SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gza'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
6 / 11 GLY A  86
VAL A  93
ALA A 104
TYR A 149
SER A 154
LEU A 214
ADP  A 401 (-3.6A)
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.2A)
ADP  A 401 (-4.4A)
0.47A 2evaA-5gzaA:
20.5
2evaA-5gzaA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
6 / 12 GLY A  86
VAL A  93
ALA A 104
TYR A 149
GLY A 153
ASP A 225
ADP  A 401 (-3.6A)
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
MG  A 402 ( 1.8A)
0.77A 2wgjA-5gzaA:
18.0
2wgjA-5gzaA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
4 / 5 ARG A 176
GLN A 178
LEU A 158
PHE A 288
None
1.29A 3ablC-5gzaA:
2.6
3ablJ-5gzaA:
undetectable
3ablC-5gzaA:
21.02
3ablJ-5gzaA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
4 / 5 GLN A 212
THR A 209
THR A 277
LEU A 246
MG  A 403 (-2.6A)
None
None
None
1.36A 3ce6A-5gzaA:
undetectable
3ce6A-5gzaA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
7 / 12 GLY A  86
GLY A  88
VAL A  93
ALA A 104
VAL A 133
TYR A 149
LEU A 214
ADP  A 401 (-3.6A)
ADP  A 401 (-3.1A)
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
None
ADP  A 401 ( 4.8A)
ADP  A 401 (-4.4A)
0.49A 3fupB-5gzaA:
22.2
3fupB-5gzaA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
7 / 11 VAL A  93
ALA A 104
VAL A 133
THR A 147
TYR A 149
GLY A 153
LEU A 214
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
None
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
0.76A 3g0eA-5gzaA:
17.7
3g0eA-5gzaA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
6 / 10 VAL A  93
ALA A 104
THR A 147
TYR A 149
GLY A 153
LEU A 214
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
0.65A 3g0fB-5gzaA:
18.2
3g0fB-5gzaA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
7 / 12 VAL A  93
ALA A 104
VAL A 133
THR A 147
TYR A 149
GLY A 153
LEU A 214
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
None
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
0.48A 3g5dA-5gzaA:
20.0
3g5dA-5gzaA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
3 / 3 GLY A 137
TRP A  98
VAL A  79
None
0.75A 3n62B-5gzaA:
undetectable
3n62B-5gzaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
3 / 3 GLY A 137
TRP A  98
VAL A  79
None
0.71A 3n65B-5gzaA:
undetectable
3n65B-5gzaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
3 / 3 GLY A 137
TRP A  98
VAL A  79
None
0.73A 3n66B-5gzaA:
undetectable
3n66B-5gzaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
7 / 12 VAL A  93
ALA A 104
VAL A 133
THR A 147
TYR A 149
GLY A 153
LEU A 214
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
None
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
0.57A 3octA-5gzaA:
19.5
3octA-5gzaA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
6 / 12 ALA A 104
VAL A 133
THR A 147
TYR A 149
GLY A 153
LEU A 214
ADP  A 401 (-3.2A)
None
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
0.49A 3oezA-5gzaA:
12.7
3oezA-5gzaA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
7 / 12 VAL A  93
ALA A 104
VAL A 133
THR A 147
TYR A 149
GLY A 153
LEU A 214
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
None
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
0.52A 3qlgB-5gzaA:
13.8
3qlgB-5gzaA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
7 / 12 VAL A  93
ALA A 104
VAL A 133
THR A 147
TYR A 149
GLY A 153
LEU A 214
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
None
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
0.45A 3sxrA-5gzaA:
20.3
3sxrA-5gzaA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
7 / 12 VAL A  93
ALA A 104
VAL A 133
THR A 147
TYR A 149
GLY A 153
LEU A 214
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
None
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
