLY e  87
LEU e  91
ILE e  61
 None
 1.16A 2y7kD-5gw5e:
undetectable		 2y7kD-5gw5e:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 ALA b 364
GLY b 358
CYH b 359
LYS b 360
 None
 1.45A 2ylgA-5gw5b:
2.6		 2ylgA-5gw5b:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		5 / 11 VAL q 189
SER q 379
VAL q 182
ILE q 384
ALA q 406
 None
 1.16A 2zbzA-5gw5q:
undetectable		 2zbzA-5gw5q:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		3 / 3 MET z 130
GLU z 123
ASN z 526
 None
 1.08A 3a27A-5gw5z:
undetectable		 3a27A-5gw5z:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 SER b 389
GLU b  87
ASP b  90
 None
 0.87A 3bwmA-5gw5b:
undetectable		 3bwmA-5gw5b:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 6 ALA b 134
LEU b 132
SER b 128
VAL b 410
 None
 1.07A 3d2tB-5gw5b:
undetectable		 3d2tB-5gw5b:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		5 / 12 LEU b  46
LEU b  64
LEU b  69
ALA d 525
THR b  57
 None
 1.02A 3dfrA-5gw5b:
undetectable		 3dfrA-5gw5b:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
(Saccharomyces
cerevisiae) 		3 / 3 GLU h 419
VAL h 420
CYH h 423
 None
 1.02A 3fbxA-5gw5h:
undetectable		 3fbxA-5gw5h:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ALA b 501
GLY b  91
ILE b  80
LEU b  77
SER b  81
 None
 1.33A 3gyqA-5gw5b:
2.5
3gyqB-5gw5b:
2.6		 3gyqA-5gw5b:
22.50
3gyqB-5gw5b:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
T-COMPLEX PROTEIN 1
SUBUNIT ETA
(Saccharomyces
cerevisiae) 		5 / 12 GLY e 118
ILE e 115
GLY h 381
ALA h 382
LEU e 107
 None
 1.02A 3hs6B-5gw5e:
undetectable		 3hs6B-5gw5e:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 9 ASP b 205
LEU b 203
THR b 376
ILE b 198
LEU b 369
 None
 1.33A 3hy7A-5gw5b:
undetectable		 3hy7A-5gw5b:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
T-COMPLEX PROTEIN 1
SUBUNIT ETA
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 ALA h 257
PRO e 364
PHE e 366
ILE h 270
ALA h 273
 None
 0.97A 3jb1A-5gw5h:
undetectable		 3jb1A-5gw5h:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 ALA b 100
ARG b 104
LYS b 108
 None
 0.78A 3kp3B-5gw5b:
2.3		 3kp3B-5gw5b:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
(Saccharomyces
cerevisiae) 		5 / 11 VAL h 101
GLY h 106
SER h  87
THR h 514
ALA h 513
 None
 1.27A 3kw2A-5gw5h:
undetectable		 3kw2A-5gw5h:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		4 / 6 ILE d 321
ASP d 211
GLY d 327
VAL d 197
 None
 0.95A 3n3iA-5gw5d:
undetectable		 3n3iA-5gw5d:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		4 / 5 VAL d 312
LEU d 286
ILE d 241
ALA d 301
 None
 0.93A 3n8yB-5gw5d:
1.1		 3n8yB-5gw5d:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		3 / 3 LYS q  93
ARG q  73
ASP q 205
 None
 1.12A 3o7wA-5gw5q:
undetectable		 3o7wA-5gw5q:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		3 / 3 LYS d 198
ARG d 195
LYS d 290
 None
 1.30A 3okxA-5gw5d:
undetectable		 3okxA-5gw5d:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 9 ILE a 125
ILE a 126
ALA a 537
LEU a 539
ALA a 447
 None
 0.96A 3ozvB-5gw5a:
undetectable		 3ozvB-5gw5a:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 9 ILE b 193
ILE b 195
ALA b 380
LEU b 384
LEU b 208
 None
