SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gxv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		4 / 6 VAL A  10
VAL A  52
ILE A  62
ASN A 269
 None
 0.93A 1e06A-5gxvA:
undetectable		 1e06A-5gxvA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		4 / 7 SER A 116
ILE A 237
ILE A 118
THR A 247
 None
 0.93A 1sbrB-5gxvA:
undetectable		 1sbrB-5gxvA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		5 / 10 LEU A 194
LEU A 197
ILE A 163
GLU A 155
LEU A 153
 None
 1.20A 1wopA-5gxvA:
0.0		 1wopA-5gxvA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		5 / 12 ALA A 266
LEU A 282
PHE A 281
VAL A 295
GLY A  18
 None
 1.03A 2ve3A-5gxvA:
undetectable		 2ve3A-5gxvA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		4 / 8 PHE A 437
LEU A 450
VAL A 447
LEU A 446
 None
 0.88A 2w98B-5gxvA:
undetectable		 2w98B-5gxvA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		5 / 12 ILE A 110
LEU A 264
ILE A  61
VAL A  25
LEU A  22
 None
 0.99A 3a51C-5gxvA:
undetectable		 3a51C-5gxvA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		4 / 6 PRO A 128
LEU A 149
ALA A 225
PRO A 127
 None
 1.33A 3gv1A-5gxvA:
undetectable
3gv1C-5gxvA:
undetectable		 3gv1A-5gxvA:
14.10
3gv1C-5gxvA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		4 / 6 LEU A 149
ALA A 225
PRO A 127
PRO A 128
 None
 1.31A 3gv1A-5gxvA:
undetectable
3gv1B-5gxvA:
undetectable		 3gv1A-5gxvA:
14.10
3gv1B-5gxvA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		5 / 12 VAL A 345
GLY A 189
ALA A 190
LEU A 194
LEU A 162
 None
 1.02A 3hs6A-5gxvA:
undetectable		 3hs6A-5gxvA:
19.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		4 / 7 GLU A 155
TYR A 157
MET A 332
TRP A 342
 None
 0.82A 3jyrA-5gxvA:
35.6		 3jyrA-5gxvA:
85.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		5 / 10 ARG A 420
ILE A 427
ILE A 383
ILE A 380
VAL A 447
 None
 1.48A 3ohtA-5gxvA:
undetectable
3ohtB-5gxvA:
undetectable		 3ohtA-5gxvA:
21.31
3ohtB-5gxvA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		3 / 3 ILE A 432
VAL A 416
ARG A 420
 None
 0.75A 3p73A-5gxvA:
0.9		 3p73A-5gxvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		6 / 11 GLY A 302
ALA A 303
VAL A 261
GLY A 262
THR A  95
PRO A 109
 None
 1.33A 3ufnA-5gxvA:
undetectable		 3ufnA-5gxvA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		4 / 5 GLU A 310
ASP A 316
ASP A 289
ASN A 296
 None
 1.37A 3vywD-5gxvA:
undetectable		 3vywD-5gxvA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		5 / 12 ALA A 435
MET A 443
LEU A 446
ARG A 449
LEU A 419
 None
 1.18A 4j24D-5gxvA:
undetectable		 4j24D-5gxvA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		4 / 7 MET A 338
TRP A 342
TYR A 173
GLU A 330
 None
 1.46A 4r87J-5gxvA:
undetectable
4r87L-5gxvA:
undetectable		 4r87J-5gxvA:
17.69
4r87L-5gxvA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		5 / 12 GLN A  51
ALA A 271
GLY A  56
THR A  55
ALA A  54
 None
 1.18A 5l66H-5gxvA:
undetectable
5l66I-5gxvA:
undetectable		 5l66H-5gxvA:
20.18
5l66I-5gxvA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		5 / 12 GLN A  51
ALA A 271
GLY A  56
THR A  55
ALA A  54
 None
 1.18A 5l66V-5gxvA:
undetectable
5l66W-5gxvA:
undetectable		 5l66V-5gxvA:
20.18
5l66W-5gxvA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG
(Escherichia
coli;
Serratia) 		3 / 3 TYR A 157
ASN A 229
LEU A 115
 None
 0.81A 6b58A-5gxvA:
undetectable		 6b58A-5gxvA:
23.00