SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5gyj PUTATIVE PEPTIDASE
C60B, SORTASE B
(Clostridioides
difficile) 		4 / 7 TYR A 178
THR A 186
VAL A 197
ILE A 185
 None
 0.99A 1p7rA-5gyjA:
undetectable		 1p7rA-5gyjA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5gyj PUTATIVE PEPTIDASE
C60B, SORTASE B
(Clostridioides
difficile) 		4 / 6 HIS A 221
ILE A 203
TYR A 181
ASN A 103
 None
 1.22A 4o7gB-5gyjA:
undetectable		 4o7gB-5gyjA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 5gyj PUTATIVE PEPTIDASE
C60B, SORTASE B
(Clostridioides
difficile) 		5 / 9 VAL A 161
LEU A 168
ARG A 217
LEU A 206
ILE A 112
 None
 1.34A 4ubsA-5gyjA:
undetectable		 4ubsA-5gyjA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5gyj PUTATIVE PEPTIDASE
C60B, SORTASE B
(Clostridioides
difficile) 		4 / 4 VAL A  73
LEU A 146
ASN A  55
ASP A  57
 None
 1.36A 5vcyA-5gyjA:
undetectable		 5vcyA-5gyjA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5gyj PUTATIVE PEPTIDASE
C60B, SORTASE B
(Clostridioides
difficile) 		5 / 9 LEU A 206
SER A 207
PHE A  98
VAL A  73
ILE A 113
 None
 1.30A 6ef6A-5gyjA:
undetectable		 6ef6A-5gyjA:
19.55