SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gy0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 281
LEU A 236
MET A  93
LEU A 337
CYH A 274
 None
 1.47A 1a28A-5gy0A:
undetectable		 1a28A-5gy0A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A  45
ASN A  56
TRP A  55
 None
 1.29A 1r15D-5gy0A:
undetectable		 1r15D-5gy0A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A  45
ASN A  56
TRP A  55
 None
 1.29A 1r15E-5gy0A:
undetectable		 1r15E-5gy0A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A  45
ASN A  56
TRP A  55
 None
 1.26A 1r15F-5gy0A:
undetectable		 1r15F-5gy0A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 VAL A 171
GLY A 172
VAL A 170
TRP A 229
 None
 1.14A 1tkqB-5gy0A:
undetectable		 1tkqB-5gy0A:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_1
(HYPOTHETICAL PROTEIN
PH0226)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 4 TYR A 440
ARG A 329
ASP A  79
ASP A 140
 None
BGC  A 709 ( 2.8A)
BGC  A 710 ( 4.5A)
None
 1.40A 1ve3A-5gy0A:
undetectable		 1ve3A-5gy0A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_1
(HYPOTHETICAL PROTEIN
PH0226)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 4 TYR A 440
ARG A 329
ASP A  79
ASP A 140
 None
BGC  A 709 ( 2.8A)
BGC  A 710 ( 4.5A)
None
 1.43A 1ve3B-5gy0A:
undetectable		 1ve3B-5gy0A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A 144
ARG A 390
ASP A  76
 None
 0.93A 1vptA-5gy0A:
undetectable		 1vptA-5gy0A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLN A  47
HIS A 389
ARG A 390
 None
 0.82A 1zlqA-5gy0A:
undetectable		 1zlqA-5gy0A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLY A 277
GLU A 334
PHE A 294
HIS A 298
 None
 1.02A 2ackA-5gy0A:
undetectable		 2ackA-5gy0A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 319
LEU A 328
TYR A 364
ALA A 335
ALA A 338
 None
 1.08A 2bm9A-5gy0A:
undetectable		 2bm9A-5gy0A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 319
LEU A 328
TYR A 364
ALA A 335
ALA A 338
 None
 1.05A 2bm9C-5gy0A:
undetectable		 2bm9C-5gy0A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 319
LEU A 328
TYR A 364
ALA A 335
ALA A 338
 None
 1.14A 2bm9D-5gy0A:
undetectable		 2bm9D-5gy0A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 105
PHE A 336
VAL A 445
GLY A 446
LEU A 114
 None
 1.26A 2bxeB-5gy0A:
undetectable		 2bxeB-5gy0A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 THR A 594
ASP A 514
THR A 516
ASP A 551
 None
 0.94A 2okcB-5gy0A:
undetectable		 2okcB-5gy0A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLY A 277
ALA A 278
MET A 279
LEU A 282
 None
 0.62A 2wekB-5gy0A:
undetectable		 2wekB-5gy0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 VAL A  58
HIS A 389
TYR A  75
ASN A  56
 None
 1.49A 2zs9A-5gy0A:
undetectable		 2zs9A-5gy0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 281
LEU A 236
MET A  93
LEU A 337
CYH A 274
 None
 1.36A 3d90A-5gy0A:
undetectable		 3d90A-5gy0A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ALA A 501
LEU A 503
ILE A 566
LEU A 507
PHE A 473
 None
 1.09A 3fl9E-5gy0A:
undetectable		 3fl9E-5gy0A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 VAL A 376
GLY A 412
ALA A 442
GLY A 443
LEU A 448
 None
 0.91A 3ku1A-5gy0A:
undetectable		 3ku1A-5gy0A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_A_VIBA500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ASP A 323
TRP A 325
TYR A 440
ASP A 439
GLY A 326
 None
BGC  A 709 ( 4.3A)
None
BGC  A 709 ( 4.5A)
None
 1.29A 3myuA-5gy0A:
undetectable		 3myuA-5gy0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_B_VIBB500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ASP A 323
TRP A 325
TYR A 440
ASP A 439
GLY A 326
 None
BGC  A 709 ( 4.3A)
None
BGC  A 709 ( 4.5A)
None
 1.26A 3myuB-5gy0A:
undetectable		 3myuB-5gy0A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 4 LEU A  71
GLY A  72
GLY A  50
THR A  65
 None
 0.77A 3si7A-5gy0A:
undetectable		 3si7A-5gy0A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 LEU A  71
GLY A  72
GLY A  50
THR A  65
 None
 0.79A 3si7C-5gy0A:
undetectable
3si7D-5gy0A:
undetectable		 3si7C-5gy0A:
17.65
3si7D-5gy0A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 TYR A 411
PHE A 463
PRO A 465
LEU A 460
 None
None
CL  A 705 ( 4.2A)
CL  A 705 (-3.7A)
 1.37A 3tgvB-5gy0A:
undetectable		 3tgvB-5gy0A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 TYR A 411
PHE A 463
PRO A 465
LEU A 460
 None
None
CL  A 705 ( 4.2A)
CL  A 705 (-3.7A)
 1.32A 3tgvC-5gy0A:
undetectable		 3tgvC-5gy0A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 TYR A 411
PHE A 463
PRO A 465
LEU A 460
 None
None
CL  A 705 ( 4.2A)
CL  A 705 (-3.7A)
 1.31A 3tgvD-5gy0A:
undetectable		 3tgvD-5gy0A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 609
LEU A 606
PHE A 580
TYR A 560
ILE A 558
 None
 1.29A 4claA-5gy0A:
undetectable		 4claA-5gy0A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TRP A 302
GLN A 296
THR A 303
 None
None
CL  A 703 (-4.0A)
 0.92A 4m2xA-5gy0A:
undetectable		 4m2xA-5gy0A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ALA A  36
ILE A 362
LEU A 414
PHE A 444
 None
 1.11A 4uymB-5gy0A:
undetectable		 4uymB-5gy0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 VAL A 525
ASP A 514
ASN A 595
MET A 513
ILE A 582
 None
None
CA  A 702 (-2.9A)
None
None
 1.47A 4xe0A-5gy0A:
undetectable		 4xe0A-5gy0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ASP A 430
TYR A 375
TYR A 440
LEU A 414
 None
 1.37A 5bmvB-5gy0A:
undetectable		 5bmvB-5gy0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ASN A 434
VAL A 415
ALA A 413
GLY A 378
 None
 0.93A 5fpdA-5gy0A:
undetectable		 5fpdA-5gy0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLY A  72
GLN A  48
LYS A  82
 None
 0.95A 5imsB-5gy0A:
undetectable		 5imsB-5gy0A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 511
ILE A 556
ILE A 558
ILE A 532
 None
 0.82A 5murB-5gy0A:
undetectable		 5murB-5gy0A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5gy0 GLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ALA A 413
GLY A 412
ASN A 441
CYH A 438
 None
 0.84A 6nm4A-5gy0A:
undetectable		 6nm4A-5gy0A:
15.40