SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h02'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		6 / 12 GLY A  69
SER A  90
MET A  93
TRP A 115
GLY A 133
SER A 135
 SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.3A)
SAH  A 301 (-3.1A)
 0.69A 1kiaA-5h02A:
20.6		 1kiaA-5h02A:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		4 / 5 ARG A  43
ASP A  88
SER A  90
SER A 135
 SAH  A 301 ( 3.2A)
SAH  A 301 (-2.8A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.1A)
 0.74A 1kiaB-5h02A:
20.8		 1kiaB-5h02A:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 GLY A  69
MET A  93
TRP A 115
GLY A 133
LEU A 139
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.3A)
None
 0.73A 1kiaC-5h02A:
21.2		 1kiaC-5h02A:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		4 / 6 ARG A  43
ASP A  88
SER A  90
SER A 135
 SAH  A 301 ( 3.2A)
SAH  A 301 (-2.8A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.1A)
 0.73A 1kiaC-5h02A:
21.2		 1kiaC-5h02A:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		6 / 12 GLY A  69
SER A  90
MET A  93
TRP A 115
SER A 135
LEU A 139
 SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.6A)
SAH  A 301 (-3.1A)
None
 0.75A 1kiaD-5h02A:
26.6		 1kiaD-5h02A:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 GLY A  69
SER A  90
MET A  93
TRP A 115
SER A 135
 SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.6A)
SAH  A 301 (-3.1A)
 0.65A 1nbhA-5h02A:
21.5		 1nbhA-5h02A:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		6 / 12 GLY A  69
SER A  90
MET A  93
TRP A 115
GLY A 133
LEU A 139
 SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.3A)
None
 0.76A 1nbhB-5h02A:
26.2		 1nbhB-5h02A:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 GLY A  69
SER A  90
MET A  93
TRP A 115
SER A 135
 SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.6A)
SAH  A 301 (-3.1A)
 0.67A 1nbhC-5h02A:
26.2		 1nbhC-5h02A:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 GLY A  69
SER A  90
MET A  93
TRP A 115
SER A 135
 SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.6A)
SAH  A 301 (-3.1A)
 0.64A 1nbhD-5h02A:
26.2		 1nbhD-5h02A:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 GLY A  69
SER A  90
TRP A 115
GLY A 133
SER A 135
 SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.3A)
SAH  A 301 (-3.1A)
 0.65A 1nbiA-5h02A:
25.8		 1nbiA-5h02A:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 GLY A  69
SER A  90
TRP A 115
GLY A 133
SER A 135
 SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.3A)
SAH  A 301 (-3.1A)
 0.65A 1nbiB-5h02A:
25.7		 1nbiB-5h02A:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		6 / 12 GLY A  69
THR A  70
ALA A  87
MET A  93
GLY A 133
SER A 135
 SAH  A 301 (-3.3A)
None
None
SAH  A 301 (-3.9A)
SAH  A 301 ( 3.3A)
SAH  A 301 (-3.1A)
 1.35A 1nbiC-5h02A:
26.0		 1nbiC-5h02A:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		7 / 12 GLY A  69
THR A  70
SER A  90
MET A  93
TRP A 115
GLY A 133
SER A 135
 SAH  A 301 (-3.3A)
None
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.3A)
SAH  A 301 (-3.1A)
 0.63A 1nbiC-5h02A:
26.0		 1nbiC-5h02A:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		6 / 12 GLY A  69
THR A  70
ALA A  87
MET A  93
GLY A 133
SER A 135
 SAH  A 301 (-3.3A)
None
None
SAH  A 301 (-3.9A)
SAH  A 301 ( 3.3A)
SAH  A 301 (-3.1A)
 1.36A 1nbiD-5h02A:
25.9		 1nbiD-5h02A:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		7 / 12 GLY A  69
THR A  70
SER A  90
MET A  93
TRP A 115
GLY A 133
SER A 135
 SAH  A 301 (-3.3A)
None
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 3.3A)
SAH  A 301 (-3.1A)
 0.64A 1nbiD-5h02A:
25.9		 1nbiD-5h02A:
30.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		6 / 12 ALA A  67
GLY A  69
SER A  90
MET A  93
SER A 135
LEU A 139
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
None
 0.79A 3bxoA-5h02A:
20.7		 3bxoA-5h02A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 GLY A  69
SER A  90
MET A  93
ARG A 116
LEU A 139
 SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.2A)
None
 0.58A 3bxoA-5h02A:
20.7		 3bxoA-5h02A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 ALA A  67
GLY A  69
SER A  90
MET A  93
SER A 135
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
 0.56A 3bxoB-5h02A:
22.9		 3bxoB-5h02A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 GLY A  69
SER A  90
MET A  93
ARG A 116
SER A 135
 SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.2A)
SAH  A 301 (-3.1A)
 0.63A 3bxoB-5h02A:
22.9		 3bxoB-5h02A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		6 / 12 ALA A  67
GLY A  69
GLY A  89
SER A  90
MET A  93
ASP A 114
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.7A)
 0.46A 3ou6A-5h02A:
17.4		 3ou6A-5h02A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 ALA A  67
GLY A  69
GLY A  89
SER A  90
MET A  93
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
 0.46A 3ou6B-5h02A:
17.0		 3ou6B-5h02A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 ALA A  67
GLY A  89
SER A  90
MET A  93
ASP A 114
