SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gxu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		4 / 7 THR A 113
THR A 167
GLY A 205
TYR A 209
 FMN  A 801 (-3.2A)
FMN  A 801 (-4.1A)
FMN  A 801 (-3.3A)
FMN  A 801 (-3.5A)
 0.82A 1bu5A-5gxuA:
18.5		 1bu5A-5gxuA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		4 / 7 THR A 115
THR A 167
GLY A 205
TYR A 209
 FMN  A 801 (-3.7A)
FMN  A 801 (-4.1A)
FMN  A 801 (-3.3A)
FMN  A 801 (-3.5A)
 0.79A 1bu5A-5gxuA:
18.5		 1bu5A-5gxuA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 12 ALA A 483
LEU A 380
PHE A 378
LEU A 403
LEU A 370
 None
 1.15A 1dtlA-5gxuA:
undetectable		 1dtlA-5gxuA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 12 LEU A 380
PHE A 378
LEU A 403
LEU A 407
PHE A 478
 None
 1.19A 1dtlA-5gxuA:
undetectable		 1dtlA-5gxuA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_1
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		4 / 4 THR A 702
GLN A 701
GLU A 694
ASP A 689
 None
 1.49A 1nw3A-5gxuA:
3.7		 1nw3A-5gxuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		3 / 3 GLU A 336
HIS A 334
HIS A 505
 None
 0.69A 1oe2A-5gxuA:
undetectable		 1oe2A-5gxuA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 12 VAL A 234
ASP A 220
ALA A 216
THR A 167
LEU A 236
 None
None
None
FMN  A 801 (-4.1A)
None
 1.06A 1r9oA-5gxuA:
undetectable		 1r9oA-5gxuA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		4 / 5 LEU A 413
LEU A 461
LEU A 369
LEU A 370
 None
 1.00A 2ab2B-5gxuA:
undetectable		 2ab2B-5gxuA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 12 LEU A 231
LEU A 258
LEU A 262
ILE A 261
THR A 106
 None
 1.07A 2bdmA-5gxuA:
3.2		 2bdmA-5gxuA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		3 / 3 MET A 529
GLU A 322
ASP A 607
 None
 1.02A 3a25A-5gxuA:
undetectable		 3a25A-5gxuA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 12 TYR A 346
VAL A 352
ILE A 546
ALA A 500
SER A 495
 None
 1.35A 3apwA-5gxuA:
undetectable		 3apwA-5gxuA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		4 / 7 ILE A 493
GLY A 353
TYR A 313
LEU A 335
 None
 0.89A 3elzA-5gxuA:
undetectable		 3elzA-5gxuA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 10 VAL A 139
ASP A 140
LEU A 155
THR A 185
LEU A 165
 None
 1.38A 3j6gB-5gxuA:
4.6		 3j6gB-5gxuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 10 VAL A 139
ASP A 140
LEU A 155
THR A 185
LEU A 165
 None
 1.38A 3j6gD-5gxuA:
4.6		 3j6gD-5gxuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 10 VAL A 139
ASP A 140
LEU A 155
THR A 185
LEU A 165
 None
 1.38A 3j6gF-5gxuA:
4.6		 3j6gF-5gxuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 10 VAL A 139
ASP A 140
LEU A 155
THR A 185
LEU A 165
 None
 1.38A 3j6gH-5gxuA:
5.2		 3j6gH-5gxuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 10 VAL A 139
ASP A 140
LEU A 155
THR A 185
LEU A 165
 None
 1.38A 3j6gJ-5gxuA:
5.5		 3j6gJ-5gxuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 10 VAL A 139
ASP A 140
LEU A 155
THR A 185
LEU A 165
 None
 1.38A 3j6gL-5gxuA:
4.0		 3j6gL-5gxuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 10 VAL A 139
ASP A 140
LEU A 155
THR A 185
LEU A 165
 None
 1.38A 3j6gN-5gxuA:
3.7		 3j6gN-5gxuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 10 VAL A 139
ASP A 140
LEU A 155
THR A 185
LEU A 165
 None
 1.38A 3j6gP-5gxuA:
4.2		 3j6gP-5gxuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 10 VAL A 139
ASP A 140
LEU A 155
THR A 185
LEU A 165
 None
 1.39A 3j6gR-5gxuA:
4.1		 3j6gR-5gxuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		4 / 4 PHE A 578
TYR A 660
VAL A 618
LEU A 626
 None
 1.36A 3keeD-5gxuA:
undetectable		 3keeD-5gxuA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		4 / 8 PHE A 478
ALA A 406
LEU A 367
LEU A 370
 None
 0.85A 4ejgB-5gxuA:
undetectable		 4ejgB-5gxuA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 11 LEU A 370
GLY A 476
PHE A 378
LEU A 403
ALA A 406
 None
 1.21A 4wnuA-5gxuA:
undetectable		 4wnuA-5gxuA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		4 / 5 LEU A 438
ALA A 424
LEU A 422
VAL A 477
 None
 1.18A 5cr1A-5gxuA:
undetectable		 5cr1A-5gxuA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		4 / 6 PHE A 398
PRO A 399
ARG A 409
THR A 405
 None
 1.28A 5ih0A-5gxuA:
undetectable		 5ih0A-5gxuA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		3 / 3 SER A 416
LEU A 369
MET A 465
 FAD  A 802 (-3.1A)
None
None
 0.83A 5ikrB-5gxuA:
undetectable		 5ikrB-5gxuA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		6 / 9 SER A 492
THR A 570
GLY A 571
ALA A 573
CYH A 664
GLY A 665
 FAD  A 802 (-3.3A)
FAD  A 802 (-3.9A)
None
FAD  A 802 ( 3.8A)
None
None
 0.45A 5vw4A-5gxuA:
30.3		 5vw4A-5gxuA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2
(Arabidopsis
thaliana) 		5 / 8 SER A 492
THR A 570
GLY A 571
CYH A 664
GLY A 665
 FAD  A 802 (-3.3A)
FAD  A 802 (-3.9A)
None
None
None
 0.45A 5vw5A-5gxuA:
30.1		 5vw5A-5gxuA:
18.29