SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gwj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 7 LEU A 489
SER A 487
LEU A 484
ALA A 637
 None
 0.77A 1j8uA-5gwjA:
undetectable		 1j8uA-5gwjA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AM9_A_TESA1000_1
(ANDROGEN RECEPTOR)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 12 ASN A 798
LEU A 787
GLN A 742
MET A 863
LEU A 833
 None
 1.39A 2am9A-5gwjA:
undetectable		 2am9A-5gwjA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 9 ILE A 872
ILE A 731
ASP A 726
GLY A 875
ALA A 877
 None
 1.35A 2dtjA-5gwjA:
undetectable
2dtjB-5gwjA:
undetectable		 2dtjA-5gwjA:
13.43
2dtjB-5gwjA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 6 LEU A 826
GLN A 801
LEU A 746
PHE A 834
 None
 1.12A 2einP-5gwjA:
2.2
2einW-5gwjA:
undetectable		 2einP-5gwjA:
15.12
2einW-5gwjA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 5 LEU A1184
ALA A1186
LEU A 832
MET A 863
 None
 1.04A 2oaxA-5gwjA:
undetectable		 2oaxA-5gwjA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 8 ASN A 576
PHE A 572
TYR A 538
ASN A 524
 None
 1.26A 2wekB-5gwjA:
undetectable		 2wekB-5gwjA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 6 TYR A 923
PRO A 881
ILE A1034
ASN A 921
 None
 1.26A 2wekB-5gwjA:
undetectable		 2wekB-5gwjA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 12 THR A 808
ASN A 786
GLY A 813
ALA A 816
GLN A 805
 None
MG  A1304 ( 4.8A)
None
None
None
 1.19A 2x2iA-5gwjA:
undetectable		 2x2iA-5gwjA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 11 SER A 766
THR A 748
ALA A 768
GLY A 765
ALA A 764
 None
 1.30A 2xh9A-5gwjA:
undetectable		 2xh9A-5gwjA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		3 / 3 THR A1012
SER A1015
LYS A1027
 None
 1.12A 3aocC-5gwjA:
2.1		 3aocC-5gwjA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 12 GLY A 531
LEU A 532
LEU A 507
ASN A 525
VAL A 530
 None
 1.10A 3av6A-5gwjA:
undetectable		 3av6A-5gwjA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 12 GLY A 567
PHE A 722
ASP A 561
ILE A 565
LEU A 568
 None
 1.21A 3iv6D-5gwjA:
undetectable		 3iv6D-5gwjA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 12 GLU A 477
ILE A 565
SER A 563
GLU A 718
GLU A 588
 MG  A1303 ( 4.3A)
None
None
None
None
 1.03A 3r75A-5gwjA:
2.2		 3r75A-5gwjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 12 GLU A 477
ILE A 565
SER A 563
GLU A 718
GLU A 588
 MG  A1303 ( 4.3A)
None
None
None
None
 1.02A 3r75B-5gwjA:
2.2		 3r75B-5gwjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 11 GLU A 477
ILE A 565
SER A 563
GLU A 718
GLU A 588
 MG  A1303 ( 4.3A)
None
None
None
None
 1.02A 3r76A-5gwjA:
2.0		 3r76A-5gwjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 11 GLU A 477
ILE A 565
SER A 563
GLU A 718
GLU A 588
 MG  A1303 ( 4.3A)
None
None
None
None
 1.04A 3r76B-5gwjA:
2.1		 3r76B-5gwjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 7 GLY A 464
ALA A 463
ASP A 495
ARG A 496
 None
 0.85A 3ur0B-5gwjA:
undetectable		 3ur0B-5gwjA:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 7 ARG A 503
GLY A 504
ILE A 506
ASN A 520
 N2S  A1301 ( 3.9A)
N2W  A1302 ( 4.4A)
None
None
 1.00A 4g0vA-5gwjA:
53.7		 4g0vA-5gwjA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 6 ARG A 503
GLY A 504
ASN A 520
GLN A 778
 N2S  A1301 ( 3.9A)
N2W  A1302 ( 4.4A)
