SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		3 / 3 ALA A 277
VAL A 282
TRP A 285
 None
 0.83A 1av2C-5gz4A:
undetectable
1av2D-5gz4A:
undetectable		 1av2C-5gz4A:
1.90
1av2D-5gz4A:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		3 / 3 GLU A 580
ILE A 606
ARG A 646
 None
 0.80A 1cd2A-5gz4A:
undetectable		 1cd2A-5gz4A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 7 ASP A 305
ASP A 147
TYR A 153
ARG A 150
 ZN  A 901 (-2.2A)
ZN  A 902 (-1.8A)
None
None
 1.40A 1cebA-5gz4A:
undetectable		 1cebA-5gz4A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 5 THR A 248
THR A 298
THR A 194
HIS A 237
 None
 1.31A 1d4fB-5gz4A:
undetectable		 1d4fB-5gz4A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 5 THR A 185
ASP A 305
HIS A 309
HIS A 353
HIS A 462
 ZN  A 902 (-2.7A)
ZN  A 901 (-2.2A)
ZN  A 901 (-3.1A)
ZN  A 902 (-3.0A)
ZN  A 901 (-3.2A)
 0.43A 1ei6A-5gz4A:
27.4		 1ei6A-5gz4A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		6 / 8 ASP A 147
THR A 185
ASP A 305
HIS A 309
HIS A 353
HIS A 462
 ZN  A 902 (-1.8A)
ZN  A 902 (-2.7A)
ZN  A 901 (-2.2A)
ZN  A 901 (-3.1A)
ZN  A 902 (-3.0A)
ZN  A 901 (-3.2A)
 0.50A 1ei6C-5gz4A:
27.5		 1ei6C-5gz4A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 8 THR A 185
ASP A 305
HIS A 309
HIS A 462
 ZN  A 902 (-2.7A)
ZN  A 901 (-2.2A)
ZN  A 901 (-3.1A)
ZN  A 901 (-3.2A)
 0.38A 1ei6D-5gz4A:
27.7		 1ei6D-5gz4A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 12 ALA A 325
PHE A 275
ARG A 278
LEU A 336
LEU A 167
 None
 1.16A 1eiiA-5gz4A:
0.9		 1eiiA-5gz4A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 12 ALA A 325
PHE A 275
LEU A 336
LEU A 299
LEU A 167
 None
 1.13A 1eiiA-5gz4A:
0.9		 1eiiA-5gz4A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 8 TYR A 597
SER A 620
LEU A 584
LEU A 825
 None
 0.90A 1eupA-5gz4A:
undetectable		 1eupA-5gz4A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 4 ALA A 382
VAL A 442
ALA A 381
HIS A 462
 None
None
None
ZN  A 901 (-3.2A)
 1.23A 1q23F-5gz4A:
undetectable		 1q23F-5gz4A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 7 TYR A 658
ASN A 747
LEU A 662
GLN A 659
 None
None
NAG  A 909 (-4.1A)
None
 0.73A 1qzrA-5gz4A:
undetectable		 1qzrA-5gz4A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 7 TYR A 658
ASN A 747
LEU A 662
GLN A 659
 None
None
NAG  A 909 (-4.1A)
None
 0.82A 1qzrB-5gz4A:
undetectable		 1qzrB-5gz4A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		3 / 3 ALA A 277
VAL A 282
TRP A 285
 None
 0.84A 1w5uC-5gz4A:
undetectable
1w5uD-5gz4A:
undetectable		 1w5uC-5gz4A:
1.90
1w5uD-5gz4A:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 12 GLN A 593
ASP A 736
SER A 610
PRO A 751
ILE A 613
 None
CA  A 903 (-1.9A)
None
None
None
 1.47A 1ynnC-5gz4A:
undetectable		 1ynnC-5gz4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 11 VAL A 442
TYR A 454
GLY A 380
THR A 461
ILE A 358
 None
 1.48A 2f9wA-5gz4A:
undetectable
2f9wB-5gz4A:
undetectable		 2f9wA-5gz4A:
14.59
2f9wB-5gz4A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		3 / 3 TRP A 285
ALA A 277
VAL A 282
 None
 0.83A 2izqA-5gz4A:
undetectable
2izqB-5gz4A:
undetectable		 2izqA-5gz4A:
1.90
2izqB-5gz4A:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		3 / 3 GLU A 580
GLN A 602
ARG A 646
 None
 0.94A 2w3bB-5gz4A:
2.5		 2w3bB-5gz4A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 8 THR A 489
ARG A 178
LEU A 521
GLU A 492
 None