 1.10A 3ozvB-5gw5b:
undetectable		 3ozvB-5gw5b:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		5 / 12 GLY e 443
GLY e 511
VAL e 448
THR e 482
LEU e 483
 None
 1.10A 3p2kB-5gw5e:
undetectable		 3p2kB-5gw5e:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 ASP b 386
GLY b  89
GLY b  60
ASP b 378
ASP b  85
 None
 1.10A 3prsA-5gw5b:
undetectable		 3prsA-5gw5b:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 LEU b 440
LEU b 437
ALA b 436
LEU b 102
GLY b  30
 None
 1.09A 3q95B-5gw5b:
undetectable		 3q95B-5gw5b:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		5 / 11 SER e  64
ILE e  61
VAL e 124
VAL e 123
ILE e 479
 None
 1.39A 3rf4A-5gw5e:
undetectable
3rf4C-5gw5e:
undetectable		 3rf4A-5gw5e:
14.13
3rf4C-5gw5e:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		5 / 11 ILE e 479
SER e  64
ILE e  61
VAL e 124
VAL e 123
 None
 1.37A 3rf4A-5gw5e:
undetectable
3rf4B-5gw5e:
undetectable		 3rf4A-5gw5e:
14.13
3rf4B-5gw5e:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		5 / 11 ILE e 479
SER e  64
ILE e  61
VAL e 124
VAL e 123
 None
 1.35A 3rf4B-5gw5e:
undetectable
3rf4C-5gw5e:
undetectable		 3rf4B-5gw5e:
14.13
3rf4C-5gw5e:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
(Saccharomyces
cerevisiae) 		4 / 6 LEU h 282
ALA h 290
THR h 288
LEU h 244
 None
 0.99A 3t3zA-5gw5h:
undetectable		 3t3zA-5gw5h:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
(Saccharomyces
cerevisiae) 		4 / 6 LEU h 282
ALA h 290
THR h 288
LEU h 244
 None
 0.97A 3t3zB-5gw5h:
undetectable		 3t3zB-5gw5h:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
(Saccharomyces
cerevisiae) 		4 / 6 LEU h 282
ALA h 290
THR h 288
LEU h 244
 None
 1.01A 3t3zD-5gw5h:
undetectable		 3t3zD-5gw5h:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
(Saccharomyces
cerevisiae) 		5 / 12 GLY h 347
ILE h 241
THR h 288
VAL h 285
ILE h 341
 None
 0.95A 3tkgC-5gw5h:
undetectable		 3tkgC-5gw5h:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		4 / 4 ASP e 390
ASP e 246
GLY e 228
THR e 405
 None
 1.33A 3tl9B-5gw5e:
undetectable		 3tl9B-5gw5e:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA
T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 GLY d 459
THR a 123
ASN d 457
 None
 0.69A 3v4tD-5gw5d:
undetectable		 3v4tD-5gw5d:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 GLY b 449
THR d 118
ASN b 447
 None
 0.67A 3v4tD-5gw5b:
undetectable		 3v4tD-5gw5b:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 LEU a  44
LEU a 462
ASN a 465
LEU a 504
VAL a 474
 None
 1.24A 3zqtA-5gw5a:
undetectable		 3zqtA-5gw5a:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 LEU b  37
LEU b 444
ASN b 447
LEU b 474
VAL b 456
 None
 1.34A 3zqtA-5gw5b:
2.2		 3zqtA-5gw5b:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
(Saccharomyces
cerevisiae) 		3 / 3 GLN h 232
ASP h 309
GLN h 305
 None
 0.92A 4aztA-5gw5h:
undetectable		 4aztA-5gw5h:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		5 / 12 LEU b 103
ASN b  71
ARG b 510
VAL b  76
ILE e  73
 None
 1.36A 4b3aA-5gw5b:
2.8		 4b3aA-5gw5b:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		5 / 12 GLU q 290
ILE q 299
GLY q 345
GLN q 283
ILE q 291
 None
