SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gzh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 10 ALA A 221
GLY A 226
ARG A 154
LEU A 151
PRO A 424
 None
 1.37A 1cmcA-5gzhA:
undetectable
1cmcB-5gzhA:
undetectable		 1cmcA-5gzhA:
13.42
1cmcB-5gzhA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 12 GLY A 429
SER A 222
MET A 421
LEU A 277
LEU A 190
 None
 1.37A 1fm6D-5gzhA:
undetectable		 1fm6D-5gzhA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		4 / 8 LEU A 433
LEU A 213
TYR A 274
LEU A 255
 None
 1.24A 1hk2A-5gzhA:
undetectable		 1hk2A-5gzhA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 10 ARG A 154
LEU A 151
PRO A 424
ALA A 221
GLY A 226
 None
 1.35A 1mjqC-5gzhA:
undetectable
1mjqD-5gzhA:
undetectable		 1mjqC-5gzhA:
13.42
1mjqD-5gzhA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 11 ARG A 154
LEU A 151
PRO A 424
ALA A 221
GLY A 226
 None
 1.35A 1mjqI-5gzhA:
undetectable
1mjqJ-5gzhA:
undetectable		 1mjqI-5gzhA:
13.42
1mjqJ-5gzhA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		4 / 7 TYR A 122
ASN A  65
HIS A  57
TYR A  62
 None
 1.32A 1mxgA-5gzhA:
undetectable		 1mxgA-5gzhA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		3 / 3 TRP A 120
ALA A  52
VAL A  69
 None
None
IOD  A 506 ( 4.7A)
 1.00A 1w5uA-5gzhA:
undetectable
1w5uB-5gzhA:
undetectable		 1w5uA-5gzhA:
3.11
1w5uB-5gzhA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 11 GLY A  78
GLY A  85
ILE A  91
PHE A 157
VAL A 153
 None
 0.91A 2fxdA-5gzhA:
undetectable		 2fxdA-5gzhA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 11 PHE A 381
TRP A 367
ILE A 375
THR A 347
ALA A 348
 None
 1.39A 2gl0B-5gzhA:
undetectable
2gl0C-5gzhA:
undetectable		 2gl0B-5gzhA:
18.55
2gl0C-5gzhA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 12 TRP A 367
ILE A 375
THR A 347
ALA A 348
PHE A 381
 None
 1.42A 2gl0A-5gzhA:
undetectable
2gl0C-5gzhA:
undetectable		 2gl0A-5gzhA:
18.55
2gl0C-5gzhA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 12 PHE A 381
TRP A 367
ILE A 375
THR A 347
ALA A 348
 None
 1.43A 2gl0D-5gzhA:
undetectable
2gl0E-5gzhA:
undetectable		 2gl0D-5gzhA:
18.55
2gl0E-5gzhA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 11 PHE A 381
TRP A 367
ILE A 375
THR A 347
ALA A 348
 None
 1.44A 2gl0E-5gzhA:
undetectable
2gl0F-5gzhA:
undetectable		 2gl0E-5gzhA:
18.55
2gl0F-5gzhA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 11 TRP A 367
ILE A 375
THR A 347
ALA A 348
PHE A 381
 None
 1.34A 2gl0D-5gzhA:
undetectable
2gl0F-5gzhA:
undetectable		 2gl0D-5gzhA:
18.55
2gl0F-5gzhA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		3 / 3 ALA A  52
VAL A  69
TRP A 120
 None
IOD  A 506 ( 4.7A)
None
 0.97A 2izqA-5gzhA:
undetectable
2izqB-5gzhA:
undetectable		 2izqA-5gzhA:
3.11
2izqB-5gzhA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 11 SER A  75
TYR A  40
ALA A  45
GLY A  50
SER A  49
 None
 1.31A 2xf3A-5gzhA:
undetectable		 2xf3A-5gzhA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A600_1
(ORF12)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 10 SER A  75
TYR A  40
ALA A  45
GLY A  50
SER A  49
 None
 1.34A 2xfsA-5gzhA:
0.0		 2xfsA-5gzhA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 11 SER A  75
TYR A  40
ALA A  45
GLY A  50
SER A  49
 None
 1.35A 2xfsB-5gzhA:
undetectable		 2xfsB-5gzhA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		4 / 8 GLY A 226
ILE A 214
VAL A 206
SER A 222
 None
 0.76A 2yoeB-5gzhA:
1.6
2yoeC-5gzhA:
1.5		 2yoeB-5gzhA:
20.43
2yoeC-5gzhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 12 ALA A 220
GLY A 226
LEU A 218
TYR A 216
LEU A 213
 None
 1.26A 3bxoA-5gzhA:
undetectable		 3bxoA-5gzhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		6 / 10 LEU A 282
LEU A 430
VAL A 426
ILE A 214
LEU A 218
PHE A 420
 None
 1.42A 3fl9E-5gzhA:
undetectable		 3fl9E-5gzhA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 9 LEU A 282
LEU A 430
VAL A 426
ILE A 214
PHE A 420
 None
 1.18A 3freX-5gzhA:
undetectable		 3freX-5gzhA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 9 LEU A 294
THR A 356
HIS A 271
ILE A 299
LEU A 298
 None
 1.27A 3hy7B-5gzhA:
undetectable		 3hy7B-5gzhA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		3 / 3 TRP A 120
ALA A  52
VAL A  69
 None
None
IOD  A 506 ( 4.7A)
 0.93A 3l8lA-5gzhA:
undetectable
3l8lB-5gzhA:
undetectable		 3l8lA-5gzhA:
3.11
3l8lB-5gzhA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 11 ASN A 258
ILE A 217
TYR A 289
TYR A 232
ILE A 242
 None
 1.41A 3q5rA-5gzhA:
undetectable		 3q5rA-5gzhA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 12 ALA A 116
PHE A 180
GLY A  76
LEU A 151
PHE A 420
 None
 1.26A 4kykA-5gzhA:
undetectable
4kykB-5gzhA:
undetectable		 4kykA-5gzhA:
15.96
4kykB-5gzhA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		3 / 3 MET A 407
MET A 146
TYR A 274
 None
 1.29A 4p6xI-5gzhA:
undetectable		 4p6xI-5gzhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 9 GLN A 148
PHE A 145
GLY A  73
SER A  75
ILE A 399
 None
 1.39A 5entC-5gzhA:
undetectable		 5entC-5gzhA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		3 / 3 TYR A 183
SER A 181
TRP A 200
 None
None
IOD  A 509 ( 4.9A)
 1.03A 5n8jB-5gzhA:
undetectable		 5n8jB-5gzhA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		3 / 3 TYR A 183
SER A 181
TRP A 200
 None
None
IOD  A 509 ( 4.9A)
 1.03A 5n8jA-5gzhA:
undetectable		 5n8jA-5gzhA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		3 / 3 TYR A 183
SER A 181
TRP A 200
 None
None
IOD  A 509 ( 4.9A)
 1.05A 5n8jD-5gzhA:
undetectable		 5n8jD-5gzhA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		4 / 6 ILE A 147
LEU A 174
VAL A 178
ARG A 112
 None
 1.13A 6f6jA-5gzhA:
undetectable		 6f6jA-5gzhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5gzh ENDO-BETA-1,2-GLUCAN
ASE
(Chitinophaga
pinensis) 		5 / 12 GLY A 377
GLN A  36
LEU A 350
ILE A 375
TYR A  90
 None
 1.31A 6md4A-5gzhA:
undetectable		 6md4A-5gzhA:
11.50