SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gz1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 12 LEU A 127
LEU A 130
ASN A 131
LEU A 133
LEU A 313
 None
 1.13A 1a28B-5gz1A:
undetectable		 1a28B-5gz1A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		3 / 3 GLU A 200
TYR A 172
PHE A 202
 None
 0.74A 1eqbB-5gz1A:
2.5		 1eqbB-5gz1A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		3 / 3 GLU A 200
TYR A 172
PHE A 202
 None
 0.73A 1eqbA-5gz1A:
2.6		 1eqbA-5gz1A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		3 / 3 GLU A 200
TYR A 172
PHE A 202
 None
 0.73A 1eqbD-5gz1A:
2.3		 1eqbD-5gz1A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		3 / 3 GLU A 200
TYR A 172
PHE A 202
 None
 0.74A 1eqbC-5gz1A:
2.5		 1eqbC-5gz1A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 12 LEU A 127
LEU A 130
ASN A 131
LEU A 133
LEU A 313
 None
 1.07A 1sqnA-5gz1A:
undetectable		 1sqnA-5gz1A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 12 LEU A 127
LEU A 130
ASN A 131
LEU A 133
LEU A 313
 None
 1.05A 1sqnB-5gz1A:
undetectable		 1sqnB-5gz1A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 12 LEU A 127
LEU A 130
ASN A 131
LEU A 133
LEU A 313
 None
 1.02A 1zucB-5gz1A:
undetectable		 1zucB-5gz1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 12 LEU A 130
ASN A 131
LEU A 133
LEU A 313
PHE A 269
 None
 1.21A 1zucB-5gz1A:
undetectable		 1zucB-5gz1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 12 VAL A 305
LEU A 130
THR A 146
VAL A 253
GLY A 122
 None
 1.02A 2cbrA-5gz1A:
undetectable		 2cbrA-5gz1A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		4 / 6 ALA A 117
TYR A 102
ILE A  90
ILE A 119
 None
 0.88A 2dcfA-5gz1A:
undetectable		 2dcfA-5gz1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		4 / 8 ARG A  37
PRO A 277
SER A 275
GLY A  15
 None
 1.06A 2qd3A-5gz1A:
3.1		 2qd3A-5gz1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 12 LEU A 127
LEU A 130
ASN A 131
LEU A 133
LEU A 313
 None
 1.06A 2w8yB-5gz1A:
undetectable		 2w8yB-5gz1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 12 ALA A 283
ARG A 289
ILE A   8
GLY A  15
LEU A  14
 None
 1.16A 2yjaB-5gz1A:
undetectable		 2yjaB-5gz1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		4 / 7 ALA A 117
TYR A 102
ILE A  90
ILE A 119
 None
 0.86A 2zm7A-5gz1A:
undetectable		 2zm7A-5gz1A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		4 / 8 ALA A 117
TYR A 102
ILE A  90
ILE A 119
 None
 0.87A 2zm8A-5gz1A:
undetectable		 2zm8A-5gz1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		4 / 8 ALA A 117
TYR A 102
ILE A  90
ILE A 119
 None
 0.87A 2zmaA-5gz1A:
undetectable		 2zmaA-5gz1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 12 LEU A 127
LEU A 130
ASN A 131
LEU A 133
LEU A 313
 None
 1.09A 3d90A-5gz1A:
undetectable		 3d90A-5gz1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 12 LEU A 127
LEU A 130
ASN A 131
LEU A 133
LEU A 313
 None
 1.14A 3d90B-5gz1A:
undetectable		 3d90B-5gz1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 10 ARG A  98
ASP A 307
GLY A 301
PRO A  81
ILE A 119
 None
 0.98A 3em4V-5gz1A:
undetectable		 3em4V-5gz1A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 12 ALA A 283
ARG A 289
ILE A   8
GLY A  15
LEU A  14
 None
 1.09A 3q95A-5gz1A:
undetectable		 3q95A-5gz1A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 12 ALA A 283
ARG A 289
ILE A   8
GLY A  15
LEU A  14
 None
 1.09A 3q95B-5gz1A:
undetectable		 3q95B-5gz1A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 10 VAL A 121
ALA A 302
VAL A 116
TYR A 287
ILE A  90
 None
 1.47A 3retA-5gz1A:
undetectable
3retB-5gz1A:
undetectable		 3retA-5gz1A:
15.76
3retB-5gz1A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		4 / 4 ILE A  63
VAL A  33
VAL A  31
ARG A   5
 None
 1.40A 4m6tA-5gz1A:
undetectable		 4m6tA-5gz1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 11 ALA A 283
ARG A 289
ILE A   8
GLY A  15
LEU A  14
 None
 1.12A 4pxmB-5gz1A:
undetectable		 4pxmB-5gz1A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 11 ALA A 283
ARG A 289
ILE A   8
GLY A  15
LEU A  14
 None
 1.13A 5dxbB-5gz1A:
undetectable		 5dxbB-5gz1A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 12 ALA A 283
ARG A 289
ILE A   8
GLY A  15
LEU A  14
 None
 1.10A 5gs4A-5gz1A:
undetectable		 5gs4A-5gz1A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		5 / 12 LEU A 130
ASN A 131
LEU A 133
GLY A 135
VAL A 138
 None
 0.69A 5uc1B-5gz1A:
undetectable		 5uc1B-5gz1A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		4 / 7 VAL A 180
HIS A 197
PRO A 175
ILE A 173
 None
 1.02A 5vkqA-5gz1A:
undetectable
5vkqD-5gz1A:
undetectable		 5vkqA-5gz1A:
12.38
5vkqD-5gz1A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		6 / 12 ILE A  67
MET A  66
GLY A  80
ALA A 105
ALA A  84
ALA A 110
 None
 1.41A 5zw4A-5gz1A:
undetectable		 5zw4A-5gz1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Ureibacillus
thermosphaericus) 		4 / 6 SER A  46
GLU A  29
ARG A   5
ASP A  64
 None
 1.22A 5zw4A-5gz1A:
undetectable		 5zw4A-5gz1A:
22.22