 1.47A 4djfA-5gw5q:
undetectable		 4djfA-5gw5q:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
(Saccharomyces
cerevisiae) 		3 / 3 LYS h 110
LYS h 113
PRO h 114
 None
 1.28A 4dv1L-5gw5h:
undetectable		 4dv1L-5gw5h:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		4 / 8 SER z 423
ILE z 118
VAL z 113
PHE z 108
 None
 0.99A 4dx7B-5gw5z:
3.2		 4dx7B-5gw5z:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		6 / 12 VAL d 515
ALA d 511
PHE d 443
PHE d 124
SER d 123
LEU d 110
 None
 1.31A 4eckA-5gw5d:
undetectable		 4eckA-5gw5d:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		5 / 12 VAL d 515
ALA d 511
PHE d 124
SER d 123
LEU d 110
 None
 1.08A 4eckB-5gw5d:
undetectable		 4eckB-5gw5d:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		4 / 6 GLU b  12
ILE b 515
ASN b 513
VAL e 123
 None
 1.09A 4ejwB-5gw5b:
undetectable		 4ejwB-5gw5b:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		4 / 6 GLU q  74
ILE h 524
ASN h 526
VAL q  82
 None
 0.98A 4ejwB-5gw5q:
undetectable		 4ejwB-5gw5q:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 GLY b 371
GLY b 201
SER b 204
ALA b 380
ILE b 165
 None
 0.96A 4krhA-5gw5b:
undetectable		 4krhA-5gw5b:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		5 / 12 GLY e 410
GLY e 232
SER e 235
ALA e 419
ILE e 192
 None
 1.00A 4krhA-5gw5e:
undetectable		 4krhA-5gw5e:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 GLY b 371
GLY b 201
SER b 204
ALA b 380
ILE b 165
 None
 0.98A 4krhB-5gw5b:
undetectable		 4krhB-5gw5b:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		5 / 12 GLY e 410
GLY e 232
SER e 235
ALA e 419
ILE e 192
 None
 1.02A 4krhB-5gw5e:
undetectable		 4krhB-5gw5e:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA
T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		5 / 12 ILE d  48
ILE d  35
LEU a  13
LEU a  15
ILE a 545
 None
 0.98A 4m2xA-5gw5d:
undetectable		 4m2xA-5gw5d:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA
T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		6 / 12 ILE d  48
ILE d  35
LEU a  13
LEU a  15
ILE a 545
THR d  63
 None
 1.27A 4m2xC-5gw5d:
undetectable		 4m2xC-5gw5d:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA
T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		5 / 12 ILE d  48
ILE d  35
LEU a  13
LEU a  15
ILE a 545
 None
 1.01A 4m2xE-5gw5d:
undetectable		 4m2xE-5gw5d:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM7_A_29JA603_1
(TRANSPORTER)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 10 ASP b 481
VAL b 488
GLY b 404
ASP b 152
THR b 400
 None
 1.44A 4mm7A-5gw5b:
undetectable		 4mm7A-5gw5b:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
(Saccharomyces
cerevisiae) 		4 / 7 ILE h 292
PHE h 365
LEU h 294
THR h 223
 None
 1.00A 4mmcA-5gw5h:
1.2		 4mmcA-5gw5h:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		4 / 5 PRO e 275
GLY e 326
ASP e 311
ASP e 328
 None
 1.14A 4n48B-5gw5e:
undetectable		 4n48B-5gw5e:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 11 ALA b 414
ARG b 438
LEU b 437
ALA b 434
VAL b 401
 None
 0.99A 4nqaA-5gw5b:
undetectable		 4nqaA-5gw5b:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		5 / 11 ILE q  35
ALA q 107
LYS q  83