 1.08A 2zw9A-5gz4A:
undetectable		 2zw9A-5gz4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 8 ILE A 722
ASN A 583
SER A 579
SER A 607
 None
 1.07A 2zw9B-5gz4A:
undetectable		 2zw9B-5gz4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 12 VAL A 745
ILE A 750
LEU A 669
ALA A 698
PHE A 697
 None
 1.44A 3apwB-5gz4A:
undetectable		 3apwB-5gz4A:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 5 VAL A 816
THR A 761
THR A 843
ARG A 817
 None
 1.20A 3bjwA-5gz4A:
0.9		 3bjwA-5gz4A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		3 / 3 GLY A 459
GLY A 308
GLY A 312
 None
 0.29A 3bogC-5gz4A:
undetectable		 3bogC-5gz4A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		3 / 3 GLY A 459
GLY A 308
GLY A 312
 None
 0.37A 3bogD-5gz4A:
undetectable		 3bogD-5gz4A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 8 SER A 297
LEU A 286
LEU A 341
GLY A 335
 None
 0.84A 3dcjB-5gz4A:
undetectable		 3dcjB-5gz4A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 5 TYR A 756
ILE A 750
TYR A 658
THR A 654
 None
 1.37A 3dgqA-5gz4A:
undetectable		 3dgqA-5gz4A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		6 / 12 GLY A 195
ASN A 512
ILE A 235
ASN A 493
LEU A 196
THR A 298
 None
NAG  A 912 (-1.9A)
None
None
None
None
 1.40A 3eeyC-5gz4A:
2.0		 3eeyC-5gz4A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		6 / 12 GLY A 195
ASN A 512
ILE A 235
ASN A 493
LEU A 196
THR A 298
 None
NAG  A 912 (-1.9A)
None
None
None
None
 1.42A 3eeyE-5gz4A:
undetectable		 3eeyE-5gz4A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 12 ILE A 494
GLY A 195
ILE A 192
ILE A 235
VAL A 180
 None
 0.90A 3fpjA-5gz4A:
undetectable		 3fpjA-5gz4A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 7 GLN A 810
VAL A 758
LEU A 719
LYS A 779
 None
 0.78A 3g8iA-5gz4A:
undetectable		 3g8iA-5gz4A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 5 VAL A 759
ILE A 784
TYR A 694
MET A 693
 None
 1.27A 3gvuA-5gz4A:
undetectable		 3gvuA-5gz4A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		3 / 3 ALA A 277
VAL A 282
TRP A 285
 None
 0.84A 3l8lA-5gz4A:
undetectable
3l8lB-5gz4A:
undetectable		 3l8lA-5gz4A:
1.90
3l8lB-5gz4A:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		3 / 3 HIS A 705
SER A 675
ASN A 689
 None
 0.65A 3s8pB-5gz4A:
undetectable		 3s8pB-5gz4A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 8 ASP A 147
SER A 145
ASP A 305
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
 1.14A 3sg9B-5gz4A:
undetectable		 3sg9B-5gz4A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 7 THR A 185
ASN A 206
ASP A 305
HIS A 353
 ZN  A 902 (-2.7A)
None
ZN  A 901 (-2.2A)
ZN  A 902 (-3.0A)
 0.95A 3t01A-5gz4A:
27.0		 3t01A-5gz4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 7 THR A 185
ASP A 305
HIS A 309
HIS A 462
 ZN  A 902 (-2.7A)
ZN  A 901 (-2.2A)
ZN  A 901 (-3.1A)
ZN  A 901 (-3.2A)
 0.37A 3t01A-5gz4A:
27.0		 3t01A-5gz4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		3 / 3 ARG A  58
GLU A  57
THR A  56
 None
 0.82A 3v4tA-5gz4A:
undetectable		 3v4tA-5gz4A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 8 ASP A 502
ASN A 519
THR A 843
GLY A 513
 None
 0.92A 4fo4A-5gz4A:
undetectable		 4fo4A-5gz4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		3 / 3 CYH A 501
ASN A 511
LYS A 507
 None
 1.45A 4k50A-5gz4A:
undetectable		 4k50A-5gz4A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 12 ASP A 739
