SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 5gxb NANOBODY
(Vicugna
pacos) 		3 / 3 TRP B  36
ALA B  50
VAL B  48
 None
 0.94A 1bdwA-5gxbB:
undetectable
1bdwB-5gxbB:
undetectable		 1bdwA-5gxbB:
10.09
1bdwB-5gxbB:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 5gxb NANOBODY
(Vicugna
pacos) 		3 / 3 GLU B   6
VAL B   5
CYH B  22
 None
 1.06A 3fbxA-5gxbB:
undetectable		 3fbxA-5gxbB:
13.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5gxb NANOBODY
(Vicugna
pacos) 		6 / 12 VAL B   2
ALA B  24
MET B  34
ASN B  77
VAL B  79
ALA B  98
 None
 0.92A 3qxtA-5gxbB:
21.0		 3qxtA-5gxbB:
69.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5gxb NANOBODY
(Vicugna
pacos) 		7 / 12 VAL B   2
LEU B   4
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
 None
 1.03A 3qxtB-5gxbB:
21.1		 3qxtB-5gxbB:
69.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5gxb NANOBODY
(Vicugna
pacos) 		6 / 12 VAL B   2
ALA B  24
MET B  34
ASN B  74
VAL B  79
ALA B  98
 None
 0.89A 3qxvA-5gxbB:
20.7		 3qxvA-5gxbB:
68.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5gxb NANOBODY
(Vicugna
pacos) 		6 / 12 VAL B   2
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
 None
 1.17A 3qxvA-5gxbB:
20.7		 3qxvA-5gxbB:
68.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5gxb NANOBODY
(Vicugna
pacos) 		6 / 12 VAL B   2
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
 None
 1.10A 3qxvB-5gxbB:
20.7		 3qxvB-5gxbB:
68.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5gxb NANOBODY
(Vicugna
pacos) 		6 / 11 VAL B   2
ALA B  24
MET B  34
ASN B  74
VAL B  79
ALA B  98
 None
 0.89A 3qxvC-5gxbB:
21.0		 3qxvC-5gxbB:
68.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5gxb NANOBODY
(Vicugna
pacos) 		6 / 12 VAL B   2
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
 None
 1.09A 3qxvD-5gxbB:
20.9		 3qxvD-5gxbB:
68.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5gxb NANOBODY
(Vicugna
pacos) 		6 / 12 CYH B  22
ALA B  24
MET B  34
VAL B  79
ALA B  98
TYR B 118
 None
 0.81A 3qxvE-5gxbB:
17.4		 3qxvE-5gxbB:
68.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 5gxb NANOBODY
(Vicugna
pacos) 		3 / 3 GLY B  42
PRO B  41
ALA B  92
 None
 0.49A 4qn9B-5gxbB:
undetectable		 4qn9B-5gxbB:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5gxb NANOBODY
(Vicugna
pacos) 		5 / 12 ALA B  49
THR B 123
GLN B 124
THR B  91
TYR B  95
 None
 1.24A 5hfjG-5gxbB:
undetectable		 5hfjG-5gxbB:
18.67