SER q 540
ILE q 541
 None
 1.29A 4qi9C-5gw5q:
undetectable		 4qi9C-5gw5q:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 9 SER b 462
ILE b 463
ASP b 481
ALA b 480
THR b 478
 None
 1.17A 4r1zA-5gw5b:
undetectable		 4r1zA-5gw5b:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 GLU b  12
ARG b  14
GLN b   4
 None
 0.89A 4rtbA-5gw5b:
undetectable		 4rtbA-5gw5b:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLY z  49
ALA z  50
SER q  20
PRO q  80
GLN q  27
 None
 1.24A 4rtpA-5gw5z:
undetectable		 4rtpA-5gw5z:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		3 / 3 LYS q 171
ARG q  51
VAL h 520
 None
 0.84A 4x3uA-5gw5q:
undetectable
4x3uB-5gw5q:
undetectable		 4x3uA-5gw5q:
7.93
4x3uB-5gw5q:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		5 / 12 THR q 339
ALA q 338
LEU q 352
GLY q 302
PRO q 347
 None
 0.95A 4xi3B-5gw5q:
undetectable		 4xi3B-5gw5q:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 4 SER b 389
GLU b  87
SER b  81
ASP b  90
 None
 1.06A 4xucA-5gw5b:
undetectable		 4xucA-5gw5b:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		3 / 3 SER b 389
GLU b  87
ASP b  90
 None
 0.84A 4xudA-5gw5b:
undetectable		 4xudA-5gw5b:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		6 / 9 LEU b  98
LEU b 437
ALA b 131
ALA b 127
LEU b 102
ALA b 501
 None
 1.22A 4z91F-5gw5b:
2.5
4z91G-5gw5b:
1.8
4z91H-5gw5b:
2.6
4z91I-5gw5b:
2.9
4z91J-5gw5b:
1.8		 4z91F-5gw5b:
20.49
4z91G-5gw5b:
20.49
4z91H-5gw5b:
20.49
4z91I-5gw5b:
20.49
4z91J-5gw5b:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		6 / 10 ALA d 127
LEU d 425
ALA d 429
SER d 445
LEU d 447
ALA d 444
 None
 1.35A 4zbrA-5gw5d:
undetectable		 4zbrA-5gw5d:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
(Saccharomyces
cerevisiae) 		5 / 10 ALA h 510
LEU h  83
LEU h 108
LEU h 446
ALA h 445
 None
 1.03A 4zbrA-5gw5h:
undetectable		 4zbrA-5gw5h:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		4 / 7 ILE d 360
VAL d 214
ILE d 210
GLU d 208
 None
 0.98A 4zzbC-5gw5d:
undetectable
4zzbD-5gw5d:
undetectable		 4zzbC-5gw5d:
19.96
4zzbD-5gw5d:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		4 / 6 ILE e 532
ARG e 431
ILE e 115
GLU e 114
 None
 1.04A 4zzcA-5gw5e:
undetectable
4zzcB-5gw5e:
undetectable		 4zzcA-5gw5e:
21.21
4zzcB-5gw5e:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		5 / 10 GLY z  90
THR z  87
GLY z 519
ALA z  79
ILE z 523
 None
 1.12A 5eevA-5gw5z:
undetectable
5eevB-5gw5z:
undetectable		 5eevA-5gw5z:
8.97
5eevB-5gw5z:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		5 / 10 GLY z  90
THR z  87
GLY z 519
ALA z  79
ILE z 523
 None
 1.12A 5eewA-5gw5z:
undetectable
5eewB-5gw5z:
undetectable		 5eewA-5gw5z:
8.97
5eewB-5gw5z:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		5 / 10 GLY z  90
THR z  87
GLY z 519
ALA z  79
ILE z 523
 None
 1.12A 5eexA-5gw5z:
undetectable
5eexB-5gw5z:
undetectable		 5eexA-5gw5z:
8.97
5eexB-5gw5z:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		5 / 10 GLY z  90
THR z  87
GLY z 519
ALA z  79
ILE z 523
 None
 1.12A 5eeyA-5gw5z:
undetectable
5eeyB-5gw5z:
undetectable		 5eeyA-5gw5z:
8.97
5eeyB-5gw5z:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		5 / 10 GLY z  90
