SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gxj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 5gxj FLAVIVIRUS_NS2B,LINK
ER,PEPTIDASE S7
(Zika
virus;
synthetic
construct) 		4 / 6 GLU A  66
ILE A1139
TYR A1150
GLY A1136
 None
 0.99A 1maaB-5gxjA:
undetectable
1maaD-5gxjA:
undetectable		 1maaB-5gxjA:
18.69
1maaD-5gxjA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5gxj FLAVIVIRUS_NS2B,LINK
ER,PEPTIDASE S7
(synthetic
construct;
Zika
virus) 		4 / 5 SER A1135
GLY A1151
HIS A1047
ASP A1075
 None
 1.13A 2oxtB-5gxjA:
undetectable		 2oxtB-5gxjA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5gxj FLAVIVIRUS_NS2B,LINK
ER,PEPTIDASE S7
(synthetic
construct;
Zika
virus) 		4 / 7 MET A  51
LEU A1058
SER A1033
GLY A1133
 None
 0.94A 3hcnA-5gxjA:
undetectable		 3hcnA-5gxjA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 5gxj FLAVIVIRUS_NS2B,LINK
ER,PEPTIDASE S7
(synthetic
construct;
Zika
virus) 		4 / 6 PHE A1046
TYR A1079
THR A1053
VAL A1052
 None
 1.22A 3lb3A-5gxjA:
undetectable		 3lb3A-5gxjA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5gxj FLAVIVIRUS_NS2B,LINK
ER,PEPTIDASE S7
(Zika
virus;
synthetic
construct) 		5 / 12 HIS A1051
VAL A1072
ASP A1075
GLY A1133
SER A1135
 None
 0.81A 3sueC-5gxjA:
3.6		 3sueC-5gxjA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5gxj FLAVIVIRUS_NS2B,LINK
ER,PEPTIDASE S7
(Zika
virus;
synthetic
construct) 		5 / 12 HIS A1051
VAL A1072
ASP A1075
GLY A1133
SER A1135
 None
 0.86A 3sufD-5gxjA:
11.1		 3sufD-5gxjA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5gxj FLAVIVIRUS_NS2B,LINK
ER,PEPTIDASE S7
(Zika
virus;
synthetic
construct) 		5 / 9 ILE A1147
TRP A1083
GLN A1096
LEU A1149
LEU A1076
 None
 1.12A 5fhzB-5gxjA:
undetectable		 5fhzB-5gxjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5gxj FLAVIVIRUS_NS2B,LINK
ER,PEPTIDASE S7
(Zika
virus;
synthetic
construct) 		5 / 10 ILE A1147
TRP A1083
GLN A1096
LEU A1149
LEU A1076
 None
 1.07A 5fhzC-5gxjA:
undetectable		 5fhzC-5gxjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5gxj FLAVIVIRUS_NS2B,LINK
ER,PEPTIDASE S7
(Zika
virus;
synthetic
construct) 		4 / 6 TRP A1083
GLY A1144
ALA A1087
LEU A1085
 None
 1.00A 6fosA-5gxjA:
undetectable		 6fosA-5gxjA:
14.73