SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gzp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5gzp TRIOSEPHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		4 / 5 GLY A 228
ILE A 221
VAL A 212
SER A 246
 None
EDO  A 305 (-4.8A)
None
None
 1.24A 1rs7A-5gzpA:
undetectable		 1rs7A-5gzpA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5gzp TRIOSEPHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		5 / 11 ILE A 204
ASP A 227
VAL A 192
ILE A 191
ILE A 188
 None
 1.19A 3kpcA-5gzpA:
undetectable		 3kpcA-5gzpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5gzp TRIOSEPHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		3 / 3 HIS A  95
GLY A 210
ILE A 170
 PGA  A 301 (-4.0A)
PGA  A 301 (-3.5A)
PGA  A 301 (-4.6A)
 0.59A 4k50A-5gzpA:
0.9		 4k50A-5gzpA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5gzp TRIOSEPHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		3 / 3 HIS A  95
GLY A 210
ILE A 170
 PGA  A 301 (-4.0A)
PGA  A 301 (-3.5A)
PGA  A 301 (-4.6A)
 0.60A 4k50I-5gzpA:
undetectable		 4k50I-5gzpA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5gzp TRIOSEPHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		4 / 6 ILE A 206
VAL A 151
PHE A 127
THR A 144
 None
 0.88A 4xe5A-5gzpA:
undetectable		 4xe5A-5gzpA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5gzp TRIOSEPHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		4 / 6 ARG A   3
ASP A 225
HIS A 185
ILE A 206
 None
 1.19A 5a06A-5gzpA:
undetectable		 5a06A-5gzpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5gzp TRIOSEPHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		5 / 11 ILE A  93
GLY A  94
PHE A   6
LEU A 113
VAL A 160
 None
 1.19A 5hw4B-5gzpA:
undetectable		 5hw4B-5gzpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 5gzp TRIOSEPHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		5 / 11 VAL A 212
SER A 211
THR A 172
TYR A 208
LEU A 220
 None
PGA  A 301 (-3.6A)
None
None
None
 1.35A 5jh7B-5gzpA:
undetectable		 5jh7B-5gzpA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5gzp TRIOSEPHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		5 / 11 VAL A 212
SER A 211
THR A 172
TYR A 208
LEU A 220
 None
PGA  A 301 (-3.6A)
None
None
None
 1.34A 5jh7D-5gzpA:
undetectable		 5jh7D-5gzpA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 5gzp TRIOSEPHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		4 / 4 ASN A 119
LEU A 121
SER A  79
LEU A  86
 None
 1.20A 5kb5A-5gzpA:
undetectable		 5kb5A-5gzpA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5gzp TRIOSEPHOSPHATE
ISOMERASE
(Plasmodium
falciparum) 		4 / 5 TYR A  90
VAL A  40
PRO A  43
ALA A   8
 None
 1.10A 5otrA-5gzpA:
undetectable		 5otrA-5gzpA:
20.73