SER A 610
LEU A 617
PRO A 751
ILE A 613
 None
 1.35A 4kmuC-5gz4A:
undetectable		 4kmuC-5gz4A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 12 ASP A 739
SER A 610
LEU A 617
PRO A 751
ILE A 613
 None
 1.38A 4kmuH-5gz4A:
0.9		 4kmuH-5gz4A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 11 LEU A 336
VAL A 282
LEU A 299
LEU A 341
LEU A 347
 None
 1.25A 4or0B-5gz4A:
undetectable		 4or0B-5gz4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 10 ASP A 147
TYR A 269
TYR A 300
PHE A 275
SER A 145
 ZN  A 902 (-1.8A)
None
None
None
None
 1.45A 4xpbA-5gz4A:
undetectable		 4xpbA-5gz4A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 12 LEU A 709
VAL A 721
TRP A 701
LEU A 700
LEU A 785
 None
 1.27A 4yvpB-5gz4A:
undetectable		 4yvpB-5gz4A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 10 ARG A 150
ARG A 362
LEU A 447
SER A 359
ALA A 357
 None
 1.37A 4z69I-5gz4A:
undetectable		 4z69I-5gz4A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 6 GLU A 495
GLY A 148
ASP A 147
GLY A 354
 None
ZN  A 902 ( 4.9A)
ZN  A 902 (-1.8A)
None
 0.89A 5cdnC-5gz4A:
2.6
5cdnD-5gz4A:
undetectable		 5cdnC-5gz4A:
21.20
5cdnD-5gz4A:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 6 GLU A 495
GLY A 148
ASP A 147
GLY A 354
 None
ZN  A 902 ( 4.9A)
ZN  A 902 (-1.8A)
None
 0.89A 5cdnT-5gz4A:
2.7
5cdnU-5gz4A:
undetectable		 5cdnT-5gz4A:
21.20
5cdnU-5gz4A:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		3 / 3 HIS A 705
SER A 675
ASN A 689
 None
 0.66A 5cprB-5gz4A:
undetectable		 5cprB-5gz4A:
15.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 12 ASP A 147
THR A 185
PHE A 186
HIS A 237
ARG A 278
 ZN  A 902 (-1.8A)
ZN  A 902 (-2.7A)
None
None
None
 1.42A 5dlvA-5gz4A:
52.1		 5dlvA-5gz4A:
46.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 12 ASP A 147
THR A 185
PHE A 186
PRO A 234
ARG A 278
 ZN  A 902 (-1.8A)
ZN  A 902 (-2.7A)
None
None
None
 0.80A 5dlvA-5gz4A:
52.1		 5dlvA-5gz4A:
46.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		6 / 12 ASP A 147
THR A 185
PHE A 186
PRO A 234
TRP A 236
ARG A 278
 ZN  A 902 (-1.8A)
ZN  A 902 (-2.7A)
None
None
None
None
 0.83A 5dlvB-5gz4A:
52.1		 5dlvB-5gz4A:
46.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 5 PRO A 725
LEU A 641
TYR A 670
PHE A 674
 None
 1.41A 5igjA-5gz4A:
0.3		 5igjA-5gz4A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 12 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.32A 5iqbA-5gz4A:
undetectable		 5iqbA-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_B_KANB600_1
(BIFUNCTIONAL AAC/APH)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 11 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.32A 5iqbB-5gz4A:
0.4		 5iqbB-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_C_KANC600_1
(BIFUNCTIONAL AAC/APH)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 11 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.29A 5iqbC-5gz4A:
undetectable		 5iqbC-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 12 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.30A 5iqbD-5gz4A:
undetectable		 5iqbD-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_A_51GA600_1
(BIFUNCTIONAL AAC/APH)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 10 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.08A 5iqcA-5gz4A:
0.0		 5iqcA-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_B_51GB600_1
