SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		5 / 11 ALA A  54
ILE A  77
PHE A  66
ILE A 213
THR A  55
 None
 1.01A 1dyrA-5gzsA:
undetectable		 1dyrA-5gzsA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		5 / 12 ILE A 227
ILE A 213
PHE A  66
VAL A 236
LEU A 240
 None
 0.99A 1qhsA-5gzsA:
undetectable		 1qhsA-5gzsA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		5 / 12 ILE A 227
ILE A 213
PHE A  66
VAL A 236
LEU A 240
 None
 1.04A 1qhyA-5gzsA:
undetectable		 1qhyA-5gzsA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		4 / 6 ASP A 447
LEU A 360
VAL A 361
ILE A 424
 None
 0.95A 1s9qA-5gzsA:
undetectable		 1s9qA-5gzsA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		5 / 12 ILE A 213
VAL A 236
LEU A 240
ALA A  70
PHE A  66
 None
 1.37A 2jj8C-5gzsA:
undetectable		 2jj8C-5gzsA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		5 / 12 TYR A 148
ASP A 184
VAL A 183
TYR A 127
ASN A 203
 ARG  A 501 (-4.1A)
ARG  A 501 ( 4.9A)
None
None
None
 1.43A 2x0yA-5gzsA:
undetectable		 2x0yA-5gzsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		5 / 12 ALA A 185
GLU A 122
LEU A  89
TYR A 164
THR A 124
 ARG  A 501 ( 3.9A)
ARG  A 501 (-2.7A)
None
None
None
 1.12A 3fl9B-5gzsA:
undetectable		 3fl9B-5gzsA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		4 / 7 VAL A 236
ILE A 227
TYR A 230
GLN A 237
 None
 1.02A 3hgxA-5gzsA:
undetectable		 3hgxA-5gzsA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		4 / 5 ILE A 142
ARG A 109
THR A 147
GLU A 122
 None
ARG  A 501 (-3.0A)
ARG  A 501 (-4.0A)
ARG  A 501 (-2.7A)
 1.31A 3ny4A-5gzsA:
undetectable		 3ny4A-5gzsA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		5 / 12 ALA A  54
PHE A  66
LEU A 223
ILE A 213
THR A  55
 None
 1.10A 3qfxA-5gzsA:
undetectable		 3qfxA-5gzsA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		5 / 10 ALA A  54
PHE A  66
LEU A 223
ILE A 213
THR A  55
 None
 1.23A 4km0A-5gzsA:
undetectable		 4km0A-5gzsA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		4 / 5 ALA A 100
THR A  55
THR A  62
TYR A  79
 None
 1.48A 4w5oA-5gzsA:
undetectable		 4w5oA-5gzsA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		4 / 6 LEU A 256
LEU A 307
ILE A 479
PHE A 475
 None
 1.21A 4y4dA-5gzsA:
undetectable		 4y4dA-5gzsA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		4 / 6 ALA A 100
THR A  55
THR A  62
TYR A  79
 None
 1.48A 4z4cA-5gzsA:
undetectable		 4z4cA-5gzsA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		4 / 5 ALA A 100
THR A  55
THR A  62
TYR A  79
 None
 1.49A 4z4dA-5gzsA:
2.5		 4z4dA-5gzsA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		4 / 5 ALA A 100
THR A  55
THR A  62
TYR A  79
 None
 1.48A 4z4eA-5gzsA:
undetectable		 4z4eA-5gzsA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		4 / 6 TYR A 281
TYR A 353
GLU A 276
ASP A 324
 None
 1.28A 5emlA-5gzsA:
2.1		 5emlA-5gzsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		3 / 3 VAL A  90
GLU A 163
GLU A 165
 None
 0.94A 5jsdB-5gzsA:
undetectable
5jsdC-5gzsA:
undetectable		 5jsdB-5gzsA:
18.74
5jsdC-5gzsA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		3 / 3 GLY A 468
ASN A 465
ARG A 269
 None
 0.79A 5w7bD-5gzsA:
undetectable		 5w7bD-5gzsA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5gzs GGDEF FAMILY PROTEIN
(Vibrio
cholerae) 		4 / 6 PHE A 390
LEU A 393
ALA A 358
GLN A 395
 None
 0.98A 6b89B-5gzsA:
undetectable		 6b89B-5gzsA:
11.49