SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 THR A 197
THR A 199
PRO A 196
 None
 0.83A 1dscC-5gweA:
undetectable		 1dscC-5gweA:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 9 CYH A 403
HIS A 143
LEU A 135
LEU A 285
LEU A 289
 HEM  A 501 (-2.3A)
HEM  A 501 (-3.9A)
HEM  A 501 ( 3.9A)
None
None
 1.38A 1hwiA-5gweA:
undetectable		 1hwiA-5gweA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		4 / 7 VAL A 420
VAL A 329
ILE A 415
LEU A 333
 None
 0.92A 1iepB-5gweA:
undetectable		 1iepB-5gweA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ALA A 238
HIS A 239
VAL A 242
 None
 0.31A 1lqtB-5gweA:
undetectable		 1lqtB-5gweA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ALA A 238
HIS A 239
VAL A 242
 None
 0.32A 1lquB-5gweA:
undetectable		 1lquB-5gweA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 12 LEU A 365
ALA A 109
GLN A 110
MET A 367
THR A  97
 None
None
GWM  A 502 (-3.4A)
None
None
 1.48A 1ya3B-5gweA:
undetectable		 1ya3B-5gweA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ARG A 438
THR A 299
VAL A 445
 None
 0.84A 2qakA-5gweA:
undetectable		 2qakA-5gweA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		4 / 7 LEU A  71
ILE A  83
MET A  78
ARG A  82
 None
 1.06A 2qqcG-5gweA:
undetectable
2qqcJ-5gweA:
undetectable		 2qqcG-5gweA:
9.60
2qqcJ-5gweA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ALA A 292
THR A 296
CYH A 403
 GWM  A 502 ( 3.6A)
HEM  A 501 (-3.6A)
HEM  A 501 (-2.3A)
 0.48A 3e4eA-5gweA:
31.8		 3e4eA-5gweA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ALA A 292
THR A 296
CYH A 403
 GWM  A 502 ( 3.6A)
HEM  A 501 (-3.6A)
HEM  A 501 (-2.3A)
 0.34A 3e4eB-5gweA:
31.9		 3e4eB-5gweA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 12 ASN A 440
THR A 225
VAL A 340
ILE A 339
THR A 299
 None
None
None
HEM  A 501 (-4.3A)
None
 1.02A 3elzC-5gweA:
undetectable		 3elzC-5gweA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		4 / 7 SER A 136
LEU A 263
ARG A 147
ILE A 146
 GWM  A 502 ( 2.5A)
None
HEM  A 501 ( 3.8A)
None
 1.07A 3ln1C-5gweA:
0.9		 3ln1C-5gweA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		4 / 6 LEU A 408
ALA A 413
LEU A 300
THR A 297
 HEM  A 501 ( 4.7A)
None
HEM  A 501 ( 4.7A)
HEM  A 501 (-3.6A)
 1.04A 3rozA-5gweA:
undetectable		 3rozA-5gweA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 12 LEU A 411
LEU A 263
LEU A 203
ALA A 150
ALA A 153
 None
 1.15A 3vw7A-5gweA:
1.5		 3vw7A-5gweA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		4 / 5 ILE A 325
PRO A 326
HIS A 393
VAL A 307
 None
 1.25A 4s0vA-5gweA:
undetectable		 4s0vA-5gweA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 10 GLY A 341
ASN A 440
PRO A  58
LEU A 366
LEU A 364
 None
 1.15A 4xj7A-5gweA:
undetectable
4xj7B-5gweA:
undetectable		 4xj7A-5gweA:
21.88
4xj7B-5gweA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		4 / 7 VAL A 420
TRP A 453
LEU A 427
SER A 426
 None
 0.98A 4zphA-5gweA:
undetectable
4zphB-5gweA:
undetectable		 4zphA-5gweA:
24.02
4zphB-5gweA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 12 ALA A 409
GLY A 405
LEU A 411
ALA A 413
PRO A 326
 HEM  A 501 (-3.2A)
HEM  A 501 (-3.5A)
None
None
None
 0.90A 5jglB-5gweA:
undetectable		 5jglB-5gweA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ARG A 444
PRO A 446
TYR A 335
 SO4  A 503 (-3.1A)
None
SO4  A 503 (-4.0A)
 0.99A 5tzoB-5gweA:
undetectable		 5tzoB-5gweA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 12 SER A 136
GLY A 227
PHE A 291
ALA A 292
THR A 296
 GWM  A 502 ( 2.5A)
None
GWM  A 502 (-4.7A)
GWM  A 502 ( 3.6A)
HEM  A 501 (-3.6A)
 0.77A 5veuH-5gweA:
29.4		 5veuH-5gweA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ARG A 306
PHE A  65
ARG A 444
 SO4  A 503 (-2.7A)
SO4  A 503 (-4.4A)
SO4  A 503 (-3.1A)
 0.87A 5y9yA-5gweA:
undetectable		 5y9yA-5gweA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5gwe CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 GLY A  55
VAL A  87
MET A  78
 None
 0.65A 5ycpA-5gweA:
undetectable		 5ycpA-5gweA:
10.54