SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gzy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		5 / 12 PHE A 295
LEU A 216
MET A 209
ILE A 227
VAL A 177
 None
 1.15A 1hrkB-5gzyA:
undetectable		 1hrkB-5gzyA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 234
LEU A  93
LEU A 290
ILE A  86
LEU A 135
 None
 1.02A 1qzfA-5gzyA:
undetectable		 1qzfA-5gzyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 234
LEU A  93
LEU A 290
ILE A  86
LEU A 135
 None
 1.03A 1qzfB-5gzyA:
undetectable		 1qzfB-5gzyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 234
LEU A  93
LEU A 290
ILE A  86
LEU A 135
 None
 1.03A 1qzfC-5gzyA:
undetectable		 1qzfC-5gzyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 234
LEU A  93
LEU A 290
ILE A  86
LEU A 135
 None
 1.03A 1qzfD-5gzyA:
undetectable		 1qzfD-5gzyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 234
LEU A  93
LEU A 290
ILE A  86
LEU A 135
 None
 1.03A 1qzfE-5gzyA:
undetectable		 1qzfE-5gzyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		3 / 3 TRP A  67
THR A  53
TYR A 134
 None
None
2OP  A 401 ( 4.6A)
 1.23A 2a3aB-5gzyA:
undetectable		 2a3aB-5gzyA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		3 / 3 TRP A 283
LYS A 142
PRO A  15
 None
 1.26A 2dqyB-5gzyA:
undetectable		 2dqyB-5gzyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		4 / 8 ILE A 126
PHE A 127
ARG A 211
MET A 176
 None
 0.84A 2eijN-5gzyA:
0.5
2eijW-5gzyA:
undetectable		 2eijN-5gzyA:
20.49
2eijW-5gzyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		4 / 8 ILE A 126
PHE A 127
ARG A 211
MET A 176
 None
 0.88A 2eikN-5gzyA:
0.5
2eikW-5gzyA:
undetectable		 2eikN-5gzyA:
20.49
2eikW-5gzyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		4 / 8 ILE A 126
PHE A 127
ARG A 211
MET A 176
 None
 0.85A 2eilN-5gzyA:
1.3
2eilW-5gzyA:
undetectable		 2eilN-5gzyA:
20.49
2eilW-5gzyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		5 / 12 PHE A 295
LEU A 216
MET A 209
ILE A 227
VAL A 177
 None
 1.08A 2po7B-5gzyA:
undetectable		 2po7B-5gzyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		4 / 7 ILE A 126
PHE A 127
ARG A 211
MET A 176
 None
 0.85A 3ag2N-5gzyA:
undetectable
3ag2W-5gzyA:
undetectable		 3ag2N-5gzyA:
20.49
3ag2W-5gzyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		4 / 7 ILE A 126
PHE A 127
ARG A 211
MET A 176
 None
 0.92A 3ag4N-5gzyA:
1.1
3ag4W-5gzyA:
undetectable		 3ag4N-5gzyA:
20.49
3ag4W-5gzyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		4 / 5 LEU A 223
GLY A 221
GLU A 101
CYH A 226
 None
 1.13A 3aiaA-5gzyA:
undetectable
3aiaB-5gzyA:
undetectable		 3aiaA-5gzyA:
18.71
3aiaB-5gzyA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		4 / 8 ILE A 126
PHE A 127
ARG A 211
MET A 176
 None
 0.83A 3asnN-5gzyA:
1.1
3asnW-5gzyA:
undetectable		 3asnN-5gzyA:
20.49
3asnW-5gzyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		4 / 8 ALA A 122
ILE A 126
PRO A  47
PRO A 174
 None
 0.97A 3fxrA-5gzyA:
undetectable		 3fxrA-5gzyA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		5 / 12 ILE A  21
VAL A 277
ILE A 278
ILE A  52
VAL A  56
 None
None
None
2OP  A 401 (-4.0A)
None
 1.07A 3kpdC-5gzyA:
undetectable		 3kpdC-5gzyA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 234
LEU A  93
LEU A 290
ILE A  86
LEU A 135
 None
 1.03A 4ky8A-5gzyA:
undetectable		 4ky8A-5gzyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 234
LEU A  93
LEU A 290
ILE A  86
LEU A 135
 None
 1.08A 4ky8C-5gzyA:
undetectable		 4ky8C-5gzyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 234
LEU A  93
LEU A 290
ILE A  86
LEU A 135
 None
 1.07A 4ky8D-5gzyA:
undetectable		 4ky8D-5gzyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 234
LEU A  93
LEU A 290
ILE A  86
LEU A 135
 None
 1.04A 4ky8E-5gzyA:
undetectable		 4ky8E-5gzyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 234
LEU A  93
LEU A 290
ILE A  86
LEU A 135
 None
 1.08A 4q0dA-5gzyA:
undetectable		 4q0dA-5gzyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 234
LEU A  93
LEU A 290
ILE A  86
LEU A 135
 None
 1.08A 4q0dB-5gzyA:
undetectable		 4q0dB-5gzyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 234
LEU A  93
LEU A 290
ILE A  86
LEU A 135
 None
 1.08A 4q0dE-5gzyA:
undetectable		 4q0dE-5gzyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		4 / 7 ILE A 126
PHE A 127
ARG A 211
MET A 176
 None
 0.86A 5b1bN-5gzyA:
1.1
5b1bW-5gzyA:
undetectable		 5b1bN-5gzyA:
20.49
5b1bW-5gzyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		4 / 7 ILE A 126
PHE A 127
ARG A 211
MET A 176
 None
 0.83A 5b3sN-5gzyA:
undetectable
5b3sW-5gzyA:
undetectable		 5b3sN-5gzyA:
20.49
5b3sW-5gzyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		4 / 7 ILE A 126
PHE A 127
ARG A 211
MET A 176
 None
 0.85A 5iy5N-5gzyA:
1.2
5iy5W-5gzyA:
undetectable		 5iy5N-5gzyA:
20.49
5iy5W-5gzyA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		4 / 5 ALA A  82
ALA A 246
ILE A 136
LEU A 135
 None
 0.82A 5jncD-5gzyA:
undetectable		 5jncD-5gzyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		4 / 8 ILE A 126
PHE A 127
ARG A 211
MET A 176
 None
 0.83A 5xdxN-5gzyA:
1.1
5xdxW-5gzyA:
undetectable		 5xdxN-5gzyA:
20.49
5xdxW-5gzyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gzy (R)-2-HALOACID
DEHALOGENASE
(Pseudomonas
putida) 		4 / 8 ILE A 126
PHE A 127
ARG A 211
MET A 176
 None
 0.84A 5zcqN-5gzyA:
1.6
5zcqW-5gzyA:
undetectable		 5zcqN-5gzyA:
20.49
5zcqW-5gzyA:
9.60