THR z  87
GLY z 519
ALA z  79
ILE z 523
 None
 1.11A 5eezA-5gw5z:
undetectable
5eezB-5gw5z:
undetectable		 5eezA-5gw5z:
8.97
5eezB-5gw5z:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		5 / 10 GLY z  90
THR z  87
GLY z 519
ALA z  79
ILE z 523
 None
 1.12A 5ef0A-5gw5z:
undetectable
5ef0B-5gw5z:
undetectable		 5ef0A-5gw5z:
8.97
5ef0B-5gw5z:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		5 / 10 GLY z  90
THR z  87
GLY z 519
ALA z  79
ILE z 523
 None
 1.11A 5ef1A-5gw5z:
undetectable
5ef1B-5gw5z:
undetectable		 5ef1A-5gw5z:
8.97
5ef1B-5gw5z:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		5 / 10 GLY z  90
THR z  87
GLY z 519
ALA z  79
ILE z 523
 None
 1.11A 5ef2A-5gw5z:
undetectable
5ef2B-5gw5z:
undetectable		 5ef2A-5gw5z:
8.97
5ef2B-5gw5z:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		5 / 10 GLY z  90
THR z  87
GLY z 519
ALA z  79
ILE z 523
 None
 1.12A 5ef3A-5gw5z:
undetectable
5ef3B-5gw5z:
undetectable		 5ef3A-5gw5z:
8.97
5ef3B-5gw5z:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		5 / 12 GLN q 373
ILE q 223
HIS q 245
VAL q 300
LEU q 332
 None
 0.98A 5ergB-5gw5q:
undetectable		 5ergB-5gw5q:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 SER b 389
GLU b  87
SER b  81
ASP b  90
 None
 1.05A 5fhrB-5gw5b:
undetectable		 5fhrB-5gw5b:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		5 / 12 LEU q 117
ILE q  29
GLY q  26
ASP q  25
LEU q 122
 None
 1.15A 5h5fA-5gw5q:
2.0		 5h5fA-5gw5q:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		5 / 12 LEU q 122
ILE q  29
GLY q  26
ASP q  25
ALA q 124
 None
 1.15A 5h5fA-5gw5q:
2.0		 5h5fA-5gw5q:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		3 / 3 GLY d 415
GLY d 414
GLN d 499
 None
 0.36A 5imsA-5gw5d:
undetectable		 5imsA-5gw5d:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 THR a 439
ALA a 449
ALA a 453
LEU a 456
PHE a 436
 None
 1.27A 5jglA-5gw5a:
undetectable		 5jglA-5gw5a:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 5 ALA b 364
GLY b 358
CYH b 359
LYS b 360
 None
 1.48A 5jliA-5gw5b:
2.6		 5jliA-5gw5b:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 PHE b 433
LEU b 102
ALA b 436
LEU b 135
LEU b 132
 None
 1.04A 5ljeA-5gw5b:
undetectable		 5ljeA-5gw5b:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		5 / 9 ILE e 271
VAL e 320
GLU e 350
LEU e 393
ILE e 395
 None
 1.42A 5mzpA-5gw5e:
undetectable		 5mzpA-5gw5e:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		5 / 11 LEU z 528
GLY z 121
LEU z 102
THR z 521
ALA z 524
 None
 1.14A 5o96A-5gw5z:
3.4
5o96B-5gw5z:
undetectable		 5o96A-5gw5z:
20.26
5o96B-5gw5z:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		5 / 12 LEU e 540
GLN e 111
ARG e 431
PRO e 530
ASN e 432
 None
 1.31A 5uhgC-5gw5e:
undetectable		 5uhgC-5gw5e:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 4 LEU b  98
LEU b 102
SER b 500
ALA b 505
 None
 1.10A 5uunA-5gw5b:
undetectable		 5uunA-5gw5b:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		5 / 12 THR z 521
LEU z 101
ILE z 444
GLU z 123
THR z 440
 None
 1.30A 5w8aA-5gw5z:
undetectable		 5w8aA-5gw5z:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 GLY b 200
GLY b 349
VAL b 368
