SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gyk MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 157
PHE A 248
SER A 212
ILE A 213
ILE A 160
 None
 1.22A 2blaA-5gykA:
undetectable		 2blaA-5gykA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5gyk MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 210
LEU A 188
VAL A 194
LEU A 122
HIS A 163
 None
 1.50A 3dzyD-5gykA:
undetectable		 3dzyD-5gykA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 5gyk MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 256
LYS A 249
LEU A 252
GLU A 255
 PEE  A 301 (-4.8A)
None
None
PEE  A 301 (-3.9A)
 1.10A 3h5gA-5gykA:
undetectable
3h5gB-5gykA:
undetectable		 3h5gA-5gykA:
10.00
3h5gB-5gykA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gyk MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 157
PHE A 248
SER A 212
ILE A 213
ILE A 160
 None
 1.29A 3um5B-5gykA:
undetectable		 3um5B-5gykA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 5gyk MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12
(Saccharomyces
cerevisiae) 		4 / 7 ASN A  25
ARG A  21
LEU A  24
GLY A 136
 None
 0.90A 4cp3A-5gykA:
undetectable
4cp3B-5gykA:
undetectable		 4cp3A-5gykA:
22.67
4cp3B-5gykA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5gyk MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12
(Saccharomyces
cerevisiae) 		4 / 8 PRO A  62
ILE A 167
THR A  60
ILE A  59
 None
 0.94A 5mzrE-5gykA:
undetectable		 5mzrE-5gykA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5gyk MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 177
PRO A 259
SER A 212
ILE A 213
VAL A 214
 None
 1.17A 6debB-5gykA:
undetectable		 6debB-5gykA:
17.52