(BIFUNCTIONAL AAC/APH)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 10 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.10A 5iqcB-5gz4A:
0.5		 5iqcB-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_D_51GD600_1
(BIFUNCTIONAL AAC/APH)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 10 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.10A 5iqcD-5gz4A:
0.1		 5iqcD-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_A_NMYA600_1
(BIFUNCTIONAL AAC/APH)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 11 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.09A 5iqeA-5gz4A:
0.0		 5iqeA-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_B_NMYB600_1
(BIFUNCTIONAL AAC/APH)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 10 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.10A 5iqeB-5gz4A:
0.0		 5iqeB-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 12 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.08A 5iqeC-5gz4A:
undetectable		 5iqeC-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 12 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.16A 5iqeD-5gz4A:
undetectable		 5iqeD-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_A_51GA600_1
(BIFUNCTIONAL AAC/APH)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 10 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.13A 5iqgA-5gz4A:
undetectable		 5iqgA-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_B_51GB600_1
(BIFUNCTIONAL AAC/APH)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 10 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.12A 5iqgB-5gz4A:
0.4		 5iqgB-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_C_51GC600_1
(BIFUNCTIONAL AAC/APH)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 10 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.10A 5iqgC-5gz4A:
0.0		 5iqgC-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_D_51GD600_1
(BIFUNCTIONAL AAC/APH)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 10 ASP A 147
SER A 145
ASP A 305
TYR A 300
GLU A 255
 ZN  A 902 (-1.8A)
None
ZN  A 901 (-2.2A)
None
None
 1.12A 5iqgD-5gz4A:
0.0		 5iqgD-5gz4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		3 / 3 TYR A 694
TYR A 729
GLN A 743
 None
 0.91A 5jsdA-5gz4A:
undetectable
5jsdB-5gz4A:
0.4		 5jsdA-5gz4A:
22.43
5jsdB-5gz4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		3 / 3 TYR A 694
TYR A 729
GLN A 743
 None
 0.91A 5jsdB-5gz4A:
undetectable
5jsdC-5gz4A:
0.4		 5jsdB-5gz4A:
22.43
5jsdC-5gz4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 4 LEU A 154
ARG A 150
ILE A 474
PHE A 149
 None
 1.15A 5kirB-5gz4A:
undetectable		 5kirB-5gz4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		3 / 3 HIS A 237
ASN A 259
ALA A 227
 None
NAG  A 905 (-1.8A)
None
 0.55A 5n4tB-5gz4A:
undetectable		 5n4tB-5gz4A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 6 PRO A 529
PRO A 525
PHE A 526
LEU A 522
 None
 1.10A 5tl8A-5gz4A:
undetectable		 5tl8A-5gz4A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		5 / 12 GLN A 593
ASP A 736
SER A 610
PRO A 751
ILE A 613
 None
CA  A 903 (-1.9A)
None
None
None
 1.46A 5uacC-5gz4A:
1.2		 5uacC-5gz4A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)
(Naja
atra) 		4 / 7 HIS A 787
THR A 665
TYR A 658
LEU A 641
 None
 1.14A 6nmfA-5gz4A:
undetectable
6nmfC-5gz4A:
undetectable
6nmfP-5gz4A:
undetectable		 6nmfA-5gz4A:
20.79
6nmfC-5gz4A:
15.54
6nmfP-5gz4A:
15.54