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.7A)
 0.49A 3ou6C-5h02A:
17.1		 3ou6C-5h02A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 ALA A  67
GLY A  89
SER A  90
MET A  93
ASP A 114
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.7A)
 0.48A 3ou6D-5h02A:
16.8		 3ou6D-5h02A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		6 / 12 ALA A  67
GLY A  69
GLY A  89
SER A  90
MET A  93
ASP A 114
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.7A)
 0.43A 3ou7A-5h02A:
17.2		 3ou7A-5h02A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 ALA A  67
GLY A  69
GLY A  89
SER A  90
MET A  93
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
 0.48A 3ou7B-5h02A:
17.4		 3ou7B-5h02A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		3 / 3 GLY A  69
ASP A  88
ASP A 114
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.7A)
 0.23A 3ou7C-5h02A:
17.1		 3ou7C-5h02A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		6 / 12 ALA A  67
GLY A  69
GLY A  89
SER A  90
MET A  93
ASP A 114
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.7A)
 0.42A 3ou7D-5h02A:
16.9		 3ou7D-5h02A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 ALA A  67
GLY A  69
SER A  90
MET A  93
SER A 135
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
 0.46A 3pfgA-5h02A:
20.6		 3pfgA-5h02A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 GLY A  69
SER A  90
MET A  93
ASP A 114
SER A 135
 SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.1A)
 0.74A 3pfgA-5h02A:
20.6		 3pfgA-5h02A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 11 LEU A  55
GLY A  81
ALA A  80
ILE A  51
ILE A  52
 None
 0.97A 3s45B-5h02A:
undetectable		 3s45B-5h02A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		4 / 6 PHE A 152
LEU A 139
ALA A  67
LEU A 164
 None
None
SAH  A 301 (-3.9A)
None
 0.94A 3t3zA-5h02A:
undetectable		 3t3zA-5h02A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		4 / 6 PHE A 152
LEU A 139
ALA A  67
LEU A 164
 None
None
SAH  A 301 (-3.9A)
None
 0.97A 3t3zB-5h02A:
undetectable		 3t3zB-5h02A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		4 / 6 PHE A 152
LEU A 139
ALA A  67
LEU A 164
 None
None
SAH  A 301 (-3.9A)
None
 0.99A 3t3zD-5h02A:
undetectable		 3t3zD-5h02A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		6 / 12 GLY A  69
ASP A  88
MET A  93
ASP A 114
HIS A 138
LEU A 139
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.7A)
SAH  A 301 (-4.4A)
None
 0.97A 4iv8A-5h02A:
17.6		 4iv8A-5h02A:
29.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		6 / 12 GLY A  69
ASP A  88
MET A  93
ASP A 114
HIS A 138
LEU A 139
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.7A)
SAH  A 301 (-4.4A)
None
 0.97A 4iv8B-5h02A:
17.7		 4iv8B-5h02A:
29.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		4 / 4 ASP A  65
GLY A  69
ASP A  88
ASP A 114
 None
SAH  A 301 (-3.3A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.7A)
 0.71A 5e72A-5h02A:
18.1		 5e72A-5h02A:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		11 / 12 ALA A  67
GLY A  69
PHE A  72
GLY A  89
SER A  90
MET A  93
TRP A 115
ARG A 116
GLY A 133
SER A 135
LEU A 139
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.3A)
None
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.2A)
SAH  A 301 ( 3.3A)
SAH  A 301 (-3.1A)
None
 0.35A 5gwxA-5h02A:
41.5		 5gwxA-5h02A:
98.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		6 / 12 GLY A  89
SER A  90
MET A  93
TRP A 115
HIS A 138
LEU A 139
 SAH  A 301 (-3.4A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.4A)
None
 1.26A 5gwxA-5h02A:
41.5		 5gwxA-5h02A:
98.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		3 / 3 ARG A  43
ASN A  73
ASP A  88
 SAH  A 301 ( 3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-2.8A)
 0.10A 5gwxA-5h02A:
41.5		 5gwxA-5h02A:
98.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		11 / 12 ARG A  43
GLY A  69
ASN A  73
GLY A  89
SER A  90
MET A  93
ASP A 114
TRP A 115
ARG A 116
GLY A 133
SER A 135
 SAH  A 301 ( 3.2A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.2A)
SAH  A 301 ( 3.3A)
SAH  A 301 (-3.1A)
 0.22A 5hikA-5h02A:
41.6		 5hikA-5h02A:
98.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		5 / 12 GLY A  69
SER A  90
MET A  93
TRP A 115
HIS A 138
 SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.4A)
 1.18A 5hikA-5h02A:
41.6		 5hikA-5h02A:
98.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		4 / 4 SER A 135
THR A  70
ASP A  99
ASP A  65
 SAH  A 301 (-3.1A)
None
None
None
 1.30A 5vimA-5h02A:
7.5		 5vimA-5h02A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		4 / 4 SER A 135
THR A  70
ASP A  99
ASP A  65
 SAH  A 301 (-3.1A)
None
None
None
 1.29A 5vimB-5h02A:
8.0		 5vimB-5h02A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		4 / 5 THR A 240
LEU A 149
VAL A  66
LEU A 156
 None
 0.95A 6bqgA-5h02A:
undetectable		 6bqgA-5h02A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		4 / 5 HIS A 183
VAL A 192
PHE A 255
ARG A 167
 None
None
BET  A 303 (-4.6A)
BET  A 303 (-4.3A)
 1.40A 6hxiB-5h02A:
5.6		 6hxiB-5h02A:
18.61