SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5h04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		5 / 7 ARG A 297
SER A 340
PHE A 351
ARG A 354
GLU A 382
 NAI  A 501 (-2.8A)
NAI  A 501 (-2.6A)
NAI  A 501 (-4.0A)
NAI  A 501 (-3.0A)
NAI  A 501 (-3.1A)
 0.78A 2c8aA-5h04A:
20.3		 2c8aA-5h04A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		5 / 7 ARG A 297
SER A 340
PHE A 351
ARG A 354
GLU A 382
 NAI  A 501 (-2.8A)
NAI  A 501 (-2.6A)
NAI  A 501 (-4.0A)
NAI  A 501 (-3.0A)
NAI  A 501 (-3.1A)
 0.86A 2c8aB-5h04A:
20.0		 2c8aB-5h04A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		5 / 6 ARG A 297
SER A 340
PHE A 351
ARG A 354
GLU A 382
 NAI  A 501 (-2.8A)
NAI  A 501 (-2.6A)
NAI  A 501 (-4.0A)
NAI  A 501 (-3.0A)
NAI  A 501 (-3.1A)
 0.76A 2c8aC-5h04A:
19.8		 2c8aC-5h04A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		5 / 7 ARG A 297
SER A 340
PHE A 351
ARG A 354
GLU A 382
 NAI  A 501 (-2.8A)
NAI  A 501 (-2.6A)
NAI  A 501 (-4.0A)
NAI  A 501 (-3.0A)
NAI  A 501 (-3.1A)
 0.75A 2c8aD-5h04A:
20.3		 2c8aD-5h04A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		4 / 8 ILE A 280
SER A 281
ASP A 386
LEU A 384
 None
 1.00A 2cdqA-5h04A:
undetectable		 2cdqA-5h04A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		5 / 12 ILE A 116
ILE A 154
LYS A 203
LEU A 191
ILE A 121
 None
 1.10A 3cd2A-5h04A:
undetectable		 3cd2A-5h04A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		4 / 6 THR A  87
SER A 168
ASP A   4
THR A 162
 None
 1.05A 3q70A-5h04A:
undetectable		 3q70A-5h04A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		4 / 7 PHE A 103
ALA A 120
ILE A 193
LEU A 191
 None
 0.95A 4uymA-5h04A:
undetectable		 4uymA-5h04A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		4 / 7 TYR A 252
ARG A 297
SER A 340
GLU A 382
 NAI  A 501 (-3.4A)
NAI  A 501 (-2.8A)
NAI  A 501 (-2.6A)
NAI  A 501 (-3.1A)
 1.16A 4xzkA-5h04A:
15.3		 4xzkA-5h04A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		4 / 7 TYR A 252
SER A 340
PHE A 351
GLU A 382
 NAI  A 501 (-3.4A)
NAI  A 501 (-2.6A)
NAI  A 501 (-4.0A)
NAI  A 501 (-3.1A)
 1.32A 4xzkA-5h04A:
15.3		 4xzkA-5h04A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		4 / 5 SER A  84
ARG A 177
GLY A 170
ARG A  24
 None
 1.18A 5cdqR-5h04A:
undetectable
5cdqS-5h04A:
undetectable
5cdqT-5h04A:
undetectable		 5cdqR-5h04A:
20.96
5cdqS-5h04A:
20.46
5cdqT-5h04A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		3 / 3 ASN A 279
SER A 282
SER A 281
 None
 0.78A 5gsnA-5h04A:
undetectable		 5gsnA-5h04A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		4 / 5 LEU A 384
VAL A 371
GLU A 375
LEU A 248
 None
None
None
NAI  A 501 (-4.7A)
 1.07A 5xooB-5h04A:
undetectable		 5xooB-5h04A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		5 / 9 ASP A 112
ALA A 202
ILE A 116
GLY A 198
SER A 113
 None
 1.35A 6awoA-5h04A:
undetectable		 6awoA-5h04A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		5 / 9 ASP A 112
ALA A 202
ILE A 116
GLY A 198
SER A 113
 None
 1.35A 6awqA-5h04A:
undetectable		 6awqA-5h04A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		4 / 4 ILE A 154
LEU A 186
HIS A 157
ALA A 206
 None
 1.05A 6ck2C-5h04A:
undetectable
6ck2D-5h04A:
undetectable		 6ck2C-5h04A:
6.75
6ck2D-5h04A:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A
(Clostridium
perfringens) 		5 / 12 GLY A 183
GLN A 182
LEU A 158
ILE A 209
TYR A  43
 None
 1.30A 6md4A-5h04A:
undetectable		 6md4A-5h04A:
11.84