SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5gyq SPIKE GLYCOPROTEIN
(Rousettus
bat
coronavirus
HKU9) 		4 / 6 HIS A  46
PHE A 107
LEU A  78
LEU A 153
 None
 1.17A 3bgdA-5gyqA:
undetectable		 3bgdA-5gyqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 5gyq SPIKE GLYCOPROTEIN
(Rousettus
bat
coronavirus
HKU9) 		4 / 5 VAL A  22
VAL A  23
PHE A 121
ARG A  26
 None
 0.95A 3bjwH-5gyqA:
undetectable		 3bjwH-5gyqA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 5gyq SPIKE GLYCOPROTEIN
(Rousettus
bat
coronavirus
HKU9) 		4 / 6 VAL A  22
VAL A  23
PHE A 121
ARG A  26
 None
 1.05A 3bjwF-5gyqA:
undetectable		 3bjwF-5gyqA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 5gyq SPIKE GLYCOPROTEIN
(Rousettus
bat
coronavirus
HKU9) 		4 / 5 VAL A  22
VAL A  23
PHE A 121
ARG A  26
 None
 1.12A 3bjwB-5gyqA:
undetectable		 3bjwB-5gyqA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5gyq SPIKE GLYCOPROTEIN
(Rousettus
bat
coronavirus
HKU9) 		5 / 10 VAL A 167
ALA A 154
ILE A 156
LEU A 158
PHE A  36
 None
 1.05A 3fl9A-5gyqA:
undetectable		 3fl9A-5gyqA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 5gyq SPIKE GLYCOPROTEIN
(Rousettus
bat
coronavirus
HKU9) 		5 / 11 LEU A  29
TRP A  24
MET A  71
VAL A  70
ALA A 154
 None
 1.18A 3pghB-5gyqA:
undetectable		 3pghB-5gyqA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 5gyq SPIKE GLYCOPROTEIN
(Rousettus
bat
coronavirus
HKU9) 		3 / 3 ARG A 120
PHE A 121
PRO A 122
 None
 0.82A 3zoaB-5gyqA:
undetectable		 3zoaB-5gyqA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 5gyq SPIKE GLYCOPROTEIN
(Rousettus
bat
coronavirus
HKU9) 		4 / 5 THR A 157
THR A  67
ASP A  69
TYR A  94
 None
 1.42A 4oltA-5gyqA:
undetectable		 4oltA-5gyqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 5gyq SPIKE GLYCOPROTEIN
(Rousettus
bat
coronavirus
HKU9) 		4 / 5 THR A 157
THR A  67
ASP A  69
TYR A  94
 None
 1.42A 4oltB-5gyqA:
undetectable		 4oltB-5gyqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 5gyq SPIKE GLYCOPROTEIN
(Rousettus
bat
coronavirus
HKU9) 		4 / 5 THR A 157
THR A  67
ASP A  69
TYR A  94
 None
 1.43A 4qwpA-5gyqA:
undetectable		 4qwpA-5gyqA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 5gyq SPIKE GLYCOPROTEIN
(Rousettus
bat
coronavirus
HKU9) 		4 / 5 THR A 157
THR A  67
ASP A  69
TYR A  94
 None
 1.42A 4qwpB-5gyqA:
undetectable		 4qwpB-5gyqA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 5gyq SPIKE GLYCOPROTEIN
(Rousettus
bat
coronavirus
HKU9) 		4 / 7 THR A  67
ASP A  69
TYR A  94
GLY A 126
 None
 0.93A 5hwaA-5gyqA:
undetectable		 5hwaA-5gyqA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 5gyq SPIKE GLYCOPROTEIN
(Rousettus
bat
coronavirus
HKU9) 		4 / 7 THR A 157
ASP A  69
TYR A  94
GLY A 126
 None
 1.09A 5hwaA-5gyqA:
undetectable		 5hwaA-5gyqA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 5gyq SPIKE GLYCOPROTEIN
(Rousettus
bat
coronavirus
HKU9) 		3 / 3 THR A  88
HIS A  77
ASN A  80
 NAG  A 802 ( 3.9A)
NAG  A 801 (-4.3A)
None
 0.94A 5n4tA-5gyqA:
undetectable		 5n4tA-5gyqA:
21.97