LEU b 369
GLY b 371
 None
 1.08A 5wyqA-5gw5b:
undetectable		 5wyqA-5gw5b:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 LEU a 413
VAL a 181
ASP a 182
 None
 0.66A 5x23A-5gw5a:
undetectable		 5x23A-5gw5a:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_1
(CARNOSINE
N-METHYLTRANSFERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		4 / 5 GLN q  40
ARG q  36
GLU q 465
ASP q 470
 None
 1.18A 5yf0A-5gw5q:
0.0		 5yf0A-5gw5q:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 GLN b 393
GLY b  91
ASP b  90
VAL b 390
ALA b 496
 None
 0.98A 6bq4A-5gw5b:
undetectable		 6bq4A-5gw5b:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 GLN b 393
GLY b  91
ASP b  90
VAL b 390
ALA b 496
 None
 1.02A 6bq4B-5gw5b:
undetectable		 6bq4B-5gw5b:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 VAL a 517
LEU a 455
ARG a 478
PRO a 459
 None
 1.28A 6brdB-5gw5a:
undetectable		 6brdB-5gw5a:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		5 / 12 GLY e 317
ALA e 318
ASP e 319
GLY e 375
VAL e 363
 None
 0.93A 6dj1B-5gw5e:
undetectable		 6dj1B-5gw5e:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON
(Saccharomyces
cerevisiae) 		5 / 12 GLY e 317
ALA e 318
ASP e 319
GLY e 375
VAL e 363
 None
 0.97A 6dj2B-5gw5e:
undetectable		 6dj2B-5gw5e:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 TYR z 386
ASP z 163
VAL z 162
ALA q  88
 None
 0.91A 6djzB-5gw5z:
undetectable		 6djzB-5gw5z:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		5 / 11 VAL d 285
ALA d 232
LEU d 215
THR d 364
ALA d 347
 None
 1.45A 6dk1C-5gw5d:
undetectable		 6dk1C-5gw5d:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		5 / 10 SER d  95
LEU d 135
LEU d 447
ILE d 411
GLY d 413
 None
 1.23A 6dm0B-5gw5d:
undetectable
6dm0C-5gw5d:
undetectable		 6dm0B-5gw5d:
9.73
6dm0C-5gw5d:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		5 / 9 LEU d 103
THR d 100
ILE d 450
PHE d 443
ILE d 508
 None
 1.35A 6ebpA-5gw5d:
2.4		 6ebpA-5gw5d:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		5 / 12 LEU d 308
ILE d 241
VAL d 312
LEU d 286
ILE d 288
 None
 1.05A 6ectA-5gw5d:
undetectable		 6ectA-5gw5d:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA
(Saccharomyces
cerevisiae) 		4 / 6 TYR z 355
VAL z 214
VAL z 367
THR z 368
 None
 1.44A 6f32B-5gw5z:
undetectable		 6f32B-5gw5z:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		3 / 3 LEU d 150
LEU d 179
ARG d 147
 None
 0.70A 6fgcA-5gw5d:
undetectable		 6fgcA-5gw5d:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA
(Saccharomyces
cerevisiae) 		3 / 3 LEU d 150
LEU d 179
ARG d 147
 None
 0.68A 6fgdA-5gw5d:
2.1		 6fgdA-5gw5d:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA
(Saccharomyces
cerevisiae) 		3 / 3 LYS q 497
VAL q 509
ASP q 511
 None
 0.42A 6fgdA-5gw5q:
undetectable		 6fgdA-5gw5q:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA
(Saccharomyces
cerevisiae) 		4 / 6 LEU h 198
THR h 373
GLY h 200
ARG h 325
 None
 1.08A 6gtqB-5gw5h:
undetectable
6gtqD-5gw5h:
undetectable		 6gtqB-5gw5h:
16.05
6gtqD-5gw5h:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 ASP a  91
SER a 523
SER a 527
 None
 0.67A 6mxtA-5gw5a:
undetectable		 6mxtA-5gw5a:
22.18