SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gzg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 12 ILE A 149
SER A 152
PRO A  24
LEU A 138
LEU A  27
 None
 1.44A 1lbcA-5gzgA:
undetectable
1lbcC-5gzgA:
undetectable		 1lbcA-5gzgA:
20.91
1lbcC-5gzgA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gzg GALECTIN-8
(Homo
sapiens) 		3 / 3 VAL A  62
ALA A  63
HIS A 128
 None
 0.70A 1q23J-5gzgA:
undetectable		 1q23J-5gzgA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gzg GALECTIN-8
(Homo
sapiens) 		4 / 7 CYH A  78
PHE A  46
PHE A  64
LEU A 138
 None
 1.05A 1qcaA-5gzgA:
undetectable		 1qcaA-5gzgA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 5gzg GALECTIN-8
(Homo
sapiens) 		4 / 8 PHE A 153
SER A 152
ILE A 105
THR A  31
 None
 0.96A 1sbrA-5gzgA:
undetectable		 1sbrA-5gzgA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 12 GLY A 139
GLY A  21
ILE A 149
SER A  54
PRO A  18
 None
 0.85A 1sg9B-5gzgA:
undetectable		 1sg9B-5gzgA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 12 GLY A 150
ASN A  10
ILE A 107
LEU A   8
THR A  31
 None
 1.07A 3eeyE-5gzgA:
undetectable		 3eeyE-5gzgA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 12 GLY A 150
ASN A  10
ILE A 107
LEU A   8
THR A  31
 None
 1.09A 3eeyJ-5gzgA:
undetectable		 3eeyJ-5gzgA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 9 GLY A 127
ASP A 112
VAL A 109
GLY A 131
ILE A 130
 None
 1.00A 3ektA-5gzgA:
undetectable		 3ektA-5gzgA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 5gzg GALECTIN-8
(Homo
sapiens) 		6 / 6 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A 201 (-3.9A)
LAT  A 201 (-4.2A)
LAT  A 201 (-2.3A)
LAT  A 201 (-3.6A)
LAT  A 201 (-3.7A)
LAT  A 201 (-3.0A)
 0.29A 3galA-5gzgA:
23.2		 3galA-5gzgA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 6 HIS A  65
ASN A  67
ARG A  45
ASN A  79
TRP A  86
 LAT  A 201 (-3.9A)
LAT  A 201 (-4.2A)
LAT  A 201 (-2.8A)
LAT  A 201 (-3.6A)
LAT  A 201 (-3.7A)
 1.43A 3galB-5gzgA:
22.9		 3galB-5gzgA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 5gzg GALECTIN-8
(Homo
sapiens) 		6 / 6 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A 201 (-3.9A)
LAT  A 201 (-4.2A)
LAT  A 201 (-2.3A)
LAT  A 201 (-3.6A)
LAT  A 201 (-3.7A)
LAT  A 201 (-3.0A)
 0.37A 3galB-5gzgA:
22.9		 3galB-5gzgA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 11 PRO A  24
LEU A 138
LEU A  27
ILE A 149
SER A 152
 None
 1.41A 3h6tA-5gzgA:
undetectable
3h6tC-5gzgA:
undetectable		 3h6tA-5gzgA:
20.91
3h6tC-5gzgA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5gzg GALECTIN-8
(Homo
sapiens) 		4 / 6 PHE A  46
VAL A 116
THR A 123
PHE A  97
 None
 1.36A 3ltwA-5gzgA:
undetectable		 3ltwA-5gzgA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A 201 (-3.9A)
NA  A 202 (-3.3A)
None
None
 1.47A 3mbhB-5gzgA:
undetectable		 3mbhB-5gzgA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A 201 (-3.9A)
NA  A 202 (-3.3A)
None
None
 1.45A 3mbhC-5gzgA:
undetectable		 3mbhC-5gzgA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A 201 (-3.9A)
NA  A 202 (-3.3A)
None
None
 1.48A 3mbhD-5gzgA:
undetectable		 3mbhD-5gzgA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 12 VAL A  62
HIS A  65
GLN A  47
VAL A  20
TYR A 141
 None
LAT  A 201 (-3.9A)
NA  A 202 (-3.3A)
None
None
 1.47A 3mbhE-5gzgA:
undetectable		 3mbhE-5gzgA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 11 LEU A  27
ALA A  63
ASP A  61
ILE A  23
ILE A 135
 None
 1.15A 3s53B-5gzgA:
undetectable		 3s53B-5gzgA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5gzg GALECTIN-8
(Homo
sapiens) 		4 / 8 ILE A  35
ILE A 149
PHE A  19
GLY A  21
 None
 0.77A 4acbC-5gzgA:
undetectable		 4acbC-5gzgA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 10 GLY A 127
ASP A 112
VAL A 109
GLY A 131
ILE A 130
 None
 0.99A 4njtB-5gzgA:
undetectable		 4njtB-5gzgA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5gzg GALECTIN-8
(Homo
sapiens) 		5 / 12 ILE A 105
ILE A  23
LEU A 138
PHE A  64
ILE A 149
 None
 1.08A 5mugA-5gzgA:
undetectable		 5mugA-5gzgA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5gzg GALECTIN-8
(Homo
sapiens) 		6 / 7 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A 201 (-3.9A)
LAT  A 201 (-4.2A)
LAT  A 201 (-2.3A)
LAT  A 201 (-3.6A)
LAT  A 201 (-3.7A)
LAT  A 201 (-3.0A)
 0.17A 6b8kA-5gzgA:
23.1		 6b8kA-5gzgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 5gzg GALECTIN-8
(Homo
sapiens) 		6 / 8 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A 201 (-3.9A)
LAT  A 201 (-4.2A)
LAT  A 201 (-2.3A)
LAT  A 201 (-3.6A)
LAT  A 201 (-3.7A)
LAT  A 201 (-3.0A)
 0.41A 6b94A-5gzgA:
18.7		 6b94A-5gzgA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 5gzg GALECTIN-8
(Homo
sapiens) 		6 / 10 HIS A  65
ASN A  67
ARG A  69
ASN A  79
TRP A  86
GLU A  89
 LAT  A 201 (-3.9A)
LAT  A 201 (-4.2A)
LAT  A 201 (-2.3A)
LAT  A 201 (-3.6A)
LAT  A 201 (-3.7A)
LAT  A 201 (-3.0A)
 0.40A 6b94A-5gzgA:
18.7
6b94B-5gzgA:
18.4		 6b94A-5gzgA:
23.17
6b94B-5gzgA:
23.17