SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gwn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		5 / 11 MET A 267
SER A 277
ARG A 311
ILE A 314
ALA A 313
 None
 1.49A 1jb0B-5gwnA:
undetectable		 1jb0B-5gwnA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		5 / 9 GLY A 383
GLY A 403
SER A 400
GLU A 401
ARG A 384
 None
 1.33A 1jhoA-5gwnA:
undetectable		 1jhoA-5gwnA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		5 / 9 GLY A 383
GLY A 403
SER A 400
GLU A 401
ARG A 384
 None
 1.25A 1jhyA-5gwnA:
undetectable		 1jhyA-5gwnA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		5 / 9 GLY A 383
GLY A 403
SER A 400
GLU A 401
ARG A 384
 None
 1.29A 1l4nA-5gwnA:
undetectable		 1l4nA-5gwnA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		5 / 9 GLY A 383
GLY A 403
SER A 400
GLU A 401
ARG A 384
 None
 1.31A 1l5kA-5gwnA:
undetectable		 1l5kA-5gwnA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		5 / 9 GLY A 383
GLY A 403
SER A 400
GLU A 401
ARG A 384
 None
 1.32A 1l5lA-5gwnA:
undetectable		 1l5lA-5gwnA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		5 / 12 GLY A 492
ILE A 108
PHE A 109
TYR A 517
GLN A 134
 None
 1.22A 1oltA-5gwnA:
undetectable		 1oltA-5gwnA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		5 / 12 SER A 417
SER A 353
VAL A 351
VAL A 376
HIS A 364
 None
 1.06A 1x70B-5gwnA:
undetectable		 1x70B-5gwnA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		5 / 6 GLY A 465
GLY A 463
GLY A 460
GLY A 138
GLY A 110
 None
 0.80A 3bogA-5gwnA:
undetectable
3bogC-5gwnA:
undetectable		 3bogA-5gwnA:
undetectable
3bogC-5gwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		4 / 4 GLY A 465
GLY A 463
GLY A 460
GLY A 138
 None
 0.67A 3bogC-5gwnA:
undetectable		 3bogC-5gwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		4 / 4 GLY A 465
GLY A 463
GLY A 460
GLY A 138
 None
 0.60A 3bogD-5gwnA:
undetectable		 3bogD-5gwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		4 / 6 LEU A 132
GLU A 191
PRO A 519
ARG A 189
 None
 1.34A 3ltwA-5gwnA:
undetectable		 3ltwA-5gwnA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		5 / 11 MET A 267
SER A 277
ARG A 311
ILE A 314
ALA A 313
 None
 1.49A 3pcqB-5gwnA:
undetectable		 3pcqB-5gwnA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		3 / 3 ASP A 369
GLY A 358
TYR A 283
 None
 0.80A 3w9tC-5gwnA:
undetectable		 3w9tC-5gwnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		3 / 3 ASP A 369
GLY A 358
TYR A 283
 None
 0.80A 3w9tG-5gwnA:
undetectable		 3w9tG-5gwnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		4 / 5 GLY A 183
ILE A 196
VAL A 190
SER A 173
 None
 1.20A 4d33A-5gwnA:
undetectable		 4d33A-5gwnA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		4 / 5 GLY A 183
ILE A 196
VAL A 190
SER A 173
 None
 1.24A 4d33B-5gwnA:
undetectable		 4d33B-5gwnA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		5 / 9 MET A 267
SER A 277
ARG A 311
ILE A 314
ALA A 313
 None
 1.43A 4fe1B-5gwnA:
undetectable		 4fe1B-5gwnA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		5 / 11 VAL A 478
TYR A 464
GLY A 110
PHE A 109
GLY A 465
 None
 1.30A 4mm9A-5gwnA:
undetectable		 4mm9A-5gwnA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		5 / 12 ALA A 111
SER A 494
GLY A 492
GLU A 178
GLY A 175
 None
 1.04A 4r29B-5gwnA:
undetectable		 4r29B-5gwnA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		4 / 6 GLU A 264
GLY A 185
ASP A 186
GLY A 183
 None
None
SO4  A 603 (-4.4A)
None
 0.87A 5cdnR-5gwnA:
undetectable
5cdnS-5gwnA:
undetectable		 5cdnR-5gwnA:
22.07
5cdnS-5gwnA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		4 / 6 GLU A 264
GLY A 185
ASP A 186
GLY A 183
 None
None
SO4  A 603 (-4.4A)
None
 0.82A 5cdnC-5gwnA:
undetectable
5cdnD-5gwnA:
undetectable		 5cdnC-5gwnA:
22.07
5cdnD-5gwnA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		4 / 6 GLU A 264
GLY A 185
ASP A 186
GLY A 183
 None
None
SO4  A 603 (-4.4A)
None
 0.85A 5cdnT-5gwnA:
undetectable
5cdnU-5gwnA:
undetectable		 5cdnT-5gwnA:
22.07
5cdnU-5gwnA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		4 / 5 ALA A 146
PRO A 193
GLY A 180
LEU A 171
 None
 1.00A 5eslA-5gwnA:
undetectable		 5eslA-5gwnA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		5 / 10 MET A 267
SER A 277
ARG A 311
ILE A 314
ALA A 313
 None
 1.44A 5oy0b-5gwnA:
undetectable		 5oy0b-5gwnA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		4 / 7 SER A 434
ALA A 490
ILE A 108
LEU A 106
 None
 1.05A 5te8A-5gwnA:
undetectable		 5te8A-5gwnA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		5 / 12 ALA A 386
GLY A 383
ILE A 389
GLY A 363
ASP A 380
 None
 0.96A 5wwsB-5gwnA:
undetectable		 5wwsB-5gwnA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		4 / 5 VAL A 332
LEU A 275
HIS A 288
THR A 342
 None
 1.43A 6dyoA-5gwnA:
undetectable		 6dyoA-5gwnA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5gwn PROTEIN RCC2
(Homo
sapiens) 		4 / 8 GLY A 279
LEU A 234
GLY A 235
GLU A 228
 None
 0.55A 6mdqA-5gwnA:
undetectable		 6mdqA-5gwnA:
10.93