SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gyg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		5 / 12 ARG A 211
ALA A 254
GLY A  69
GLY A  68
ILE A  14
 None
 1.00A 2o4kA-5gygA:
undetectable		 2o4kA-5gygA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		4 / 8 PHE A 150
ALA A 245
PHE A 252
ALA A  74
 None
 0.98A 3t3sE-5gygA:
undetectable		 3t3sE-5gygA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		4 / 7 PHE A  72
GLY A  84
THR A  75
PHE A 252
 None
 1.03A 3vnsA-5gygA:
undetectable		 3vnsA-5gygA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		4 / 4 LEU A  59
ILE A 257
GLY A  84
PHE A 252
 None
 1.10A 4dc3A-5gygA:
undetectable		 4dc3A-5gygA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		5 / 12 PHE A 150
ILE A 243
GLY A  55
ALA A  74
THR A  75
 None
 1.10A 4enhA-5gygA:
undetectable		 4enhA-5gygA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		5 / 12 GLY A 123
ILE A 216
PHE A  72
ILE A 257
PHE A 252
 None
 1.14A 4fglA-5gygA:
undetectable
4fglB-5gygA:
undetectable		 4fglA-5gygA:
20.42
4fglB-5gygA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		3 / 3 TYR A 181
PHE A 106
ARG A 207
 None
 0.96A 4g19D-5gygA:
undetectable		 4g19D-5gygA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		5 / 12 GLU A 244
TYR A 144
TYR A 121
ASP A  81
LEU A  83
 None
 1.05A 4xqeA-5gygA:
undetectable		 4xqeA-5gygA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B504_1
(HOMOSPERMIDINE
SYNTHASE)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		5 / 12 GLU A 244
TYR A 144
TYR A 121
ASP A  81
LEU A  83
 None
 1.06A 4xqeB-5gygA:
undetectable		 4xqeB-5gygA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		5 / 12 GLU A 244
TYR A 144
TYR A 121
ASP A  81
LEU A  83
 None
 1.06A 4xrgB-5gygA:
undetectable		 4xrgB-5gygA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		5 / 12 GLY A 214
PHE A 150
GLY A 248
GLY A 250
PHE A 241
 None
 1.06A 5eqbA-5gygA:
undetectable		 5eqbA-5gygA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		4 / 5 GLY A 178
PRO A 160
GLN A 208
THR A 175
 None
 1.26A 5h5fA-5gygA:
undetectable		 5h5fA-5gygA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		5 / 9 ILE A 145
GLY A 123
ILE A 122
PRO A 210
ILE A 206
 None
 1.12A 5kqxB-5gygA:
undetectable		 5kqxB-5gygA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		5 / 9 ALA A  19
ASP A  15
GLY A 105
ILE A 257
PRO A 273
 None
 1.22A 5kr2A-5gygA:
undetectable		 5kr2A-5gygA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		5 / 9 ALA A  19
ASP A  15
GLY A 105
ILE A 257
PRO A 273
 None
 1.18A 5kr2C-5gygA:
undetectable		 5kr2C-5gygA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		4 / 6 ARG A 207
PHE A 204
ILE A 163
THR A 166
 None
 1.12A 5vceA-5gygA:
undetectable		 5vceA-5gygA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		5 / 9 ALA A  70
ILE A 257
GLY A  84
PHE A  72
GLY A  87
 None
 1.17A 6awoA-5gygA:
undetectable		 6awoA-5gygA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		5 / 9 ALA A  70
ILE A 257
GLY A  84
PHE A  72
GLY A  87
 None
 1.18A 6awqA-5gygA:
undetectable		 6awqA-5gygA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 5gyg ENDO-1,4-BETA-XYLANA
SE
(termite
gut
metagenome) 		5 / 12 PRO A  16
ILE A  14
ILE A  13
THR A 272
PHE A 259
 None
 1.11A 6hlpA-5gygA:
undetectable		 6hlpA-5gygA:
18.53