SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gw8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		4 / 4 ALA A 292
GLN A  99
TYR A  54
LEU A 106
 None
 1.24A 1e6wC-5gw8A:
0.9		 1e6wC-5gw8A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		4 / 5 HIS A 242
GLU A 264
ALA A  27
HIS A  24
 None
 1.36A 1errA-5gw8A:
undetectable
1errB-5gw8A:
undetectable		 1errA-5gw8A:
21.31
1errB-5gw8A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 12 TYR A  54
GLY A 100
LEU A 106
PRO A 201
VAL A 230
 None
 1.24A 1gseA-5gw8A:
undetectable		 1gseA-5gw8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		3 / 3 ARG A 227
VAL A 224
TRP A 248
 None
 1.20A 1qw6A-5gw8A:
undetectable		 1qw6A-5gw8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		3 / 3 ARG A 227
VAL A 224
TRP A 248
 None
 1.26A 1qwcA-5gw8A:
undetectable		 1qwcA-5gw8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		3 / 3 ARG A 227
VAL A 224
TRP A 248
 None
 1.25A 1vagA-5gw8A:
undetectable		 1vagA-5gw8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 12 HIS A 221
LEU A 178
VAL A 203
LEU A 259
TYR A  38
 ACY  A 405 (-4.1A)
None
None
None
None
 1.41A 2prgB-5gw8A:
undetectable		 2prgB-5gw8A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		4 / 7 GLN A  45
LEU A  49
LEU A  64
GLY A  63
 None
 0.81A 2qqcD-5gw8A:
undetectable
2qqcE-5gw8A:
undetectable		 2qqcD-5gw8A:
16.08
2qqcE-5gw8A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		4 / 4 TYR A  62
LEU A  72
LEU A  71
HIS A  60
 None
 1.11A 2x7hB-5gw8A:
2.0		 2x7hB-5gw8A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		4 / 5 VAL A 134
VAL A 203
PHE A 211
ARG A 236
 None
 1.18A 3bjwH-5gw8A:
undetectable		 3bjwH-5gw8A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		4 / 6 VAL A 134
VAL A 203
PHE A 211
ARG A 236
 None
 1.23A 3bjwF-5gw8A:
undetectable		 3bjwF-5gw8A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 12 THR A  53
LEU A 145
ILE A 176
LEU A  71
TYR A  62
 None
 1.36A 3gwxB-5gw8A:
undetectable		 3gwxB-5gw8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		3 / 3 ASP A 183
PHE A 127
SER A 122
 None
 0.78A 3i5uB-5gw8A:
undetectable		 3i5uB-5gw8A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 12 LEU A 220
ALA A  95
GLY A 173
ALA A 174
LEU A 200
 None
 1.08A 3ln1A-5gw8A:
undetectable		 3ln1A-5gw8A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 12 LEU A 220
ALA A  95
GLY A 173
ALA A 174
LEU A 200
 None
 1.07A 3ln1B-5gw8A:
undetectable		 3ln1B-5gw8A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 12 LEU A 220
ALA A  95
GLY A 173
ALA A 174
LEU A 200
 None
 1.08A 3ln1D-5gw8A:
undetectable		 3ln1D-5gw8A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 12 ALA A 174
GLY A 173
ALA A  47
HIS A 221
LEU A 220
 None
None
None
ACY  A 405 (-4.1A)
None
 1.08A 3qxyA-5gw8A:
undetectable		 3qxyA-5gw8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 12 ALA A 174
GLY A 173
ALA A  47
HIS A 221
LEU A 220
 None
None
None
ACY  A 405 (-4.1A)
None
 1.08A 3rc0B-5gw8A:
undetectable		 3rc0B-5gw8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 12 VAL A 230
HIS A 281
ASP A 228
GLY A 100
SER A 171
 None
 0.97A 3sufB-5gw8A:
undetectable		 3sufB-5gw8A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		4 / 6 LEU A 179
PHE A 208
ALA A 209
LEU A 200
 None
 0.89A 3t3zA-5gw8A:
undetectable		 3t3zA-5gw8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		4 / 6 LEU A 179
PHE A 208
ALA A 209
LEU A 200
 None
 0.92A 3t3zB-5gw8A:
undetectable		 3t3zB-5gw8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		4 / 6 LEU A 179
PHE A 208
ALA A 209
LEU A 200
 None
 0.94A 3t3zD-5gw8A:
undetectable		 3t3zD-5gw8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 12 ALA A  47
SER A  44
GLY A 302
ALA A 252
GLY A 283
 None
None
None
NAG  A 402 ( 3.7A)
NAG  A 402 ( 4.0A)
 1.30A 4r29A-5gw8A:
undetectable		 4r29A-5gw8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		4 / 6 LEU A 200
TYR A 246
PRO A 231
GLU A 264
 None
 1.32A 4z4gA-5gw8A:
undetectable		 4z4gA-5gw8A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 12 SER A 293
HIS A 170
GLY A 291
HIS A 281
ASP A 228
 NAG  A 403 (-3.4A)
None
None
None
None
 1.46A 5eeiA-5gw8A:
undetectable		 5eeiA-5gw8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 12 PHE A  43
TYR A  54
ILE A  98
GLY A 169
ILE A 168
 None
 1.22A 5ifuA-5gw8A:
undetectable		 5ifuA-5gw8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		4 / 7 LEU A 178
THR A 232
ASP A 228
LEU A 220
 None
 1.04A 5jq7B-5gw8A:
undetectable		 5jq7B-5gw8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 10 ALA A  69
THR A  70
GLY A  93
ALA A  95
THR A 166
 None
 1.00A 5lf3H-5gw8A:
undetectable
5lf3I-5gw8A:
undetectable		 5lf3H-5gw8A:
21.69
5lf3I-5gw8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 10 ALA A  69
THR A  70
GLY A  93
ALA A  95
THR A 166
 None
 1.01A 5lf3V-5gw8A:
undetectable
5lf3W-5gw8A:
undetectable		 5lf3V-5gw8A:
21.69
5lf3W-5gw8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 11 ALA A  69
THR A  70
GLY A  93
ALA A  95
THR A 166
 None
 1.01A 5lf7H-5gw8A:
undetectable
5lf7I-5gw8A:
undetectable		 5lf7H-5gw8A:
21.69
5lf7I-5gw8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)
(Malassezia
globosa) 		5 / 11 ALA A  69
THR A  70
GLY A  93
ALA A  95
THR A 166
 None
 1.02A 5lf7V-5gw8A:
undetectable
5lf7W-5gw8A:
undetectable		 5lf7V-5gw8A:
21.69
5lf7W-5gw8A:
22.00