None
N2W  A1302 ( 2.7A)
 1.05A 4g0vB-5gwjA:
52.9		 4g0vB-5gwjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 7 GLY A 478
ASP A 479
GLY A 504
GLU A 522
 N2W  A1302 ( 3.0A)
N2W  A1302 ( 3.4A)
N2W  A1302 ( 4.4A)
None
 0.78A 4koeA-5gwjA:
8.6
4koeB-5gwjA:
31.1
4koeD-5gwjA:
19.9		 4koeA-5gwjA:
21.86
4koeB-5gwjA:
21.86
4koeD-5gwjA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		3 / 3 ARG A 729
GLU A 728
PHE A1019
 None
 0.93A 4kszA-5gwjA:
undetectable		 4kszA-5gwjA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 8 GLU A 718
ILE A 590
GLN A 558
ILE A 593
 None
 0.86A 4mj8A-5gwjA:
undetectable		 4mj8A-5gwjA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 12 GLY A 813
ALA A 816
ASN A 798
ASN A 795
SER A 794
 None
None
None
MG  A1304 ( 4.8A)
None
 1.36A 4pb1A-5gwjA:
2.5		 4pb1A-5gwjA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 12 PHE A 585
GLY A 550
ILE A 552
LEU A 532
ILE A 523
 None
 0.99A 4pd4C-5gwjA:
2.1		 4pd4C-5gwjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 12 LEU A 568
SER A 670
PHE A 669
GLY A 567
GLY A 562
 None
 0.98A 4rzvA-5gwjA:
undetectable		 4rzvA-5gwjA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 5 GLY A 478
ARG A 503
GLY A 504
GLU A 522
 N2W  A1302 ( 3.0A)
N2S  A1301 ( 3.9A)
N2W  A1302 ( 4.4A)
None
 0.95A 4z2eB-5gwjA:
30.2
4z2eC-5gwjA:
20.0		 4z2eB-5gwjA:
21.10
4z2eC-5gwjA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 7 GLY A 478
ASP A 479
GLY A 504
GLU A 522
 N2W  A1302 ( 3.0A)
N2W  A1302 ( 3.4A)
N2W  A1302 ( 4.4A)
None
 0.82A 4z53A-5gwjA:
31.1
4z53B-5gwjA:
31.3		 4z53A-5gwjA:
28.42
4z53B-5gwjA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 6 GLY A 478
ASP A 479
ARG A 503
GLY A 504
 N2W  A1302 ( 3.0A)
N2W  A1302 ( 3.4A)
N2S  A1301 ( 3.9A)
N2W  A1302 ( 4.4A)
 0.67A 5cdnR-5gwjA:
30.8
5cdnS-5gwjA:
20.4		 5cdnR-5gwjA:
21.66
5cdnS-5gwjA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 12 LEU A 653
LEU A 475
PHE A 585
THR A 472
LEU A 532
 None
 1.18A 5iepA-5gwjA:
undetectable		 5iepA-5gwjA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 10 TYR A 534
ILE A 523
ILE A 526
VAL A 509
ILE A 573
 None
 1.26A 5mvnD-5gwjA:
undetectable		 5mvnD-5gwjA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 10 TYR A 534
ILE A 523
ILE A 526
VAL A 509
ILE A 573
 None
 1.29A 5mzrA-5gwjA:
1.1		 5mzrA-5gwjA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 10 TYR A 534
ILE A 523
ILE A 526
VAL A 509
ILE A 573
 None
 1.29A 5mzrC-5gwjA:
1.1		 5mzrC-5gwjA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 12 LEU A 586
GLY A 550
ILE A 529
GLY A 531
ILE A 552
 None
 1.03A 6dh3B-5gwjA:
undetectable		 6dh3B-5gwjA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 12 LEU A 586
GLY A 550
ILE A 529
GLY A 531
ILE A 552
 None
 0.99A 6dh6B-5gwjA:
undetectable		 6dh6B-5gwjA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 6 ILE A 861
LEU A1191
VAL A 889
ARG A 886
 None
 1.17A 6f6jA-5gwjA:
undetectable		 6f6jA-5gwjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		5 / 10 ALA A 999
VAL A1004
PHE A1005
ILE A 970
THR A 989
 None
 1.36A 6h1lA-5gwjA:
undetectable		 6h1lA-5gwjA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens) 		4 / 5 ARG A 831
LEU A 826
GLN A 801
PHE A 834
 None
 1.35A 6nmpP-5gwjA:
2.2
6nmpW-5gwjA:
undetectable		 6nmpP-5gwjA:
15.12
6nmpW-5gwjA:
6.46