SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gyz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 12 LEU A  96
ILE A 192
ALA A 193
ALA A 215
THR A 346
 None
 0.99A 1cbsA-5gyzA:
undetectable		 1cbsA-5gyzA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 10 GLY A 339
GLN A 338
VAL A 362
ILE A 434
GLY A 316
 7BV  A 500 (-3.1A)
AMP  A 501 (-4.5A)
AMP  A 501 (-4.8A)
AMP  A 501 ( 4.5A)
7BV  A 500 (-3.1A)
 1.46A 1fohC-5gyzA:
undetectable		 1fohC-5gyzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 10 GLY A 339
GLN A 338
VAL A 362
ILE A 434
GLY A 316
 7BV  A 500 (-3.1A)
AMP  A 501 (-4.5A)
AMP  A 501 (-4.8A)
AMP  A 501 ( 4.5A)
7BV  A 500 (-3.1A)
 1.46A 1fohD-5gyzA:
undetectable		 1fohD-5gyzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 9 GLY A 355
ILE A 351
GLY A 363
PRO A  11
ILE A 226
 None
7BV  A 500 (-3.1A)
None
None
None
 0.98A 1hpvA-5gyzA:
undetectable		 1hpvA-5gyzA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 8 GLY A 324
SER A 293
ILE A 312
ASP A 357
 None
 0.84A 1jg4A-5gyzA:
undetectable		 1jg4A-5gyzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 10 GLY A 339
GLN A 338
VAL A 362
ILE A 434
GLY A 316
 7BV  A 500 (-3.1A)
AMP  A 501 (-4.5A)
AMP  A 501 (-4.8A)
AMP  A 501 ( 4.5A)
7BV  A 500 (-3.1A)
 1.48A 1pn0C-5gyzA:
undetectable		 1pn0C-5gyzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 10 GLY A 339
GLN A 338
VAL A 362
ILE A 434
GLY A 316
 7BV  A 500 (-3.1A)
AMP  A 501 (-4.5A)
AMP  A 501 (-4.8A)
AMP  A 501 ( 4.5A)
7BV  A 500 (-3.1A)
 1.48A 1pn0D-5gyzA:
undetectable		 1pn0D-5gyzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 9 GLY A  23
ALA A  22
LEU A  96
PHE A 219
LEU A 194
 None
 0.99A 1y7iA-5gyzA:
3.9		 1y7iA-5gyzA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 12 LEU A  96
ILE A 192
ALA A 193
ALA A 215
THR A 346
 None
 1.04A 2fr3A-5gyzA:
undetectable		 2fr3A-5gyzA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 7 ALA A 317
GLY A 315
PHE A 292
PHE A 295
 None
7BV  A 500 ( 3.6A)
None
None
 0.97A 2wq5A-5gyzA:
undetectable		 2wq5A-5gyzA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		3 / 3 SER A 163
GLN A 162
PHE A 167
 None
 0.72A 3g4lC-5gyzA:
undetectable		 3g4lC-5gyzA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 8 LEU A 350
GLY A 394
PRO A 395
MET A 396
 None
 1.06A 3hcrA-5gyzA:
2.4		 3hcrA-5gyzA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 7 ILE A 257
LEU A  96
THR A 346
ARG A 213
 None
 1.20A 3nxuA-5gyzA:
undetectable		 3nxuA-5gyzA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 5 ILE A 397
THR A 345
THR A 346
PHE A 369
 None
 0.81A 3snfA-5gyzA:
undetectable		 3snfA-5gyzA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 7 PHE A  14
TYR A  15
ILE A 231
PRO A 225
 None
 1.12A 4g5jA-5gyzA:
undetectable		 4g5jA-5gyzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		3 / 3 SER A 347
MET A 396
ASP A 422
 7BV  A 500 (-2.3A)
None
AMP  A 501 (-2.7A)
 0.94A 4mm4B-5gyzA:
undetectable		 4mm4B-5gyzA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 12 ARG A 218
ALA A 348
GLY A 315
GLY A 248
PHE A 247
 7BV  A 500 ( 3.0A)
7BV  A 500 (-3.5A)
7BV  A 500 ( 3.6A)
None
7BV  A 500 (-4.0A)
 0.96A 4r29A-5gyzA:
undetectable		 4r29A-5gyzA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 11 GLY A 363
PHE A 432
LEU A 390
ALA A 371
PHE A 227
 None
 1.18A 4wnuA-5gyzA:
undetectable		 4wnuA-5gyzA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 7 ILE A 434
GLY A 341
THR A 345
LEU A 418
 AMP  A 501 ( 4.5A)
7BV  A 500 (-3.9A)
None
None
 0.90A 4zdzA-5gyzA:
undetectable		 4zdzA-5gyzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 7 ILE A 434
GLY A 341
THR A 345
LEU A 418
 AMP  A 501 ( 4.5A)
7BV  A 500 (-3.9A)
None
None
 0.84A 4ze3A-5gyzA:
undetectable		 4ze3A-5gyzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 7 ILE A 434
GLY A 341
THR A 345
LEU A 418
 AMP  A 501 ( 4.5A)
7BV  A 500 (-3.9A)
None
None
 0.88A 5esmA-5gyzA:
undetectable		 5esmA-5gyzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 8 ILE A 434
GLY A 341
THR A 345
LEU A 418
 AMP  A 501 ( 4.5A)
7BV  A 500 (-3.9A)
None
None
 0.84A 5hs1A-5gyzA:
undetectable		 5hs1A-5gyzA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		3 / 3 VAL A 366
SER A 347
MET A 398
 None
7BV  A 500 (-2.3A)
None
 0.84A 5ikqA-5gyzA:
undetectable		 5ikqA-5gyzA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 5gyz LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 12 GLY A 341
LEU A 287
PHE A 247
THR A 251
TYR A 255
 7BV  A 500 (-3.9A)
None
7BV  A 500 (-4.0A)
7BV  A 500 (-4.4A)
None
 1.12A 5nknA-5gyzA:
undetectable		 5nknA-5gyzA:
10.88