SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		5 / 12 GLY A 182
ILE A 198
ALA A 158
GLY A 157
ALA A 159
 None
None
None
BR  A 401 (-3.6A)
None
 0.95A 1bx4A-5gxfA:
4.2		 1bx4A-5gxfA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		4 / 6 ALA A 134
LEU A 136
ILE A 270
CYH A 220
 None
 1.04A 1sbrA-5gxfA:
undetectable
1sbrB-5gxfA:
undetectable		 1sbrA-5gxfA:
18.98
1sbrB-5gxfA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		4 / 8 GLY A 128
THR A 129
ALA A 130
VAL A 320
 None
 0.48A 2a1hA-5gxfA:
undetectable
2a1hB-5gxfA:
undetectable		 2a1hA-5gxfA:
21.15
2a1hB-5gxfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		4 / 7 PHE A 132
GLY A 128
THR A  41
ILE A 315
 None
 1.02A 2bdmA-5gxfA:
undetectable		 2bdmA-5gxfA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		4 / 7 VAL A 324
LEU A 316
SER A  40
ASP A  67
 None
 1.06A 2hdnF-5gxfA:
undetectable
2hdnG-5gxfA:
undetectable
2hdnH-5gxfA:
2.7		 2hdnF-5gxfA:
23.86
2hdnG-5gxfA:
10.95
2hdnH-5gxfA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		4 / 7 LEU A 305
PRO A  29
VAL A  63
TRP A  98
 None
 1.37A 2hrcA-5gxfA:
undetectable		 2hrcA-5gxfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		5 / 12 THR A  89
VAL A 113
VAL A 127
GLY A 128
ALA A 124
 None
 1.16A 2x2iA-5gxfA:
undetectable		 2x2iA-5gxfA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		5 / 12 THR A  89
VAL A 113
VAL A 127
GLY A 128
ALA A 124
 None
 1.17A 2x2iC-5gxfA:
undetectable		 2x2iC-5gxfA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		4 / 8 PHE A 132
GLY A 131
VAL A 165
LEU A 296
 None
 1.11A 3bgdB-5gxfA:
5.0		 3bgdB-5gxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		5 / 6 PRO A  64
GLY A  53
GLY A  47
GLY A  51
GLY A 312
 None
 1.09A 3bogA-5gxfA:
undetectable
3bogC-5gxfA:
undetectable		 3bogA-5gxfA:
undetectable
3bogC-5gxfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		5 / 6 PRO A  64
GLY A 312
GLY A  51
GLY A  47
GLY A  53
 None
 0.92A 3bogA-5gxfA:
undetectable
3bogC-5gxfA:
undetectable		 3bogA-5gxfA:
undetectable
3bogC-5gxfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		3 / 3 GLY A 100
GLY A  94
GLY A  65
 None
 0.42A 3bogC-5gxfA:
undetectable		 3bogC-5gxfA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		5 / 12 THR A  41
GLY A 128
ASP A  67
ILE A  66
GLY A  65
 None
 1.11A 3eeyJ-5gxfA:
7.1		 3eeyJ-5gxfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		5 / 10 TYR A 189
VAL A 320
SER A 164
GLY A 161
GLY A 160
 None
 1.34A 3ixlA-5gxfA:
2.3		 3ixlA-5gxfA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		5 / 12 ASN A  43
GLY A 161
ARG A 183
LEU A 311
ILE A  66
 None
 1.49A 3mneA-5gxfA:
undetectable		 3mneA-5gxfA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		3 / 3 ASN A  43
ALA A 130
ARG A 323
 None
 0.79A 3tj7C-5gxfA:
undetectable
3tj7D-5gxfA:
undetectable		 3tj7C-5gxfA:
19.57
3tj7D-5gxfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		3 / 3 VAL A  87
GLY A  70
LYS A  85
 None
 0.71A 4k50I-5gxfA:
undetectable		 4k50I-5gxfA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		4 / 8 MET A 293
PHE A 132
THR A  89
VAL A 113
 None
 1.02A 4ltwA-5gxfA:
undetectable		 4ltwA-5gxfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		5 / 12 LEU A 253
GLY A 226
VAL A 245
ILE A 204
VAL A 180
 None
None
None
None
BR  A 401 (-4.6A)
 1.35A 4okwA-5gxfA:
undetectable		 4okwA-5gxfA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		5 / 12 LEU A 193
ALA A 223
ALA A 134
GLY A 160
GLY A 157
 None
None
None
None
BR  A 401 (-3.6A)
 1.02A 4rn6B-5gxfA:
undetectable		 4rn6B-5gxfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		4 / 6 CYH A  49
ILE A  50
ILE A  66
ASP A  67
 None
 1.21A 4w5tA-5gxfA:
undetectable		 4w5tA-5gxfA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		5 / 11 ALA A 166
THR A 167
ALA A 168
GLY A 160
GLY A 161
 None
 1.04A 5lf3Y-5gxfA:
undetectable
5lf3Z-5gxfA:
undetectable		 5lf3Y-5gxfA:
21.45
5lf3Z-5gxfA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		6 / 11 ALA A 166
THR A 167
ALA A 168
VAL A 221
GLY A 160
GLY A 161
 None
 1.23A 5lf7K-5gxfA:
undetectable
5lf7L-5gxfA:
undetectable		 5lf7K-5gxfA:
21.45
5lf7L-5gxfA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		6 / 11 ALA A 166
THR A 167
ALA A 168
VAL A 221
GLY A 160
GLY A 161
 None
 1.24A 5lf7Y-5gxfA:
undetectable
5lf7Z-5gxfA:
undetectable		 5lf7Y-5gxfA:
21.45
5lf7Z-5gxfA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		4 / 7 LEU A 141
ILE A 204
THR A 156
MET A 236
 None
 1.21A 5ljcA-5gxfA:
undetectable		 5ljcA-5gxfA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		4 / 8 THR A 156
ARG A 231
GLN A 235
TRP A 217
 None
 1.22A 5tzoA-5gxfA:
undetectable		 5tzoA-5gxfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		4 / 8 THR A 156
ARG A 231
GLN A 235
TRP A 217
 None
 1.31A 5tzoB-5gxfA:
undetectable		 5tzoB-5gxfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		4 / 8 THR A 156
ARG A 231
GLN A 235
TRP A 217
 None
 1.22A 5tzoC-5gxfA:
undetectable		 5tzoC-5gxfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		4 / 6 MET A 125
GLU A  38
GLY A 100
GLY A  99
 None
 0.81A 5x7pB-5gxfA:
undetectable		 5x7pB-5gxfA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 5gxf ACRYLYL-COA
REDUCTASE ACUI
(Ruegeria
pomeroyi) 		5 / 12 VAL A  63
GLY A  70
VAL A  86
THR A  89
GLY A  90
 None
 1.17A 6brdC-5gxfA:
undetectable		 6brdC-5gxfA:
18.75