0.46A 3sxrB-5gzaA:
19.9
3sxrB-5gzaA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
7 / 10 GLY A  86
GLY A  88
VAL A  93
ALA A 104
TYR A 149
SER A 154
LEU A 214
ADP  A 401 (-3.6A)
ADP  A 401 (-3.1A)
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.2A)
ADP  A 401 (-4.4A)
0.73A 4ckjA-5gzaA:
22.1
4ckjA-5gzaA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
8 / 12 VAL A  93
ALA A 104
VAL A 133
THR A 147
TYR A 149
GLY A 153
LEU A 214
ASP A 225
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
None
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
MG  A 402 ( 1.8A)
0.80A 4mxoB-5gzaA:
14.0
4mxoB-5gzaA:
29.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
7 / 12 VAL A  93
ALA A 104
VAL A 133
THR A 147
TYR A 149
GLY A 153
LEU A 214
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
None
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
0.63A 4mxxB-5gzaA:
12.7
4mxxB-5gzaA:
29.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
7 / 12 VAL A  93
VAL A 133
THR A 147
TYR A 149
GLY A 153
LEU A 214
ASP A 225
ADP  A 401 (-4.4A)
None
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
MG  A 402 ( 1.8A)
0.91A 4otwA-5gzaA:
17.2
4otwA-5gzaA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
6 / 12 ILE A  85
GLY A  86
VAL A  93
ALA A 104
TYR A 149
LEU A 214
ADP  A 401 ( 4.9A)
ADP  A 401 (-3.6A)
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 4.8A)
ADP  A 401 (-4.4A)
0.54A 4qmzA-5gzaA:
12.6
4qmzA-5gzaA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
6 / 12 ILE A  85
ALA A 104
THR A 147
TYR A 149
GLY A 153
LEU A 214
ADP  A 401 ( 4.9A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
0.57A 5i9xA-5gzaA:
19.4
5i9xA-5gzaA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
6 / 12 ILE A  85
ALA A 104
THR A 147
TYR A 149
GLY A 153
LEU A 214
ADP  A 401 ( 4.9A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.1A)
ADP  A 401 (-4.4A)
0.42A 5i9yA-5gzaA:
13.1
5i9yA-5gzaA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
6 / 12 GLY A  86
VAL A  93
ALA A 104
VAL A 133
THR A 157
LEU A 214
ADP  A 401 (-3.6A)
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
None
None
ADP  A 401 (-4.4A)
0.52A 5l2iA-5gzaA:
15.7
5l2iA-5gzaA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
4 / 4 GLN A 212
THR A 209
THR A 277
LEU A 246
MG  A 403 (-2.6A)
None
None
None
1.49A 5m5kA-5gzaA:
undetectable
5m5kA-5gzaA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
4 / 4 GLN A 212
THR A 209
THR A 277
LEU A 246
MG  A 403 (-2.6A)
None
None
None
1.50A 5m5kC-5gzaA:
undetectable
5m5kC-5gzaA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
4 / 4 GLN A 212
THR A 209
THR A 277
LEU A 246
MG  A 403 (-2.6A)
None
None
None
1.45A 5m66B-5gzaA:
undetectable
5m66B-5gzaA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
4 / 8 PRO A 283
TYR A 307
ILE A 306
VAL A 324
None
0.94A 5mzrE-5gzaA:
undetectable
5mzrE-5gzaA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
3 / 3 GLY A 137
TRP A  98
VAL A  79
None
0.74A 5vuoB-5gzaA:
undetectable
5vuoB-5gzaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
3 / 3 TYR A 183
LEU A 210
ASP A 159
None
0.75A 5zv2B-5gzaA:
18.6
5zv2B-5gzaA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
4 / 7 VAL A 155
LEU A 121
PHE A 186
LEU A 226
None
1.19A 6aycA-5gzaA:
undetectable
6aycA-5gzaA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
4 / 4 GLN A 212
THR A 209
THR A 277
LEU A 246
MG  A 403 (-2.6A)
None
None
None
1.39A 6f3mB-5gzaA:
undetectable
6f3mB-5gzaA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5gza PROTEIN O-MANNOSE
KINASE

(Danio
rerio)
4 / 6 ARG A 176
GLN A 178
LEU A 158
PHE A 288
None
1.24A 6nmpC-5gzaA:
undetectable
6nmpJ-5gzaA:
undetectable
6nmpC-5gzaA:
21.02
6nmpJ-5gzaA:
11.70